First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin

scientific article published on April 2002

First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/ANNONC/MDF089
P698PubMed publication ID12056707
P5875ResearchGate publication ID11316843

P50authorChris TwelvesQ47067174
P2093author name stringJ Marshall
J Maroun
J Cassidy
U Graeven
E Van Cutsem
M Boyer
P Hoff
R L Schilsky
R Rosso
E Bajetta
B Osterwalder
P Rougier
R Bugat
A Garin
U Burger
G Pérez-Manga
Capecitabine Colorectal Cancer Study Group
J McKendric
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
capecitabineQ420207
metastatic colon cancerQ108566365
P304page(s)566-575
P577publication date2002-04-01
P1433published inAnnals of OncologyQ326122
P1476titleFirst-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
P478volume13

Reverse relations

cites work (P2860)
Q33425826A Muti-center, Randomized Phase II Study of Oxaliplatin and S-1 versus Capecitabine and Oxaliplatin in Patients with Metastatic Colorectal Cancer
Q34334959A Phase I Study of Sunitinib Plus Capecitabine in Patients With Advanced Solid Tumors
Q90481360A Study of the S-1 or Capecitabine as First-line Regimen in Patients with Metastatic Colorectal Cancer: A Real World Study
Q28652720A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS
Q37225701A multicenter phase II study of the combination of oxaliplatin, irinotecan and capecitabine in the first-line treatment of metastatic colorectal cancer
Q36616386A phase I clinical and pharmacokinetic study of capecitabine (Xeloda) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours
Q36694899A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer
Q33420046A phase II study of capecitabine and oral leucovorin as a third-line chemotherapy in patients with metastatic colorectal cancer
Q36614036A phase II study of capecitabine plus 3-weekly oxaliplatin as first-line therapy for patients with advanced gastric cancer
Q33366181A phase II study of capecitabine plus oxaliplatin (XELOX): a new first-line option in metastatic colorectal cancer
Q57896517A phase II study of capecitabine, irinotecan, and bevacizumab in patients with previously untreated metastatic colorectal cancer
Q36614004A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/metastatic colorectal cancer
Q36671560A phase II trial of capecitabine (Xeloda®) in recurrent ovarian cancer
Q45023409A phase II trial of capecitabine in previously untreated patients with advanced and/or metastatic gastric cancer.
Q46902871A pilot phase II study of capecitabine plus cisplatin in the treatment of recurrent carcinoma of the uterine cervix
Q46847847A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer
Q36858273A randomised multicentre phase II trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer
Q34609932A randomized multicenter phase II study comparing capecitabine with irinotecan or cisplatin in metastatic adenocarcinoma of the stomach or esophagogastric junction
Q53650086A retrospective observational study on the use of capecitabine in patients with severe renal impairment (GFR <30 mL/min) and end stage renal disease on hemodialysis.
Q47291560A review of capecitabine-based adjuvant therapy for gastric cancer in the Chinese population
Q36192043Accurate measurement of individual glomerular filtration rate in cancer patients: an ongoing challenge
Q37270640Adherence and Patients' Experiences with the Use of Capecitabine in Daily Practice
Q37029891Adherence management for patients with cancer taking capecitabine: a prospective two-arm cohort study
Q35202155Adjuvant therapy for rectal cancer--the transatlantic view
Q46502244Altered dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy
Q38363625An exploratory study to identify risk factors for the development of capecitabine-induced Palmar Plantar Erythrodysesthesia (PPE).
Q42406916An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?
Q80496977Analysis of risk factors for severe adverse effects of oral 5-fluorouracil S-1 in patients with advanced gastric cancer
Q88867253Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer
Q42243044Balancing the efficacy and toxicity of chemotherapy in colorectal cancer
Q46933040Benefits and risks of palliative capecitabine based therapy to elderly patients with advanced colorectal cancer: Danish single centre experiences
Q38617495Bevacizumab in combination with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for first-line and maintenance treatment of metastatic colorectal cancer
Q36611697Bevacizumab-containing regimens after cetuximab failure in Kras wild-type metastatic colorectal carcinoma.
Q36792721Candidate mechanisms for capecitabine-related hand-foot syndrome
Q33393811Capecitabine "metronomic" chemotherapy for palliative treatment of elderly patients with advanced gastric cancer after fluoropyrimidine-based chemotherapy
Q37122339Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients
Q35819857Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer.
Q37077342Capecitabine and timing of radiotherapy during preoperative chemoradiation for rectal cancer.
