Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling.

scientific article published on 20 December 2016

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JP273269
P932PMC publication ID5330876
P698PubMed publication ID28000223

P50authorKaran UppalQ56808353
Andrew T GewirtzQ100427123
P2093author name stringGe Li
Behtash Ghazi Nezami
Shanthi Srinivasan
Matam Vijay-Kumar
Benoit Chassaing
François Reichardt
Simon Mwangi
Dean Jones
Bill Liang
Sahar Tabatabavakili
P2860cites workThe gut microbiota as an environmental factor that regulates fat storageQ28131676
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndromeQ28382948
Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinaseQ28542433
In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytesQ28570362
MetabNet: An R Package for Metabolic Association Analysis of High-Resolution Metabolomics Data.Q30977629
Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjectsQ33598384
Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stressQ33715744
AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota compositionQ33872260
GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathwayQ34331361
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammationQ34408108
High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathwayQ34455345
Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agentsQ34591044
Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in miceQ34619950
Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous systemQ34789106
Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese miceQ34934180
Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in miceQ35047606
Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitroQ35061242
Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent.Q35572939
Association of high dietary saturated fat intake and uncontrolled diabetes with constipation: evidence from the National Health and Nutrition Examination SurveyQ36096067
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signalingQ36279376
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophagesQ36579422
Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural functionQ37034295
Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed miceQ37095241
Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver DiseaseQ37297361
Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root gangliaQ37389400
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent mannerQ37448034
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized miceQ37472976
Effect of high fat-diet and obesity on gastrointestinal motilityQ37473305
Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot studyQ37561412
Neuroinflammation in inflammatory bowel diseaseQ37771058
The involvement of nitric oxide synthase neurons in enteric neuropathies.Q37927166
High-fat diet promotes neuronal loss in the myenteric plexus of the large intestine in mice.Q38303452
High-fat diet ingestion correlates with neuropathy in the duodenum myenteric plexus of obese mice with symptoms of type 2 diabetesQ38457192
Effects of LPS and dietary free fatty acids on MCP-1 in 3T3-L1 adipocytes and macrophages in vitroQ38600016
MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in miceQ39026058
Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factorQ39436138
Prolonged high fat diet ingestion, obesity, and type 2 diabetes symptoms correlate with phenotypic plasticity in myenteric neurons and nerve damage in the mouse duodenumQ41905246
Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary culturesQ42119593
Formulation of the Total Western Diet (TWD) as a basal diet for rodent cancer studies.Q42500109
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.Q42931889
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse modelQ42956933
Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity.Q43263070
The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.Q44468994
Lipopolysaccharide induces cell death in cultured porcine myenteric neurons.Q46679821
Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet.Q50468098
Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut.Q52230310
Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice.Q53636124
Folate Derived from Cecal Bacterial Fermentation Does Not Increase Liver Folate Stores in 28-d Folate-Depleted Male Sprague-Dawley RatsQ57101543
Intestinal formation of hypoxanthine and uric acid during endotoxemiaQ73626602
Regional differences in the nitrergic innervation between the proximal and the distal colon in ratsQ77620725
Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthaseQ79629300
Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humansQ80151097
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
lipopolysaccharideQ421804
fatty acidQ61476
P304page(s)1831-1846
P577publication date2017-02-08
P1433published inJournal of PhysiologyQ7743612
P1476titleWestern diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling
P478volume595