Impact of bacterial load on pharmacodynamics and susceptibility breakpoints for tigecycline and Klebsiella pneumoniae

scientific article published on 19 September 2016

Impact of bacterial load on pharmacodynamics and susceptibility breakpoints for tigecycline and Klebsiella pneumoniae is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JAC/DKW354
P698PubMed publication ID27650184

P50authorAthanassios TsakrisQ90648868
P2093author name stringJoseph Meletiadis
George L Daikos
Johan W Mouton
Loukia Zerva
Sophia Vourli
Marilena Tsala
P2860cites workTigecycline: first of a new class of antimicrobial agentsQ28253736
High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteriaQ33754471
Tissue Penetration and Pharmacokinetics of Tigecycline in Diabetic Patients with Chronic Wound Infections Described by Using In Vivo MicrodialysisQ34309522
Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomesQ34320945
Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsiesQ35532816
Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumoniaQ35666608
Pharmacodynamic effects of simulated standard doses of antifungal drugs against Aspergillus species in a new in vitro pharmacokinetic/pharmacodynamic modelQ35666627
Exposure-response analyses of tigecycline efficacy in patients with complicated skin and skin-structure infectionsQ35840772
The pharmacokinetic and pharmacodynamic profile of tigecyclineQ36218318
Exposure-response analyses of tigecycline efficacy in patients with complicated intra-abdominal infectionsQ36422712
In vivo pharmacodynamic profile of tigecycline against phenotypically diverse Escherichia coli and Klebsiella pneumoniae isolatesQ37247732
Antimicrobial susceptibility among gram-negative isolates collected in the USA between 2005 and 2011 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.).Q37364437
Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecyclineQ37864882
Quantitative aspects of septicemiaQ37946740
Tigecycline: an updateQ38077344
Confronting carbapenemase-producing Klebsiella pneumoniaeQ38135903
Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungsQ39953659
Pharmacokinetic-pharmacodynamic modelling of meropenem against VIM-producing Klebsiella pneumoniae isolates: clinical implicationsQ40177874
Validation of different techniques for the diagnosis of ventilator-associated pneumonia. Comparison with immediate postmortem pulmonary biopsyQ40704822
Tetracyclines: antibiotic action, uptake, and resistance mechanismsQ41004630
Tigecycline activity tested against carbapenem-resistant Enterobacteriaceae from 18 European nations: results from the SENTRY surveillance program (2010-2013).Q41113428
In Vitro Pharmacodynamics of Simulated Pulmonary Exposures of Tigecycline Alone and in Combination against Klebsiella pneumoniae Isolates Producing a KPC CarbapenemaseQ41858894
Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: pooled results from 8 phase III clinical trialsQ42643577
Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogensQ46062198
Optimal tigecycline dosage regimen is urgently needed: results from a pharmacokinetic/pharmacodynamic analysis of tigecycline by Monte Carlo simulationQ46108407
Results of a multicenter, controlled, randomized clinical trial evaluating the combination of piperacillin/tazobactam and tigecycline in high-risk hematologic patients with cancer with febrile neutropeniaQ50802868
Efficacies of colistin and tigecycline in mice with experimental pneumonia due to NDM-1-producing strains of Klebsiella pneumoniae and Escherichia coli.Q54346626
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectKlebsiella pneumoniaeQ132592
pharmacodynamicsQ725307
P304page(s)172-180
P577publication date2016-09-19
P1433published inJournal of Antimicrobial ChemotherapyQ6294770
P1476titleImpact of bacterial load on pharmacodynamics and susceptibility breakpoints for tigecycline and Klebsiella pneumoniae
P478volume72

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Q90073378Successful High-Dosage Monotherapy of Tigecycline in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Ratscites workP2860

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