Q38825147Capecitabine for treating head and neck cancer
Q44323778Capecitabine in combination with docetaxel and epirubicin in patients with previously untreated, advanced breast carcinoma
Q37400585Capecitabine in combination with irinotecan (XELIRI), administered as a 2-weekly schedule, as first-line chemotherapy for patients with metastatic colorectal cancer: a phase II study of the Spanish GOTI group
Q33361603Capecitabine in combination with mitomycin C in patients with gastrointestinal cancer: results of an extended multicentre phase-I trial
Q34236005Capecitabine in gastric cancer
Q36429425Capecitabine in the treatment of colorectal cancer
Q44176817Capecitabine named-patient programme for patients with advanced breast cancer. the UK experience
Q41186022Capecitabine plus oxaliplatin (XELOX) compared with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in advanced gastric cancer: meta-analysis of randomized controlled trials
Q34639725Capecitabine plus oxaliplatin compared with 5-fluorouracil plus oxaliplatin in metastatic colorectal cancer: Meta-analysis of randomized controlled trials
Q37085987Capecitabine plus oxaliplatin for the treatment of colorectal cancer.
Q34632080Capecitabine versus 5-fluorouracil/folinic acid as adjuvant therapy for stage III colon cancer: final results from the X-ACT trial with analysis by age and preliminary evidence of a pharmacodynamic marker of efficacy
Q36957572Capecitabine vs continuous infusion 5-FU in neoadjuvant treatment of rectal cancer. A retrospective review
Q43260575Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer
Q53569593Capecitabine-induced headache responding to diltiazem.
Q46496664Capecitabine-induced oromandibular dystonia: a case report and literature review.
Q86087703Capecitabine-induced terminal ileitis
Q45174619Capecitabine: fixed daily dose and continuous (noncyclic) dosing schedule
Q34494672Chemotherapy for colorectal cancer
Q37602291Chemotherapy, which drugs and when
Q80477531Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes
Q24611758Clinical management of localized colon cancer with capecitabine
Q35039124Colorectal cancer in the elderly: is palliative chemotherapy of value?
Q35875388Combined modality therapy for rectal cancer.
Q35083334Comparison of the efficacy and safety of S-1-based and capecitabine-based regimens in gastrointestinal cancer: a meta-analysis
Q37485627Compliance and effective management of the hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy
Q39063211Concurrent capecitabine and upper abdominal radiation therapy is well tolerated
Q37269696Cost-effectiveness analysis of XELOX for metastatic colorectal cancer based on the NO16966 and NO16967 trials
Q43296470Cost-effectiveness analysis of capecitabine compared with bolus 5-fluorouracil/l-leucovorin for the adjuvant treatment of colon cancer in Japan.
Q46132535Costs associated with complications are lower with capecitabine than with 5-fluorouracil in patients with colorectal cancer
Q45268020Costs of treatment of colorectal cancer in different settings in Germany
Q92242538Current Treatment Strategies for Elderly Patients with Metastatic Colon Cancer
Q36960766Current and emerging trends in the treatment of early-stage colorectal cancer: importance of a multidisciplinary approach
Q30244769Decision-making in geriatric oncology: systemic treatment considerations for older adults with colon cancer
Q36936972Dihydro pyrimidine dehydrogenase deficiency in patients treated with capecitabine based regimens: a tertiary care centre experience
Q56391087Dose calculation of anticancer drugs
Q36306269Drug Insight: Metastatic colorectal cancer--oral fluoropyrimidines and new perspectives in the adjuvant setting
Q38845891Drug-induced hepatotoxicity in cancer patients - implication for treatment
Q37729193Economic evaluation of capecitabine as adjuvant or metastatic therapy in colorectal cancer
Q37325560Effect of age on drug metabolism in women with breast cancer
Q37403462Emerging role of capecitabine in gastric cancer
Q36151475Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study
Q28534572Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines
Q43289305Feasibility and efficacy of capecitabine and FOLFIRI in patients aged 65 years and older with advanced colorectal cancer: a retrospective analysis
Q37108258First-line cetuximab-based chemotherapies for patients with advanced or metastatic KRAS wild-type colorectal cancer
Q36760297First-line treatment strategies for elderly patients with metastatic colorectal cancer
Q41844636Hand-foot syndrome with scleroderma-like change induced by the oral capecitabine: a case report
Q35919188Hypokalemia secondary to capecitabine: a hidden toxicity?
Q33825180Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses
Q40997435Impact of hand-foot skin reaction on treatment outcome in patients receiving capecitabine plus erlotinib for advanced pancreatic cancer: a subgroup analysis from AIO-PK0104.
