Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells

scientific article published on September 2004

Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJC.6602055
P932PMC publication ID2747713
P698PubMed publication ID15316561
P5875ResearchGate publication ID8394138

P2093author name stringJ J Sauk
N G Nikitakis
H Siavash
P2860cites workPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
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The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcriptionQ28208036
Cyclopentenone prostaglandins: new insights on biological activities and cellular targetsQ28619819
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A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgammaQ31938741
SOCS: suppressors of cytokine signallingQ31994132
Negative regulation of the JAK/STAT pathwayQ33539658
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STAT signaling in head and neck cancerQ33941351
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Stat proteins and oncogenesisQ34627064
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivoQ35676433
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell linesQ36239779
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinasesQ36307242
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitroQ37385294
Differential function of STAT5 isoforms in head and neck cancer growth controlQ38289837
15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cellsQ38292542
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activityQ38312043
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neckQ38354192
MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxQ40726966
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LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.Q40910796
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Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.Q41012233
Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2.Q42483553
Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stressQ43559588
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cellsQ43649346
15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors.Q43690457
Early de novo gene expression is required for 15-deoxy-Delta 12,14-prostaglandin J2-induced apoptosis in breast cancer cellsQ43773214
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma linesQ43891663
Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cellsQ43955953
15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cellsQ44195479
15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in gliaQ44313350
Involvement of c‐jun N‐terminal kinase activation in 15‐deoxy‐δ12,14‐prostaglandin J2–and prostaglandin A1–induced apoptosis in AGS gastric epithelial cellsQ44421564
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.Q53654970
Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cellsQ70670010
Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokinesQ73042572
Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancerQ73519290
Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cellsQ73574304
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cellsQ74121752
STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivoQ74649686
The role of c-Myc and heat shock protein 70 in human hepatocarcinoma Hep3B cells during apoptosis induced by prostaglandin A2/Delta12-prostaglandin J2Q77587342
Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancerQ77948466
15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cellsQ78202614
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1074-1080
P577publication date2004-09-01
P1433published inBritish Journal of CancerQ326309
P1476titleAbrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells
P478volume91

Reverse relations

cites work (P2860)
Q3919742215-Deoxy-Δ12,14-Prostaglandin J2 Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells
Q35148085Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells
Q35060321Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
Q28292907Omega-3 Fatty Acids and PPARgamma in Cancer
Q39882795Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding
Q34605234The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac

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