Brincidofovir Is Not A Substrate For The Human Organic Anion Transporter 1 (Oat1): A Mechanistic Explanation For The Lack Of Nephrotoxicity Observed In Clinical Studies.

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Brincidofovir Is Not A Substrate For The Human Organic Anion Transporter 1 (Oat1): A Mechanistic Explanation For The Lack Of Nephrotoxicity Observed In Clinical Studies. is …
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scholarly articleQ13442814

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P698PubMed publication ID27851688

P2093author name stringTimothy K Tippin
Thomas M Brundage
Hervé Momméja-Marin
Marion E Morrison
P2860cites workTowards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulationsQ27020967
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Organic anion transporter (Slc22a) family members as mediators of toxicityQ36104160
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Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.Q39918902
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).Q40156820
The efficacy and pharmacokinetics of brincidofovir for the treatment of lethal rabbitpox virus infection: a model of smallpox diseaseQ41446122
CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantationQ42246598
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogsQ43741891
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox modelQ44769720
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.Q44970891
Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.Q46448267
Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drugQ71561685
Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbitsQ71565797
P577publication date2016-11-16
P1433published inTherapeutic Drug MonitoringQ15724567
P1476titleBrincidofovir Is Not A Substrate For The Human Organic Anion Transporter 1 (Oat1): A Mechanistic Explanation For The Lack Of Nephrotoxicity Observed In Clinical Studies.

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cites work (P2860)
Q90062923Advances in the Development of Therapeutics for Cytomegalovirus Infections
Q58609293Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via Both Non-Obligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus

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