The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.

scientific article published on March 2004

The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016285082
P356DOI10.1023/B:NEON.0000021897.53969.CA
P698PubMed publication ID15072465

P50authorUlf NestlerQ40366699
Fernando Siller-LópezQ42729207
Alona MuzikanskyQ105531784
Anat Stemmer-RachamimovQ111143076
P2093author name stringE Antonio Chiocca
Fred H Hochberg
Arnab Chakravarti
Hiroaki Wakimoto
Estuardo Aguilar-Cordova
Laura K Aguilar
P2860cites workSubstantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovirQ32060420
Prodrug activation enzymes in cancer gene therapyQ33968115
When X-ray-inducible proteins meet DNA double strand break repairQ34418340
Necrosis and glioblastoma: a friend or a foe? A review and a hypothesisQ34786608
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivoQ35152561
Adenoviral-mediated suicide gene therapy for ovarian cancerQ40612020
Foamy virus vectors for suicide gene therapyQ41072221
The non-variation in radiosensitivity of different proliferative states of human glioma cells.Q41253664
Cell and environment interactions in tumor microregions: the multicell spheroid modelQ41280817
Role of necrosis in regulating the growth saturation of multicellular spheroidsQ41435384
Quantitative comparison between the transplantability of human and murine tumors into the brain of NCr/Sed-nu/nu nude and severe combined immunodeficient miceQ41520619
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in ratsQ42835030
Enhanced therapeutic effect of HSV-tk+GCV gene therapy and ionizing radiation for prostate cancerQ43586837
Enhanced therapeutic effect of multiple injections of HSV-TK + GCV gene therapy in combination with ionizing radiation in a mouse mammary tumor modelQ43796443
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administrationQ43876009
Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responsesQ43941683
Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat).Q45882064
Treatment of recurrent or progressive malignant glioma with a recombinant adenovirus expressing human interferon-beta (H5.010CMVhIFN-beta): a phase I trialQ49027977
Quiescence in S-phase and G1 arrest induced by irradiation and/or hyperthermia in six human tumour cell lines of different p53 status.Q55475510
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis.Q55476348
Hypofractionated radiation induces a decrease in cell proliferation but no histological damage to organotypic multicellular spheroids of human glioblastomas.Q55478566
Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas.Q55479920
Delayed Initiation of DNA Synthesis in Irradiated Human Diploid CellsQ59093823
Distribution, persistency, toxicity, and lack of replication of an E1A-deficient adenoviral vector after intracardiac delivery in the cotton ratQ64381682
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studiesQ64382810
Induction of mRNA for tumor necrosis factor-alpha and interleukin-1 beta in mice brain, spleen and liver in an animal model of Shigella-related seizuresQ73773648
P433issue1-2
P921main subjectadaptive radiation therapyQ180507
AdenoviridaeQ193447
glioblastomaQ282142
gene therapyQ213901
xenograftQ64148587
P304page(s)177-188
P577publication date2004-03-01
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleThe combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects
P478volume67