Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the sirt1-p53-bax pathway

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Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the sirt1-p53-bax pathway is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1012107410
P356DOI10.1007/S11262-015-1253-2
P698PubMed publication ID26459383

P2093author name stringQi Wang
Min Li
Jun Cheng
Jinqian Zhang
Shunai Liu
Shenghu Feng
Mengran Zhang
Min Quan
P2860cites workHepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB.Q43418500
Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core proteinQ45758348
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.Q53171301
HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt.Q53260500
Negative control of p53 by Sir2alpha promotes cell survival under stressQ24291828
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseQ24310456
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damageQ24329260
Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor expression via activation of nuclear factor- BQ27478331
Hepatitis C virus core proteins derived from different quasispecies of genotype 1b inhibit the growth of Chang liver cellsQ27488899
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
Course and outcome of hepatitis CQ29620057
Overview of hepatitis C virus genome structure, polyprotein processing, and protein propertiesQ29620619
Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathwaysQ33355396
How does SIRT1 affect metabolism, senescence and cancer?Q33802917
SIRT1 and p53, effect on cancer, senescence and beyondQ34341091
Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytesQ34546501
Retracted: Hepatitis C Virus Core Protein Down-Regulates p21Waf1/Cip1 and Inhibits Curcumin-Induced Apoptosis through MicroRNA-345 Targeting in Human Hepatoma CellsQ34664107
Down-regulation of PTEN by HCV core protein through activating nuclear factor-κB.Q34733201
P53 and radiation responsesQ35208809
Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1Q37056760
SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathwayQ37179916
The ups and downs of SIRT1.Q37274584
Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC.Q37977788
Update on epidemiology of hepatitis B and C in ChinaQ38121565
Expression and role of SIRT1 in hepatocellular carcinomaQ38474269
SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell linesQ39301696
Hepatitis C virus core protein induces apoptosis-like caspase independent cell death.Q39403323
Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell lineQ39438822
Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core proteinQ39530828
Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activationQ39594009
Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosisQ39876832
Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cellsQ41090240
Suppression of apoptotic cell death by hepatitis C virus core proteinQ41145136
HCV core protein-induced down-regulation of microRNA-152 promoted aberrant proliferation by regulating Wnt1 in HepG2 cellsQ41862856
Evasion of TNF-α-mediated apoptosis by hepatitis C virusQ42221050
Suppression of serum starvation-induced apoptosis by hepatitis C virus core protein.Q42824678
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.Q42982113
Sensitization to Fas-mediated apoptosis by hepatitis C virus core proteinQ42982436
Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell deathQ42992419
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectHepatitis C virusQ708693
P304page(s)338-346
P577publication date2015-10-12
P1433published inVirus GenesQ15749213
P1476titleRegulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the sirt1-p53-bax pathway
P478volume51

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cites work (P2860)
Q51737218Autophagy, apoptosis, vitamin D, and vitamin D receptor in hepatocellular carcinoma associated with hepatitis C virus.
Q38774266Mechanism of Hepatocyte Apoptosis
Q45325177Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.
Q56972496Roles of p53 in extrinsic factor-induced liver carcinogenesis
Q40045469Sirt1 mediate HCV core protein induces hepatic steatosis
Q89509637The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction

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