Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.

scientific article

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M414420200
P698PubMed publication ID15640147

P50authorJennifer StowQ18166733
David A HumeQ49872722
Rachael Z MurrayQ51749222
Tatiana KhromykhQ57341784
P2093author name stringFiona G Wylie
P2860cites workSyntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophagesQ22254581
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.Q24292734
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificityQ24534126
EpsinR is an adaptor for the SNARE protein Vti1bQ24559947
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and functionQ24595623
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREsQ24656954
Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transportQ27933170
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cellsQ28119154
Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesiclesQ28140924
Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cellsQ28208262
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusionQ28255534
Phagosomes are competent organelles for antigen cross-presentationQ28591811
Membrane fusionQ29618140
Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosisQ31038598
In vivo analysis of growth hormone receptor signaling domains and their associated transcriptsQ33551712
Anti-TNF-alpha therapies: the next generationQ34227176
Syntaxin 6: the promiscuous behaviour of a SNARE protein.Q34368514
Post-transcriptional regulation of proinflammatory proteins.Q35742366
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion.Q40675160
Endocytosis of uncleaved tumor necrosis factor-alpha in macrophagesQ40825187
Syntaxin 11 is an atypical SNARE abundant in the immune systemQ40834596
Localization and post-Golgi trafficking of tumor necrosis factor-alpha in macrophagesQ40880774
Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharideQ41066063
Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytesQ42464766
Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formationQ42919576
Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophagesQ45345587
Lasker Basic Medical Research Award. The machinery and principles of vesicle transport in the cellQ48361351
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
exocytosisQ323426
P304page(s)10478-10483
P577publication date2005-01-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleSyntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.
P478volume280

Reverse relations

cites work (P2860)
Q27649128A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles
Q27326701A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?
Q42119244A role for syntaxin 3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors
Q36491396A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo
Q38700764Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants.
Q38421156An Emerging Role for SNARE Proteins in Dendritic Cell Function.
Q33816770An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
Q37015047Characterization of SNAREs determines the absence of a typical Golgi apparatus in the ancient eukaryote Giardia lamblia
Q34406845Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking
Q46972979Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup.
Q40661957Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages
Q40163297Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension.
Q34617225Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells
Q34619584Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis
Q33693183Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages
Q24539130GPX-Macrophage Expression Atlas: a database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults
Q37462198Genome-wide profiling of in vivo LPS-responsive genes in splenic myeloid cells
Q36386541Human NK cell lytic granules and regulation of their exocytosis
Q24313394Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery
Q63988407Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Q38002003Immune regulation of Rab proteins expression and intracellular transport.
Q42202859Innate immunity and exocytosis of antimicrobial peptides
Q24300258Intracellular location of syntaxin 7 in human neutrophils
Q93198245Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis
Q39624592Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively
Q53129928Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes.
Q34299710Macrophage cytokines: involvement in immunity and infectious diseases
Q48203071N-linked glycosylation of a subunit isoforms is critical for vertebrate vacuolar H+ -ATPase (V-ATPase) biosynthesis.
Q36228869NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila.
Q42152336O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation
Q38959357Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Q37779176Pathways for cytokine secretion.
Q24631095Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion
Q34221132RAB8 enhances TMEM205-mediated cisplatin resistance
Q35125206Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages
Q27313724Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages
Q40011006Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome
Q34429013Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
Q47932235Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin
Q42152599Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors
Q36290839Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction
Q24633280Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6
Q36959988Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages
Q36662457SNAREing immunity: the role of SNAREs in the immune system
Q28490040Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6.
Q34001889Shouts, whispers and the kiss of death: directional secretion in T cells
Q37929697Signaling through Toll-like receptor 4 and mast cell-dependent innate immunity responses
Q46419886Site-specific monitoring of N-Glycosylation profiles of a CTLA4-Fc-fusion protein from the secretory pathway to the extracellular environment.
Q40355358Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.
Q38930726Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.
Q37056616Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45
Q36812302Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells
Q30480503Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFalpha.
Q39578932Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.
Q28513189Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation
Q34285109Syntaxin 16 binds to cystic fibrosis transmembrane conductance regulator and regulates its membrane trafficking in epithelial cells
Q24298095Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes
Q45948164T cells use two directionally distinct pathways for cytokine secretion.
Q39042781The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages
Q38017191The SNARE Machinery in Mast Cell Secretion
Q36724456The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
Q40478060The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes.
Q33320073The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
Q37863216The regulation of endosome-to-Golgi retrograde transport by tethers and scaffolds.
Q34775469The role of the recycling endosome in regulating lamellipodia formation and macrophage migration.
Q38313362Transcriptional network dynamics in macrophage activation
Q58009882VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration
Q26851822Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells
Q58707587Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

Search more.