Ras signaling and NF1.

scientific article published on February 1995

Ras signaling and NF1. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0959-437X(95)90053-5
P698PubMed publication ID7749326

P2093author name stringMcCormick F
P2860cites workType 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patientsQ34166560
The regulation and function of p21ras in T cellsQ36286249
Regulation of membrane turnover by ras proteinsQ39677635
Von Recklinghausen neurofibromatosisQ40262766
Biochemical and biological properties of the human N-ras p21 proteinQ40658346
Activators and effectors of ras p21 proteinsQ40757563
MAP kinase kinase kinase, MAP kinase kinase and MAP kinaseQ40757575
The neurofibromatosis type 1 geneQ40890806
Suppression of c-ras transformation by GTPase-activating proteinQ41205326
Neurofibromatosis type 1 gene mutations in neuroblastomaQ41579794
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosisQ42806305
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiaeQ43515231
Differential regulation of rasGAP and neurofibromatosis gene product activitiesQ43668633
The effect of GTPase activating protein upon ras is inhibited by mitogenically responsive lipidsQ45289350
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinaseQ46204426
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disordersQ46413091
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patientsQ24294421
Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleusQ24299756
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1Q24309607
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteinsQ24324729
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1Q24595034
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
Bcl-2 associates with the ras-related protein R-ras p23Q28256068
Proteins regulating Ras and its relativesQ28257295
Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinaseQ28269621
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutationsQ28300121
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21Q28609120
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformationQ29616396
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membraneQ29618478
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Activation of Raf as a result of recruitment to the plasma membraneQ29618481
Phosphatidylinositol-3-OH kinase as a direct target of RasQ29620177
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.Q33256073
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitroQ33292215
P433issue1
P304page(s)51-55
P577publication date1995-02-01
P1433published inCurrent Opinion in Genetics & DevelopmentQ13505684
P1476titleRas signaling and NF1.
P478volume5

Reverse relations

cites work (P2860)
Q47072734A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
Q77315281A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein
Q46292236Bone mineral metabolism in patients with neurofibromatosis type 1 (von Recklingausen disease).
Q34253927Decreased bone mineralization in children with Noonan syndrome: another consequence of dysregulated RAS MAPKinase pathway?
Q80063140Detection of novel NF1 mutations and rapid mutation prescreening with Pyrosequencing
Q24304570Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast
Q50671106Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia.
Q47620432Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases
Q28602124Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep
Q82452891Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway
Q47072868In vivo functional analysis of Drosophila Gap1: involvement of Ca2+ and IP4 regulation
Q33604218Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
Q38563753Lessons from the p53 mutant mouse
Q64060975Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies
Q36497139MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.
Q41099828Mechanisms of carcinogenesis and the mutant mouse
Q104135136MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK
Q74736163Molecular genetics of renal cell carcinoma
Q33535727Neurofibromatosis type 1 peripheral nerve tumors: aberrant activation of the Ras pathway
Q28279834Neurofibromatosis type 1: piecing the puzzle together
Q80604617Neurofibromatosis with gastrointestinal stromal tumors: insights into the association
Q52170341Neurofibromin progress on the fly.
Q79605117Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy
Q35944775Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation
Q36452994Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster
Q35987649Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.
Q48057194Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control
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Q55477300Ras activation in astrocytomas and neurofibromas.
Q41101646Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively
Q37061120Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes
Q36373503Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.
Q40872114Signal transduction pathways and their relevance in human astrocytomas
Q77343239The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas
Q41462850Towards a unified model of tumor suppression: lessons learned from the human patched gene
Q28584833Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

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