The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina

scientific article published on 10 April 2013

The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2013/658548
P932PMC publication ID3647581
P698PubMed publication ID23671886
P5875ResearchGate publication ID236741714

P2093author name stringGhulam Mohammad
Ahmed M Abu El-Asrar
Mohammad Mairaj Siddiquei
Mohammad Imtiaz Nawaz
P2860cites workNuclear localization and regulation of erk- and rsk-encoded protein kinasesQ24606980
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Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrierQ28235057
Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibitionQ28343572
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblastsQ28609143
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.Q30490801
Matrix metalloproteinases in human diabetic and nondiabetic vitreousQ32058683
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Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-RasQ34022639
Diabetic retinopathy: targeting vasoregressionQ34448837
Abrogation of MMP-9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage.Q35404674
Effect of cyclosporin-A on the blood--retinal barrier permeability in streptozotocin-induced diabetes.Q35609698
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivoQ35747338
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Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesisQ36299880
Retinal angiogenesis in development and diseaseQ36342347
Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathyQ36468930
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survivalQ37015135
Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1).Q37081039
Cellular signaling and potential new treatment targets in diabetic retinopathyQ37089750
Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9Q37241389
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miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-κB factor in human fibrosarcoma cellsQ39427500
Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathwayQ39594247
Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitroQ40712405
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.Q40857787
Diabetic retinopathy and inflammation: novel therapeutic targets.Q41012046
Role of inflammation in the pathogenesis of diabetic retinopathyQ41012127
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatmentQ42722726
The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathwayQ42962015
ERK1/2 signaling pathways involved in VEGF release in diabetic rat retinaQ43072986
Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stressQ43649151
VEGF-initiated blood-retinal barrier breakdown in early diabetes.Q43723423
Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitusQ43758841
Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat.Q43992605
High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina.Q44492248
Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytesQ44536960
A central role for inflammation in the pathogenesis of diabetic retinopathyQ44961996
Expression of apoptosis markers in the retinas of human subjects with diabetesQ44995675
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.Q45124417
Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microgliaQ46639180
Inhibition of GSK-3beta mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-kappaB in rat primary astrocyteQ46904500
Gelatinase B in proliferative vitreoretinal disordersQ47914078
Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.Q48515308
Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy.Q51542620
The role of Raf-1 kinase in diabetic retinopathy.Q54618543
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhageQ57584366
Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathyQ62019449
MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosisQ62843657
Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cellsQ73295316
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetesQ73640405
Diabetic retinopathyQ75217418
Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathyQ81473347
The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasisQ81493593
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectbiomarkerQ864574
P304page(s)658548
P577publication date2013-04-10
P1433published inJournal of Diabetes ResearchQ26841822
P1476titleThe ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina
P478volume2013

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cites work (P2860)
Q38365800Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?
Q33990723ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes.
Q53665301High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina.
Q64957438Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina.
Q37145629Modulation of angiogenesis by genetic manipulation of ATF4 in mouse model of oxygen-induced retinopathy [corrected].
Q37379837Poly (ADP-ribose) polymerase mediates diabetes-induced retinal neuropathy.
Q90728471Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy
Q35737656Serum Levels of IL-1 β , IL-6, TGF- β , and MMP-9 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP-9 in a New In Vitro Model of THP-1 Cells Activated by Stenting
Q37292151TNF-alpha levels in tears: a novel biomarker to assess the degree of diabetic retinopathy

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