Q37355866Incidence and risk factors for capecitabine-induced symptomatic cardiotoxicity: a retrospective study of 452 consecutive patients with metastatic breast cancer.
Q100455599Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?
Q35620769Integrating oxaliplatin and capecitabine in adjuvant therapy of high-risk colorectal cancer
Q92356857Interleukin-17A polymorphisms predict the response and development of tolerance to FOLFOX chemotherapy in colorectal cancer treatment
Q24235217Interventions for preventing oral mucositis for patients with cancer receiving treatment
Q24235482Interventions for preventing oral mucositis for patients with cancer receiving treatment
Q24243046Interventions for preventing oral mucositis for patients with cancer receiving treatment
Q24246310Interventions for preventing oral mucositis for patients with cancer receiving treatment
Q37355937Lapatinib in patients with metastatic breast cancer following initial treatment with trastuzumab: an economic analysis from the Brazilian public health care perspective
Q37339474Long-term oncologic outcomes of neoadjuvant concurrent chemoradiotherapy with capecitabine and radical surgery in locally advanced rectal cancer: 10-year experiences at a single institution
Q34202729Long-term results from a randomized phase II trial of neoadjuvant combined-modality therapy for locally advanced rectal cancer
Q35733020Low-dose capecitabine adjuvant chemotherapy in elderly stage II/III colorectal cancer patients (LC-ACEC): study protocol for a randomized controlled trial
Q33967458Maintenance therapy with capecitabine in patients with locally advanced unresectable pancreatic adenocarcinoma
Q27026129Management of locally advanced and metastatic colon cancer in elderly patients
Q38032558Metastatic colorectal cancer in the elderly: An overview of the systemic treatment modalities (Review).
Q36920617Metastatic colorectal cancer: current systemic treatment options.
Q35623320Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer
Q92592439Modulation of capecitabine administration to improve continuity of adjuvant chemotherapy for patients with colorectal cancer: A phase II study
Q64071667Molecular biomarkers and histological parameters impact on survival and response to first- line systemic therapy of metastatic colorectal cancer patients
Q34500981Neoadjuvant capecitabine, bevacizumab and radiotherapy for locally advanced rectal cancer: results of a single-institute Phase I study
Q34006430Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study
Q35741932New systemic frontline treatment for metastatic colorectal carcinoma
Q37875058Optimal management of metastatic colorectal cancer: current status
Q44849722Oral 5-FU and digestive cancers
Q35615863Oral Xeloda plus bi-platinu two-way combined chemotherapy in treatment of advanced gastrointestinal malignancies
Q30913489Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials
Q30251387Oral drugs in the treatment of metastatic colorectal cancer
Q38633004Oral therapy for nonmelanoma skin cancer in patients with advanced disease and large tumor burden: a review of the literature with focus on a new generation of targeted therapies
Q24239911Oral versus intravenous fluoropyrimidines for colorectal cancer
Q38650502Oral versus intravenous fluoropyrimidines for colorectal cancer.
Q46628300Outcome of first line systemic treatment in elderly compared to younger patients with metastatic colorectal cancer: a retrospective analysis of the CAIRO and CAIRO2 studies of the Dutch Colorectal Cancer Group (DCCG).
Q36288022Oxaliplatin/capecitabine vs oxaliplatin/infusional 5-FU in advanced colorectal cancer: the MRC COIN trial.
Q36989058Palliative chemotherapy in advanced colorectal cancer patients 80 years of age and older
Q35444531Patients' self-reported adherence to capecitabine on XELOX treatment in metastatic colorectal cancer: findings from a retrospective cohort analysis
Q30227039Perceptions and Experiences of Patients Receiving Oral Chemotherapy
Q78601142Pharmacoepidemiology and drug safety
Q38072718Pharmacokinetic evaluation of capecitabine in breast cancer
Q36201411Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas
Q36201465Phase I/II trial of capecitabine, oxaliplatin, and irinotecan in combination with bevacizumab in first line treatment of metastatic colorectal cancer
Q41559464Phase I/II trial of dose-reduced capecitabine in elderly patients with advanced colorectal cancer.
