review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0006-2952(94)00333-5 |
P698 | PubMed publication ID | 7530954 |
P2093 | author name string | Cadenas E | |
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The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells | Q41177634 | ||
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Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells | Q44547419 | ||
NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals | Q44549080 | ||
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Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study | Q46087619 | ||
Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase | Q46150960 | ||
Effect of glutathione on the redox transitions of naphthohydroquinone derivatives formed during DT-diaphorase catalysis | Q46958262 | ||
Possible role of DT-diaphorase in the bioactivation of antitumor quinones | Q50211954 | ||
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The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins. | Q52233976 | ||
Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase. | Q52239229 | ||
Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: Reaction kinetics, and influence of oxygen and structure of thiyl radicals | Q52425935 | ||
One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents. | Q52631238 | ||
CARCINOGENIC AROMATIC HYDROCARBONS: SPECIAL VULNERABILITY OF RATS. | Q53612378 | ||
Quinone toxicity in hepatocytes without oxidative stress. | Q54419485 | ||
Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes. | Q54423694 | ||
Induction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblasts | Q58862368 | ||
Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes | Q58862376 | ||
DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides | Q67254965 | ||
Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinones | Q67270918 | ||
Reduction of adrenochrome by rat liver and brain DT-diaphorase | Q67298039 | ||
Redox cycling of potential antitumor aziridinyl quinones | Q67507730 | ||
The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: possible role in cytotoxicity | Q67525290 | ||
The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09 | Q67696876 | ||
Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinones | Q67967037 | ||
The enzymology of doxorubicin quinone reduction in tumour tissue | Q67973838 | ||
The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase? | Q68025801 | ||
Bioreductive activation of mitomycin C by DT-diaphorase | Q68026086 | ||
Reactions of glutathione and glutathione radicals with benzoquinones | Q68134679 | ||
Reductive activation of mitomycin C: a delicate balance | Q68215848 | ||
Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors | Q68215863 | ||
The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: free radical formation and NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase) activity | Q68254280 | ||
Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive addition | Q68255427 | ||
Rat liver DT-diaphorase as a nitroso-reductase | Q68346453 | ||
DT-diaphorase: purification, properties, and function | Q68592259 | ||
Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes | Q68980179 | ||
Study of the redox properties of naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its glutathionyl conjugate in biological reactions: one- and two-electron enzymatic reduction | Q69258318 | ||
Auto-oxidation of dialuric acid, divicine and isouramil. Superoxide dependent and independent mechanisms | Q69329235 | ||
On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase | Q69362107 | ||
Potential bioreductive alkylating agents. 1. Benzoquinone derivatives | Q69386558 | ||
Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes | Q69691684 | ||
Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes | Q69825811 | ||
Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids | Q70140039 | ||
Peroxidase activation of 1-naphthol to naphthoxy or naphthoxy-derived radicals and their reaction with glutathione | Q70141991 | ||
Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: an ESR study | Q70164450 | ||
The reduction of anti-tumour diaziridinyl benzoquinones | Q70190719 | ||
Free radical formation from anthracycline antitumour agents and model systems--I. Model naphthoquinones and anthraquinones | Q70195642 | ||
A comparison of free radical formation by quinone antitumour agents in MCF-7 cells and the role of NAD(P)H (quinone-acceptor) oxidoreductase (DT-diaphorase) | Q70488690 | ||
Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase | Q70631297 | ||
Does lung NAD(P)H:quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia? | Q70631355 | ||
Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins | Q71520102 | ||
Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase | Q72907878 | ||
Induction of antioxidant enzymes and DT-diaphorase in human blood mononuclear cells by light stress | Q72926356 | ||
DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation | Q72938975 | ||
The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase | Q72941235 | ||
Superoxide as an intracellular radical sink | Q72958737 | ||
A thermodynamic appraisal of the radical sink hypothesis | Q72958745 | ||
DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties | Q79383164 | ||
Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions | Q93532002 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 127-140 | |
