Biochemical properties and biological effects of p53.

scientific article published on February 1995

Biochemical properties and biological effects of p53. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0959-437X(95)90058-6
P698PubMed publication ID7749331

P2093author name stringOren M
Haffner R
P2860cites workThe p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexesQ24608783
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
High-resolution structure of the oligomerization domain of p53 by multidimensional NMRQ27730817
WAF1, a potential mediator of p53 tumor suppressionQ27861121
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathwaysQ36647845
p53-mediated cell death: relationship to cell cycle controlQ36675212
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Q38313400
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 proteinQ38313694
Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppressionQ40657202
How loops, beta sheets, and alpha helices help us to understand p53.Q40694267
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.Q40791236
Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.Q40792701
The tumor suppressor genesQ40856821
p53-catalyzed annealing of complementary single-stranded nucleic acidsQ40873109
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genesQ41454039
Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cellsQ41483255
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.Q41563742
The effects of SV40 large T antigen and p53 on nuclear transport capacity in BALB/c 3T3 cellsQ42796110
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.Q45993768
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.Q52214399
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.Q52512094
p53 domains: identification and characterization of two autonomous DNA-binding regions.Q52544476
Transcriptional activation by p53 correlates with suppression of growth but not transformation.Q53468212
p53, guardian of RbQ59068113
No room at the p53 innQ59093958
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1Q71644976
p53-dependent apoptosis suppresses tumor growth and progression in vivoQ72149266
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spotsQ72693767
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in developmentQ72718760
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53Q72871721
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)84-90
P577publication date1995-02-01
P1433published inCurrent Opinion in Genetics & DevelopmentQ13505684
P1476titleBiochemical properties and biological effects of p53.
P478volume5

Reverse relations

cites work (P2860)
Q34761984A functional p53-responsive intronic promoter is contained within the humanmdm2gene
Q40019792A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
Q48058940A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe
Q28574858A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis
Q36546016Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.
Q41049816Alteration of p53 protein in C3H/10T1/2 cells morphologically transformed by gamma-rays in stationary phase.
Q73928775Analysis of bcl-2 in sporadic breast carcinoma
Q41076902Anti-apoptotic activity of low levels of wild-type p53.
Q78192930Anti-apoptotic activity of p53 maps to the COOH-terminal domain and is retained in a highly oncogenic natural mutant
Q41290168Apoptosis and gastrointestinal pharmacology.
Q50974402Apoptosis in steroidogenic cells: structure-function analysis.
Q41515231Apoptosis: an overview of the process and its relevance in disease.
Q48482815BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study
Q35847043Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
Q40889956Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells
Q36019930Conformation-dependent phosphorylation of p53.
Q48027293DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning
Q59083516DAP kinase links the control of apoptosis to metastasis
Q28277623Death-associated proteins: from gene identification to the analysis of their apoptotic and tumour suppressive functions
Q42828172Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice
Q31396053Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture
Q41157654Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
Q39841731Effect of inducible expressed human cytomegalovirus immediate early 86 protein on cell apoptosis
Q73401624Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice
Q53625566Effects of maternal uninephrectomy on the development of fetal rat kidney: apoptosis and the expression of oncogenes.
Q24633970FinO is an RNA chaperone that facilitates sense-antisense RNA interactions
Q36561445Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.
Q35633059Functions of pRb and p53: what's the connection?
Q41037063Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
Q73283449HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX
Q41204966Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway
Q39872769Human cytomegalovirus IE1 and IE2 proteins block apoptosis
Q73271533Human polyomavirus BK (BKV) and neuroblastoma: mechanisms of oncogenic action and possible strategy for novel treatment
Q53461564Induction of apoptosis in HeLa cells by trans-activation-deficient p53
Q41071070Induction of p53 protein expression by sodium arsenite
Q44123359Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells
Q59098941Life (and death) in a malignant tumour
Q37474256MEKK1/JNK signaling stabilizes and activates p53.
Q41290133Molecular and clinical aspects of apoptosis
Q27851503Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer
Q33780955Noise cancellation: viral fine tuning of the cellular environment for its own genome replication.
Q23915398PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo
Q23918117Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells
Q33834813Phenotype vs genotype in the evolution of astrocytic brain tumors
Q34459889Protein-protein interfaces: mimics and inhibitors
Q38327560RETRACTED: Alteration of p73 in acute myelogenous leukemia
Q74355214RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome
Q41101646Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively
Q28243213Recruitment of p300/CBP in p53-dependent signal pathways
Q40902101Reduced expression of p33(ING1) and the relationship with p53 expression in human gastric cancer
Q33828413Regulation of MCP-1 chemokine transcription by p53
Q38352373Regulation of mutant p53 temperature-sensitive DNA binding.
Q36556427Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor
Q24552501Repression of RNA polymerase I transcription by the tumor suppressor p53
Q24336020Repression of p53-mediated transcription by MDM2: a dual mechanism
Q41589773Role of extracellular matrix, growth factors and proto-oncogenes in metanephric development
Q54569740Role of ribonucleotide reductase and deoxynucleotide pools in the oxygen-dependent control of DNA replication in Ehrlich ascites cells.
Q33781230Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.
Q40953874Strategies and applications of DNA level diagnosis in genetic diseases: past experiences and future directions.
Q36292987Suppression of tumorigenic and metastatic potentials of human melanoma cell lines by mutated (143 Val-Ala) p53.
Q24551106Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response
Q74486048The expression of p53, c-erbB-1 and c-erbB-2 molecules and their correlation with prognostic markers in patients with head and neck tumors
Q77144377The immunomodulating glycoprotein extract from Klebsiella pneumoniae RU 41740 exerts a suppressive effect on human monocyte death by apoptosis
Q42454112The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.
Q41099842The recognition of DNA damage
Q40023735Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
Q35903285Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
Q33886271Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
Q35878052Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax
Q41625163Tumor suppressor genes and human cancer
Q40752768Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.
Q52192096p53 activity is essential for normal development in Xenopus.
Q33888115p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53
Q48799379p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.
Q43643342p53 gene alteration and protein expression in Iranian women with infiltrative ductal breast carcinoma.
Q42645736p53 is a general repressor of RNA polymerase III transcription
Q42468055p53 represses ribosomal gene transcription
Q74185669p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following gamma-irradiation
Q33868917p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding
Q41091013p73 is a simian [correction of human] p53-related protein that can induce apoptosis

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