Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction

scientific article published on September 2004

Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1013013375
P356DOI10.1038/SJ.ONC.1207923
P698PubMed publication ID15273725
P5875ResearchGate publication ID8435468

P2093author name stringGregory H Enders
Hiroshi Nakagawa
Hideki Harada
Cameron N Johnstone
Munenori Takaoka
Claudia D Andl
Oliver G Opitz
Kenji Oyama
Ben Rhoades
Therese B Deramaudt
P2860cites workPremature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingQ22003910
PML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivoQ24318871
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Atmospheric carbon dioxide concentrations over the past 60 million yearsQ28144787
Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapseQ28185780
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genesQ28343950
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
ras genesQ29547799
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressorQ33961286
Role of p14(ARF) in replicative and induced senescence of human fibroblastsQ34012414
Specific protection against breast cancers by cyclin D1 ablationQ34082446
Oncogenic ras and p53 cooperate to induce cellular senescenceQ34279104
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblastsQ34286570
A mouse model of human oral-esophageal cancerQ34796816
Senescence of human fibroblasts induced by oncogenic Raf.Q35210205
Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescenceQ35805158
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformationQ35861554
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescenceQ39647398
Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogeneQ40273505
High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human FibroblastsQ40620874
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular contextQ40637553
UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent mannerQ40964447
The cat and mouse games that genes, viruses, and cells playQ41367391
Immunohistologic detection of the epidermal growth factor receptor in human esophageal squamous cell carcinomaQ42466142
Loss of p16Ink4a confers susceptibility to metastatic melanoma in miceQ43729271
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesisQ43729274
p19ARF-induced p53-independent apoptosis largely occurs through BAX.Q44677597
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesisQ46492957
Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogeneQ47243620
Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence.Q47277811
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.Q47745236
In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.Q52834055
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenesQ53374378
p19ARF links the tumour suppressor p53 to RasQ57562848
A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative StressQ59297314
Evidence for a p53‐independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cellsQ71647788
Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplificationQ72078811
H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanismQ73501420
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)6760-6768
P577publication date2004-09-01
P1433published inOncogeneQ1568657
P1476titleHa-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction
P478volume23

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cites work (P2860)
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