Pathogenesis of insulin-dependent diabetes mellitus

scientific article published on January 1995

Pathogenesis of insulin-dependent diabetes mellitus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0950-351X(95)80803-5
P698PubMed publication ID7726797

P50authorIngrid KockumQ55446225
P2093author name stringSanjeevi CB
Lernmark A
Falorni A
P2860cites workT-cell receptor alpha, delta, and gamma chain genes in insulin-dependent diabetes mellitusQ73212685
A simple exact test for birth-order effectQ82343001
Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic miceQ93744670
Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigenQ24613961
Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes typeQ24617932
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficienciesQ28237011
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathwayQ28266815
DNA polymorphic haplotypes on the short arm of chromosome 11 and the inheritance of type I diabetes mellitusQ33672980
Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expressionQ33899197
Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylaseQ34111857
The susceptibility to insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3,4 heterozygotesQ34167588
Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitusQ34332860
gamma-Aminobutyric acid outside the mammalian brainQ34372326
Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetesQ34565013
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylaseQ34566310
A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ allelesQ34568059
Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritisQ34612436
Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitusQ35608673
Germ-line polymorphism of TCR genes and disease susceptibility--fact or hypothesis?Q36066955
Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. Reanalysis of dataQ36624271
Linkage analysis between the major histocompatibility system and insulin-dependent diabetes in families with patients in two consecutive generationsQ37021146
Insulin gene in diabetes. Analysis through RFLP.Q37580516
64,000 Mr autoantibodies as predictors of insulin-dependent diabetesQ68088864
Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetesQ68094557
T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetesQ68302812
Germline repertoire of T-cell receptor beta-chain genes in patients with insulin-dependent diabetes mellitusQ68306829
Study of cis and trans interactions between extended HLA-haplotypes in insulin-dependent diabetesQ68459636
A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetesQ68564203
HLA antigens and complotypes in insulin-dependent diabetes mellitusQ68729114
Genetics of IDDM: evidence for complex inheritance with HLAQ69205140
HLA and autoimmunity in North Indian type I (insulin-dependent) diabetic multiplex familiesQ69547405
HLA-DQ and T-cell receptor genes in insulin-dependent diabetes mellitusQ69899397
HLA-DQ system and insulin-dependent diabetes mellitus in Japanese: does it contribute to the development of IDDM as it does in Caucasians?Q69923679
Antipancreatic Cellular Hypersensitivity in Diabetes MellitusQ69939515
Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11Q70092826
Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)Q70113185
Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotypeQ70175885
Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitusQ70221438
Interaction of HLA and immunoglobulin antigens in Type 1 (insulin-dependent) diabetesQ70229962
Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin TreatmentQ70311233
Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB ratQ70339007
Immunoglobulin allotype markers and HLA DR genes in type I diabetes mellitusQ70495021
HLA and complement allotypes in Type 1 (insulin-dependent) diabetesQ70900912
Pathologic anatomy of the pancreas in juvenile diabetes mellitusQ71158858
Linkage disequilibrium between insulin-dependent diabetes and the Kidd blood group Jkb alleleQ72037511
Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetesQ72219638
Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetesQ72623993
HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitusQ72641298
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in JapaneseQ72661824
HLA and T-cell receptor genes in insulin-dependent diabetes mellitus.Q39463418
Islet cell antibodiesQ39482371
Insulin autoantibodies: their role in the pathogenesis of IDDM.Q39678759
Islet cell autoantigens in insulin-dependent diabetesQ40305187
The epidemiologic approach to studies of association between HLA and disease. II. Estimation of absolute risks, etiologic and preventive fractionQ40342574
Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitusQ40817599
Islet-Cell-Surface Antibodies in Juvenile Diabetes MellitusQ40913898
Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ.Q40921608
Genetics of juvenile diabetes mellitus. A recessive gene closely linked to HLA D and with 50 per cent penetranceQ41056525
HLA-DR and the 5' insulin gene polymorphism in insulin-dependent diabetesQ41172699
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndromeQ41196484
HLA heterozygosity in insulin-dependent diabetes is most frequent at the DQ locusQ41229004
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I moleculesQ41594402
Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentationQ41594408
Transport protein genes in the murine MHC: possible implications for antigen processingQ41710121
Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibodyQ41723037
Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control childrenQ43511735
TNF-alpha gene polymorphisms in type 1 (insulin-dependent) diabetes mellitusQ43529179
T-cell receptor beta-subunit gene polymorphism and autoimmune diseaseQ43679192
Genetic analysis of autoimmune type 1 diabetes mellitus in miceQ44110103
Allelic T-cell receptor alpha complexes have little or no influence on susceptibility to type 1 diabetesQ44494018
Tumour necrosis factor-beta gene RFLP alleles in Finnish IDDM haplotypes. The Childhood Diabetes in Finland (DiMe) Study GroupQ45114891
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetesQ46512140
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping.Q46858133
Polygenic control of autoimmune diabetes in nonobese diabetic miceQ48107213
Detection of autoantibodies to the 65-kD isoform of glutamate decarboxylase by radioimmunoassayQ48108270
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.Q48112618
Polymorphism of the class II gene of rat major histocompatibility complex, RT1: partial sequence comparison of the first domain of the RT1.B beta 1 allelesQ48240406
The epidemiologic approach to studies of association between HLA and disease. I. The basic measures, concepts and estimation procedures.Q52722702
HL-A antigens and diabetes mellitus.Q53741461
Histocompatibility (HL-A) Antigens, Lymphocytotoxic Antibodies and Tissue Antibodies in Patients with Diabetes MellitusQ53919094
Genetic dissection of autoimmune type I diabetes in the BB rat.Q54264003
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.Q55066037
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibilityQ56524301
A unified hypothesis for the complex genetics of HLA associations with IDDMQ57159217
Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotesQ57159347
Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitusQ57265410
HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individualsQ57449712
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteinsQ57449719
Polymorphic Analysis of the Human MHC-Linked Heat Shock Protein 70 (HSP70-2) and HSP70-Hom Genes in Insulin-Dependent Diabetes Mellitus (IDDM)Q58201347
Interactive effect of HLA and Gm tested in a study of 135 juvenile insulin-dependent diabetic familiesQ58485967
Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter geneQ60609097
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDMQ61861656
Predictive value of islet cell and insulin autoantibodies for Type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control childrenQ61861661
A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes MellitusQ67223651
Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitusQ67237183
The increased frequency of the Lewis negative blood group in a diabetic populationQ67367516
Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetesQ67513769
Sibling Method for Detecting HLA-linked genes in diseaseQ67561482
A consensus repeat sequence from the human insulin gene linked polymorphic region adopts multiple quadriplex DNA structures in vitroQ67593791
P433issue1
P304page(s)25-46
P577publication date1995-01-01
P1433published inBailliere's clinical endocrinology and metabolismQ27709241
P1476titlePathogenesis of insulin-dependent diabetes mellitus
P478volume9

Reverse relations

cites work (P2860)
Q37363218Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect
Q45057620Conformation-dependent GAD65 autoantibodies in diabetes
Q37716900DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology
Q38353381Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM.
Q73056083Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast
Q33901714Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1
Q81066769The immunogenetics of autoimmune diabetes and autoimmune thyroid disease
Q37310687Treatment of diabetic rats with encapsulated islets

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