Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

scientific article published on March 2005

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1020124707
P356DOI10.1038/SJ.ONC.1208421
P698PubMed publication ID15688014
P5875ResearchGate publication ID8044557

P50authorRené H. MedemaQ30788066
Silvia Fernández de MattosQ55130331
Eric W-F LamQ55686122
Inês SoeiroQ79285951
P2093author name stringGhulam J Mufti
Abdelkader Essafi
N Shaun B Thomas
Yasmin A M Hassen
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Signalling through phosphoinositide 3-kinases: the lipids take centre stageQ28141934
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1Q28142184
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell linesQ28207468
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressorQ28214576
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2Q28216784
Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylationQ28576927
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cellsQ29547557
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).Q33606105
The biology of chronic myeloid leukemiaQ33686190
The Akt pathway: molecular targets for anti-cancer drug developmentQ34319621
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off dutyQ35139549
Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factorQ35143436
FOXO transcription factors as regulators of immune homeostasis: molecules to die for?Q35193785
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrityQ36324207
The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activityQ36368162
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitorsQ40540288
Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnoverQ40606380
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Q40626751
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cellsQ40686902
BCR-ABL and interleukin 3 promote haematopoietic cell proliferation and survival through modulation of cyclin D2 and p27Kip1 expression.Q40809849
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.Q41740883
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosisQ41748320
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neuronsQ42918105
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteinsQ44775125
P230 BCR/ABL protein may be associated with an acute leukaemia phenotypeQ58459580
A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemiaQ59060532
BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cellsQ59102114
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)2317-2329
P577publication date2005-03-01
P1433published inOncogeneQ1568657
P1476titleDirect transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
P478volume24