An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter

scientific article published on August 1994

An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/22.15.3053
P932PMC publication ID310275
P698PubMed publication ID8065919
P5875ResearchGate publication ID15133167

P50authorMattias MannervikQ38549090
Camilla I SvenssonQ59689137
P2093author name stringAkusjärvi G
Bondesson M
P2860cites workPurification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition methodQ24631695
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activationQ28303864
The E2F transcription factor is a cellular target for the RB proteinQ29620422
Transcription activation by the adenovirus E1a proteinQ29620538
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene productsQ33630332
Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free systemQ33860609
A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation propertiesQ33929351
Expression of a β-globin gene is enhanced by remote SV40 DNA sequencesQ34055192
Cellular targets for transformation by the adenovirus E1A proteinsQ34438094
Adenovirus E1A targets key regulators of cell proliferationQ35260997
DNA-binding properties of an adenovirus 289R E1A proteinQ35979340
Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthQ36640038
Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1aQ36659815
A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoproteinQ36676343
Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainsQ36702851
Diverse transcriptional functions of the multisubunit eukaryotic TFIID complexQ36738427
Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene productsQ36762817
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activityQ36783092
Two regions of the adenovirus early region 1A proteins are required for transformation.Q36826321
Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control regionQ36889637
E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNAQ36894597
E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely relatedQ36897529
Adenovirus E1a proteins repress expression from polyomavirus early and late promotersQ36899992
Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A productsQ36904036
The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assemblyQ36924748
Expression and interactions of human adenovirus oncoproteinsQ37083966
Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IIDQ37531197
Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formationQ37583264
Adenovirus E1A protein paradigm viral transactivatorQ38261759
A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a proteinQ38340347
Repression of RNA polymerase III transcription by adenovirus E1A.Q40046033
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donorQ40170620
Proteins with transcription regulatory properties encoded by human adenovirusesQ40733100
Enhancer activation by a single type of transcription factor shows cell type dependenceQ41082106
Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformationQ41345257
Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promotersQ41357555
The carboxy-terminal exon of the adenovirus E1A protein is required for E4F-dependent transcription activationQ41535980
Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.Q41567198
Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein.Q41576846
Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5Q41627627
A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cellsQ41673905
Independent transformation activity by adenovirus-5 E1A-conserved regions 1 or 2 mutants.Q41682125
A novel function of the transforming domain of E1a: repression of AP-1 activityQ41725174
Splicing of adenovirus 2 early region 1A mRNAs is non-sequentialQ43795997
Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factorsQ43959514
Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exonQ44132091
An adenovirus E1a protein region required for transformation and transcriptional repressionQ44198736
Adenovirus E1a proteins repress transcription from the SV40 early promoterQ44991664
Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene productQ45838465
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factorQ46050449
Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomasQ46228936
Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factorQ52480364
Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma.Q52833927
Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen.Q53514604
Functional domains of adenovirus type 5 E1a proteins.Q53527275
Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products.Q53540752
Structure of two spliced mRNAs from the transforming region of human subgroup C adenovirusesQ53580928
Functional interaction of adenovirus E1A with holo-TFIIDQ64377679
Regulation of the human hsp70 promoter by p53Q64377885
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cellsQ64378165
A novel effect of adenovirus VA RNA1 on cytoplasmic mRNA abundanceQ64378813
General repression of enhanson activity by the adenovirus-2 E1A proteinsQ64378862
Repression of cytochrome P-450c gene expression by cotransfection with adenovirus E1a DNAQ64379163
Response of individual adenovirus promoters to the products of the E1A geneQ64379953
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcriptionQ64380517
P433issue15
P921main subjectAdenoviridaeQ193447
P304page(s)3053-3060
P577publication date1994-08-01
P1433published inNucleic Acids ResearchQ135122
P1476titleAn adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter
P478volume22

Reverse relations

cites work (P2860)
Q38352779A novel E1A domain mediates skeletal-muscle-specific enhancer repression independently of pRB and p300 binding
Q32061549AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.
Q39874705Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter
Q42280948Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation
Q33902989Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.
Q41232401Comparison of E1A CR3-Dependent Transcriptional Activation across Six Different Human Adenovirus Subgroups
Q40471506Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.
Q40894288E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products.
Q34381615E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.
Q52594256Identification of a second independent binding site for the pCAF acetyltransferase in adenovirus E1A.
Q40179630Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators
Q37127084Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.
Q47549172Mimicry of cellular A kinase anchoring proteins is a conserved and critical function of E1A across various human adenovirus species
Q40275053Requirement of Sur2 for efficient replication of mouse adenovirus type 1.
Q33431467Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae
Q42676601Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.
Q34601820The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation
Q40393050The DNA binding domains of the yeast Gal4 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs
Q64378744The adenovirus E1A protein targets the SAGA but not the ADA transcriptional regulatory complex through multiple independent domains
Q38359241The adenovirus e3 promoter is sensitive to activation signals in human T cells
Q28275328The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
Q36883871The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction
Q39897926Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.
Q34778486Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation

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