Q35482173Phase II multi-center clinical study on using S-1 to treat advanced breast cancer after resistance to anthracycline and taxane drugs in Chinese patients
Q36695781Phase II study of a triplet regimen in advanced colorectal cancer using methotrexate, oxaliplatin and 5-fluorouracil
Q35638434Phase II study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced pancreatic cancer
Q36697132Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancer
Q33386361Phase II study of capecitabine plus oxaliplatin (XELOX) as first-line treatment and followed by maintenance of capecitabine in patients with metastatic colorectal cancer
Q34746009Phase II study of single agent capecitabine in the treatment of metastatic non-pancreatic neuroendocrine tumours
Q33370303Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: adjuvant 5-FU/cisplatin and chemoradiation with capecitabine
Q34488678Placebo-Controlled Trial to Determine the Effectiveness of a Urea/Lactic Acid–Based Topical Keratolytic Agent for Prevention of Capecitabine-Induced Hand-Foot Syndrome: North Central Cancer Treatment Group Study N05C5
Q35542484Postoperative Capecitabine with Concurrent Intensity-Modulated Radiotherapy or Three-Dimensional Conformal Radiotherapy for Patients with Stage II and III Rectal Cancer
Q44067905Potential of capecitabine as first-line therapy for metastatic breast cancer: dosing recommendations in patients with diminished renal function
Q58583964Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer
Q33620052Quality-of-life findings from a randomised phase-III study of XELOX vs FOLFOX-6 in metastatic colorectal cancer
Q44723860Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma
Q53374544Randomized phase III trial of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer: SALTO study by the Dutch Colorectal Cancer Group.
Q89208465Real-World Adverse Effects of Capecitabine Toxicity in an Elderly Population
Q46652612Redefining adjuvant chemotherapy in patients with stage III colon cancer: X-ACT trial
Q98213026Regulatory CDH4 genetic variants associate with risk to develop capecitabine-induced hand-foot syndrome
Q25257445Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study
Q47139930Reversible severe fatty liver induced by capecitabine: A case report
Q27021105Review of systemic therapies for locally advanced and metastatic rectal cancer
Q40751962Risk Factors Exacerbating Hand-Foot Skin Reaction Induced by Capecitabine plus Oxaliplatin with or without Bevacizumab Therapy.
Q35070531S-1-based chemotherapy versus capecitabine-based chemotherapy as first-line treatment for advanced gastric carcinoma: a meta-analysis.
Q55073748Safety data from the phase III Japanese ACHIEVE trial: part of an international, prospective, planned pooled analysis of six phase III trials comparing 3 versus 6 months of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer.
Q37781051Safety of capecitabine: a review
Q37337130Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers
Q44767638Short-time infusion of oxaliplatin (Eloxatin) in combination with capecitabine (Xeloda) in patients with advanced colorectal cancer
Q38216008Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?
Q36615421Side effects during chemotherapy predict tumour response in advanced colorectal cancer
Q99551807Significance of age-associated quality of life in patients with stage IV breast cancer who underwent endocrine therapy in Japan
Q36277429Supporting adherence to oral anticancer agents: clinical practice and clues to improve care provided by physicians, nurse practitioners, nurses and pharmacists
Q40030910Synchronous hepatic metastasis and metachronous Krukenberg tumor from advanced colon cancer. A case report with an unexpected disease-free survival
Q37345922Systemic and targeted therapy for advanced colon cancer
Q95806910Systemic chemotherapy with doxorubicin, cisplatin and capecitabine for metastatic hepatocellular carcinoma
Q37109507Systemic therapy for metastatic colorectal cancer: current questions
Q38059634Systemic treatment of gastrointestinal cancer in elderly patients
Q33916021Targeting cancers in the gastrointestinal tract: role of capecitabine
Q43435815The Medical Care Continuity (MCC) project. A pilot study of video-assisted home care within the eTEN European Community program. The Italian experience
Q36895084The effect of comorbidity on the use of adjuvant chemotherapy and type of regimen for curatively resected stage III colon cancer patients
Q38842633Therapeutic drug monitoring of 5-fluorouracil.
Q80510490Thymidylate synthase inhibitors
Q37653406Tolerability of Capecitabine Monotherapy in Metastatic Colorectal Cancer: A Real-World Study
Q36715266Tolerance to chemotherapy in elderly patients with cancer
Q37427386Toxic effects and their management: daily clinical challenges in the treatment of colorectal cancer
Q34577462Toxicity associated with capecitabine plus oxaliplatin in colorectal cancer before and after an institutional policy of capecitabine dose reduction
Q44457418Treatment of advanced colorectal carcinoma with oxaliplatin and capecitabine: a phase II trial
Q26781457Treatment of colorectal cancer in the elderly
Q43125193Unilateral hand-foot syndrome: an extraordinary side effect of capecitabine
Q49547512Up-regulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1.
Q35693336Update on adjuvant trials in the treatment of high-risk colorectal cancer
Q80080404[Hand-foot syndrome with capecitabine therapy]
Q82366772[Management of colorectal cancer of elderly patients]
Q79303377[Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer]

Search more.