P577 | publication date | 1995-01-01 | |
P1433 | published in | Biochemical Pharmacology | Q864229 |
P1476 | title | Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism | |
P478 | volume | 49 |
Q38251996 | 1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling |
Q40632205 | 3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro. |
Q44096853 | A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells |
Q44133736 | A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile |
Q35718488 | Activation and detoxification of naphthoquinones by NAD(P)H: quinone oxidoreductase |
Q28481620 | An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer |
Q50134130 | Aromatic Hydrocarbon Quinone-mediated Reactive Oxygen Species Production in Hepatic Microsomes of the Flounder (Platichthys flesus L.) |
Q37483161 | Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells |
Q73024325 | Autoxidation of naphthohydroquinones: effects of metals, chelating agents, and superoxide dismutase |
Q34447919 | Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice |
Q41145264 | Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase |
Q37163327 | CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy |
Q37364065 | Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells |
Q40902202 | Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents. |
Q36372007 | Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli. |
Q36956417 | Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia |
Q28375775 | Coenzyme Q10 does not prevent oral dyskinesias induced by long-term haloperidol treatment of rats |
Q71869415 | DT-Diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function |
Q54067376 | DT-diaphorase protects against menadione-induced oxidative stress. |
Q35718389 | Diaziridinylbenzoquinones |
Q35108781 | Differential responses of targeted lung redox enzymes to rat exposure to 60 or 85% oxygen |
Q34904211 | Disruption of Pyridine Nucleotide Redox Status During Oxidative Challenge at Normal and Low-Glucose States: Implications for Cellular Adenosine Triphosphate, Mitochondrial Respiratory Activity, and Reducing Capacity in Colon Epithelial Cells |
Q37405043 | Do β-cells generate peroxynitrite in response to cytokine treatment? |
Q59812763 | Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction |
Q64789910 | Drug treatment of Parkinson's disease. Time for phase II |
Q36603159 | EO9 (Apaziquone): from the clinic to the laboratory and back again |
Q77221128 | Effect of butylated hydroxyanisole on the toxicity of 2-hydroxy-1,4-naphthoquinone to rats |
Q46580584 | Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs |
Q73401122 | Effect of inducers of DT-diaphorase on the toxicity of 2-methyl- and 2-hydroxy-1,4-naphthoquinone to rats |
Q39793054 | Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. |
Q43729048 | Effects of beta-naphthoflavone on the cytochrome P450 system, and phase II enzymes in gilthead seabream (Sparus aurata). |
Q74404137 | Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats |
Q43541968 | Effects of modulation of tissue activities of DT-diaphorase on the toxicity of 2,3-dimethyl-1,4-naphthoquinone to rats |
Q24811292 | Effects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss) |
Q73897732 | Enzymatic biomarker measurement and study of DNA adduct formation in benzo |
Q41078518 | Enzymology of bioreductive drug activation |
Q60360742 | Evidence for cytochrome P-450 catalysis and free radical involvement in the production of DNA strand breaks by benzo[a]pyrene and nitroaromatics in mussel (Mytilus edulis L.) digestive gland cells |
Q43744817 | Expression of NAD(P)H:quinone oxidoreductase 1 in HeLa cells: role of hydrogen peroxide and growth phase |
Q45980930 | Extracellular activation of fluorinated aziridinylbenzoquinone in HT29 cells EPR studies. |
Q41539407 | Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch |
Q36249238 | Genetic susceptibility to iatrogenic malignancy |
Q37293046 | Glutathione maintenance mitigates age-related susceptibility to redox cycling agents |
Q35440426 | High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma |
Q40794878 | High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes |
Q28368374 | Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis |
Q39985659 | Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways |
Q73682427 | Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer |
Q22306224 | In Vitro and in Vivo Regulation of Antioxidant Response Element-Dependent Gene Expression by Estrogens |
Q39976476 | In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs. |
Q44583482 | Induction of chromosomal aberrations by phenolic compounds: possible role of reactive oxygen species. |
Q42552201 | Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells |
Q48179094 | Inflammation, oxidative stress, and higher expression levels of Nrf2 and NQO1 proteins in the airways of women chronically exposed to biomass fuel smoke |
Q45232857 | Influence of plasma total antioxidant ability on lipid and protein oxidation products in plasma and erythrocyte ghost obtained from developing and adult rats pretreated with two vitamin K formulations |
Q46769489 | Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1. |
Q77988232 | Inhibition of 2,3-dimethyl-1,4-naphthohydroquinone auto-oxidation by copper and by superoxide dismutase |
Q40184984 | Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. |
