Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

scientific article published on January 1995

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-2952(94)00333-5
P698PubMed publication ID7530954

P2093author name stringCadenas E
P2860cites workPurified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitroQ28325359
Quinoneimines as substrates for quinone reductase (NAD(P)H: (quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicityQ28338141
DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation ratesQ28340699
Redox and addition chemistry of quinoid compounds and its biological implicationsQ34046274
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidationQ34207376
Toxicology of quinone-thioethersQ35662745
DT-diaphorase and cancer chemotherapyQ36066319
A note on the inhibition of DT-diaphorase by dicoumarolQ36692102
Molecular mechanisms of quinone cytotoxicityQ37367251
Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiationQ37617336
The role of Ca2+ in cell killingQ37804783
Bioreductive activation of quinones: redox properties and thiol reactivityQ37932453
Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinonesQ38036275
NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissuesQ38318799
Mechanistic toxicology: a radical perspectiveQ38365351
Metabolism and reactions of quinoid anticancer agentsQ39687822
Studies on the reaction mechanism of DT diaphorase. Intermediary plateau and trough regions in the initial velocity vs substrate concentration curvesQ39955470
Molecular biology of the carcinogen, 4-nitroquinoline 1-oxideQ40755366
DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.Q40848147
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomasQ41095155
Role of DT diaphorase the cytotoxicity of menadione and 4-nitroquinoline-1-oxide in cultured mammalian fibroblastic cellsQ41137916
The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cellsQ41177634
Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.Q41495379
Biochemical characterization of a mitomycin C resistant colon cancer cell line variantQ41509735
In vitro cytotoxicities of 1,4-naphthoquinone and hydroxylated 1,4-naphthoquinones to replicating cellsQ41532876
Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinoneQ41545941
Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. II. Enhancement of the alkylating activity of AZQ by NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase)Q41598357
The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)Q41620330
Thiol oxidation coupled to DT-diaphorase-catalysed reduction of diaziquone. Reductive and oxidative pathways of diaziquone semiquinone modulated by glutathione and superoxide dismutaseQ41820448
DT-diaphorase-catalyzed two-electron reduction of quinone epoxidesQ42208457
Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondriaQ42210897
Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity.Q42243536
One- and two-electron reduction of 2-methyl-1,4-naphthoquinone bioreductive alkylating agents: kinetic studies, free-radical production, thiol oxidation and DNA-strand-break formationQ42828327
Inhibition of mouse glutathione transferases and glutathione peroxidase II by dicumarol and other ligandsQ44132110
Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidationQ44305633
Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cellsQ44547419
NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicalsQ44549080
Mechanisms of toxicity of naphthoquinones to isolated hepatocytesQ44849526
Mechanisms of toxicity of 2- and 5-hydroxy-1,4-naphthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1,4-naphthoquinone to isolated hepatocytesQ44937533
Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity studyQ46087619
Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphoraseQ46150960
Effect of glutathione on the redox transitions of naphthohydroquinone derivatives formed during DT-diaphorase catalysisQ46958262
Possible role of DT-diaphorase in the bioactivation of antitumor quinonesQ50211954
Developmental toxicity of bromohydroquinone (BHQ) and BHQ-glutathione conjugates in vivo and in whole embryo culture.Q52225542
The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.Q52233976
Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase.Q52239229
Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: Reaction kinetics, and influence of oxygen and structure of thiyl radicalsQ52425935
One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents.Q52631238
CARCINOGENIC AROMATIC HYDROCARBONS: SPECIAL VULNERABILITY OF RATS.Q53612378
Quinone toxicity in hepatocytes without oxidative stress.Q54419485
Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.Q54423694
Induction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblastsQ58862368
Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytesQ58862376
DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxidesQ67254965
Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinonesQ67270918
Reduction of adrenochrome by rat liver and brain DT-diaphoraseQ67298039
Redox cycling of potential antitumor aziridinyl quinonesQ67507730
The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: possible role in cytotoxicityQ67525290
The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09Q67696876
Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinonesQ67967037
The enzymology of doxorubicin quinone reduction in tumour tissueQ67973838
The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?Q68025801
Bioreductive activation of mitomycin C by DT-diaphoraseQ68026086
Reactions of glutathione and glutathione radicals with benzoquinonesQ68134679
Reductive activation of mitomycin C: a delicate balanceQ68215848
Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma TumorsQ68215863
The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: free radical formation and NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase) activityQ68254280
Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive additionQ68255427
Rat liver DT-diaphorase as a nitroso-reductaseQ68346453
DT-diaphorase: purification, properties, and functionQ68592259
Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomesQ68980179
Study of the redox properties of naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its glutathionyl conjugate in biological reactions: one- and two-electron enzymatic reductionQ69258318
Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanismsQ69329235
On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutaseQ69362107
Potential bioreductive alkylating agents. 1. Benzoquinone derivativesQ69386558
Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytesQ69691684
Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytesQ69825811
Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acidsQ70140039
Peroxidase activation of 1-naphthol to naphthoxy or naphthoxy-derived radicals and their reaction with glutathioneQ70141991
Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: an ESR studyQ70164450
The reduction of anti-tumour diaziridinyl benzoquinonesQ70190719
Free radical formation from anthracycline antitumour agents and model systems--I. Model naphthoquinones and anthraquinonesQ70195642
A comparison of free radical formation by quinone antitumour agents in MCF-7 cells and the role of NAD(P)H (quinone-acceptor) oxidoreductase (DT-diaphorase)Q70488690
Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphoraseQ70631297
Does lung NAD(P)H:quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia?Q70631355
Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteinsQ71520102
Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutaseQ72907878
Induction of antioxidant enzymes and DT-diaphorase in human blood mononuclear cells by light stressQ72926356
DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formationQ72938975
The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductaseQ72941235
Superoxide as an intracellular radical sinkQ72958737
A thermodynamic appraisal of the radical sink hypothesisQ72958745
DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and propertiesQ79383164
Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditionsQ93532002
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)127-140
P577publication date1995-01-01
P1433published inBiochemical PharmacologyQ864229
P1476titleAntioxidant and prooxidant functions of DT-diaphorase in quinone metabolism
P478volume49

Reverse relations

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