DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.

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DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.115.306541
P932PMC publication ID4662626
P698PubMed publication ID26471266

P2093author name stringThomas Gridley
Lucy Liaw
Bahman Rostama
Calvin P H Vary
Christine R Norton
Jacqueline E Turner
Guy T Seavey
P2860cites workBMP9 and BMP10 are critical for postnatal retinal vascular remodeling.Q36057921
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disordersQ36079508
Enhanced gene activation by Notch and BMP signaling cross-talkQ36119543
Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).Q36140753
BMP9 regulates endoglin-dependent chemokine responses in endothelial cellsQ36410172
The role of extracellular matrix in vascular branching morphogenesisQ36542074
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.Q36750033
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development.Q37031726
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescenceQ37080802
Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cellsQ37151702
Therapeutic promise and challenges of targeting DLL4/NOTCH1.Q38367121
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motifQ38855307
Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signalingQ39017680
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.Q39320608
Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion.Q40256534
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.Q40620265
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stabilityQ40876935
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesisQ42010099
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascadesQ42098324
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor levelQ42560909
Endothelial cells dynamically compete for the tip cell position during angiogenic sproutingQ42876374
Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliterationQ44675917
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisQ45345843
Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1.Q50596384
Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells.Q50719379
Chronic DLL4 blockade induces vascular neoplasmsQ59082154
Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial CellsQ61894113
Bone morphogenetic protein-9 is a circulating vascular quiescence factorQ24657942
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3Q24672178
Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformationsQ27302123
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancerQ28203143
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsQ28505269
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressorsQ28505707
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signallingQ28587298
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalizationQ28589223
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesisQ29614939
Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compoundsQ30493655
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Q33719706
Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathwayQ33784355
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia modelsQ33818037
Molecular pathways: can activin-like kinase pathway inhibition enhance the limited efficacy of VEGF inhibitors?Q33957962
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growthQ34096297
Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesisQ34141670
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localizationQ34150579
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell functionQ34458950
Delta-like 4 induces notch signaling in macrophages: implications for inflammationQ34632202
Thrombospondins 1 and 2 function as inhibitors of angiogenesisQ35114389
Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expressionQ35181476
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cellsQ35584425
Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis modelQ35651465
Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.Q35842264
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.Q35902676
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.Q36018663
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)2626-2637
P577publication date2015-10-15
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleDLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.
P478volume35

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cites work (P2860)
Q47856805ALK1 signaling in development and disease: new paradigms.
Q28066886Activin receptor-like kinases: a diverse family playing an important role in cancer
Q47127514Association of breast carcinoma growth with a non-canonical axis of IFNγ/IDO1/TSP1.
Q98171203BMP9 attenuates occurrence of venous malformation by maintaining endothelial quiescence and strengthening vessel walls via SMAD1/5/ID1/α-SMA pathway
Q89637587BMP9 signaling promotes the normalization of tumor blood vessels
Q60932686Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation
Q38937592Delta-Like Ligand 4-Notch Signaling in Macrophage Activation
Q92732372Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium
Q92940369Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells
Q48647117FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
Q35991193Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease
Q30362847Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice.
Q41108569Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves
Q58077846MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: Implications for BPD
Q52353052NOTCH regulation of the endothelial cell phenotype.
Q91761126NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy
Q88938326Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation
Q52890704Self-Renewal and High Proliferative Colony Forming Capacity of Late-Outgrowth Endothelial Progenitors Is Regulated by Cyclin-Dependent Kinase Inhibitors Driven by Notch Signaling.
Q58750618The Warburg Effect in Endothelial Cells and its Potential as an Anti-angiogenic Target in Cancer
Q91003142Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease
Q39403862Tumor angiogenesis and vascular normalization: alternative therapeutic targets
Q39393740Tumor angiogenesis revisited: Regulators and clinical implications.

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