Q41992288 | Integrated assessment of water quality of the Costa da Morte (Galicia, NW Spain) by means of mussel chemical, biochemical and physiological parameters. |
Q35089285 | Interactive effect of smoking and NQO1 haplotypes on lung cancer risk |
Q46514057 | Involvement of oxygen free radicals in the serum-mediated increase of benzoquinone genotoxicity. |
Q53845593 | L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. |
Q41820608 | Markers of oxidative stress in senescent erythrocytes obtained from young and old age rats |
Q52845977 | Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. |
Q28372188 | Modulation of halobenzene-induced hepatotoxicity by DT-diaphorase modulators, butylated hydroxyanisole and dicoumarol: evidence for possible involvement of quinone metabolites in the toxicity of halobenzenes |
Q37241608 | NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans |
Q36178176 | NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia |
Q46857642 | NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis |
Q40899393 | NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity |
Q28142533 | NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms |
Q35718416 | NAD(P)H:quinone oxidoreductase 1 expression, hydrogen peroxide levels, and growth phase in HeLa cells |
Q53236815 | NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease. |
Q40186008 | NQO1 C609T Polymorphism is Associated with Coronary Artery Disease in a Gender-Dependent Manner |
Q38341596 | NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps |
Q38603364 | Nanotechnology-enabled delivery of NQO1 bioactivatable drugs |
Q46648220 | Naphthoquinone-dependent generation of superoxide radicals by quinone reductase isolated from the plasma membrane of soybean. |
Q40863938 | Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation |
Q34481778 | Neuroprotection for Parkinson's disease: a new approach for a new millennium |
Q37133497 | Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells |
Q45238381 | No role of DT-diaphorase (NQO1) in the protection against oxidized quercetin |
Q74107115 | One-electron reduction of quinones by the neuronal nitric-oxide synthase reductase domain |
Q44230771 | Paraquat and menadione exposure of rainbow trout (Oncorhynchus mykiss)--studies of effects on the pentose-phosphate shunt and thiamine levels in liver and kidney |
Q34062692 | Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen |
Q35772582 | Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia |
Q37600687 | Phase I and pharmacokinetic study of mitomycin C and celecoxib as potential modulators of tumor resistance to irinotecan in patients with solid malignancies |
Q44097248 | Polymorphism of metabolic genes and susceptibility to occupational chronic manganism |
Q24805337 | Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and beta-lapachone combination treatment |
Q37089301 | Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells |
Q38132402 | Proteomic insights into seed germination in response to environmental factors |
Q44374156 | Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. |
Q77799982 | Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product |
Q35707967 | Quinone oxidoreductases of the plasma membrane |
Q40977859 | Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines |
Q35708041 | Quinones and glutathione metabolism. |
Q35707903 | Redox cycling of beta-lapachone and structural analogues in microsomal and cytosol liver preparations |
Q44017870 | Reductive activation of terpenylnaphthoquinones |
Q35880464 | Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1. |
Q32141179 | Relationships between tissue concentrations of polycyclic aromatic hydrocarbons and antioxidative responses of marine mussels, Perna viridis |
Q43839978 | Role of membrane charge and semiquinone structure on naphthosemiquinone derivatives and 1,4-benzosemiquinone disproportionation and membrane-buffer distribution coefficients |
Q50965811 | Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia. |
Q74159716 | Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity |
Q43791018 | Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH. |
Q38887555 | Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1. |
Q43456515 | The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma |
Q92462353 | The diverse mechanisms and anticancer potential of naphthoquinones |
Q78115619 | The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes |
Q62066175 | The pro-oxidant role of protein SH groups of hemoglobin in rat erythrocytes exposed to menadione |
Q37697007 | The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems |
Q34062707 | The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review |
Q37729858 | The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice |
Q44505545 | The role of quinone reductase (NQO1) and quinone chemistry in quercetin cytotoxicity |
Q73614252 | The two-electron quinone reductase DT-diaphorase generates and maintains the antioxidant (reduced) form of coenzyme Q in membranes |
Q41788147 | WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases. |
Q104495309 | Zone-specific damage of the olfactory epithelium under protein restriction |
Q51023901 | β-phenethylamine--a phenylalanine derivative in brain--contributes to oxidative stress by inhibiting mitochondrial complexes and DT-diaphorase: an in silico study. |
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