Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary

scientific article published on February 1, 1995

Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/0197-0186(94)00104-3
P8608Fatcat IDrelease_sot6loyimjg2xaol3wz3oejbti
P953full work available at URLhttps://api.elsevier.com/content/article/PII:0197018694001043?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:0197018694001043?httpAccept=text/xml
P698PubMed publication ID7599530

P2093author name stringD. B. Campbell
P2860cites workMetabolism of fenfluramine to norfenfluramine in guinea-pigsQ34040026
What is an appropriate measure of exposure when testing drugs for carcinogenicity in rodents?Q35897498
Man versus beast: pharmacokinetic scaling in mammalsQ38705508
Comparison of the time course of the anorectic effect of fenfluramine and amphetamine with drug levels in bloodQ40327245
The current status of attempts to predict species differences in drug metabolismQ40327829
Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramineQ41197417
Fluoxetine and norfluoxetine are potent inhibitors of P450IID6--the source of the sparteine/debrisoquine oxidation polymorphismQ43205021
Fluoxetine and trifluoperazine in human brain: a 19F-nuclear magnetic resonance spectroscopy studyQ43597505
Quantification and mechanism of the fluoxetine and tricyclic antidepressant interactionQ43758388
Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigsQ43864916
Pharmacokinetics and brain entry of alaptide, a novel nootropic agent, in mice, rats and rabbitsQ44256898
Saturable transport of amphetamine across the blood-brain barrierQ44410782
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamineQ45025381
In-vivo (+)-[3H]fenfluramine binding to rat brain: biochemical and autoradiographic studiesQ45478577
A Comparative Study of the Pharmacokinetics of AmphetamineQ47899189
Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administrationQ48414122
The effect of previous d-amphetamine treatment on the disposition and lethality of fenfluramine in the rat.Q48478308
Nonlinear Tissue Disposition: Salicylic Acid in Rat BrainQ48487871
Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brainQ48500625
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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.Q52722509
Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphismQ60678421
Comparative biodisposition and metabolism of 14C-(+/-)-fenfluramine in mouse, rat, dog and manQ68000848
In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detectorQ69933538
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Regulatory history and experimental support of uncertainty (safety) factorsQ70295952
Kinetics of fenfluramine isomers in the ratQ71083316
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)103-110
P577publication date1995-02-01
P1433published inNeurochemistry InternationalQ7002160
P1476titleAre interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary
P478volume26

Reverse relations

cites work (P2860)
Q345657123,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
Q40945435The use of toxicokinetics for the safety assessment of drugs acting in the brain

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