Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier

scientific article published on September 1, 2003

Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1025789606885
P698PubMed publication ID14567628

P2093author name stringJie Shen
Devin F. Welty
Diane D. S. Tang-Liu
Stacy T. Cross
P2860cites workRelationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drugQ42496777
An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitolQ48301830
Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrierQ48436806
Characterization of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitroQ48464776
Regulation of vascular permeability in cell culture.Q52494322
Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the ratQ67754507
Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitroQ71152689
Studies on the permeability of the blood-retinal barrier. IV. Junctional complexes of the retinal vessels and their role in the permeability of the blood-retinal barrierQ72788727
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport propertiesQ73469399
Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion techniqueQ74332418
Diabetic retinopathyQ93910027
Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transportQ30321148
Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat.Q31849254
Retinitis pigmentosa: defined from a molecular point of viewQ33534644
Glucose transport in brain and retina: implications in the management and complications of diabetesQ33737742
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeabilityQ34057451
Ischemic maculopathy in patients with acquired immunodeficiency syndromeQ34434921
Permeability of the blood-brain barrier for atenolol studied by positron emission tomographyQ34543317
The blood-ocular barriersQ39800840
Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.Q40639360
Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assaysQ40712615
MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retinaQ40757936
Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayersQ41432245
Drug entry into the brainQ41729326
Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo modelsQ42041789
Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retinaQ42474219
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectbiotechnologyQ7108
pharmaceutical scienceQ7180763
endotheliumQ111140
pharmacologyQ128406
organic chemistryQ11351
molecular medicineQ3523816
P304page(s)1357-1363
P577publication date2003-09-01
P1433published inPharmaceutical ResearchQ7180737
P1476titleEvaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier
P478volume20

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cites work (P2860)
Q35091721Absorption and metabolism of xanthophylls
Q42484273Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier
Q46041576Efflux protein expression in human retinal pigment epithelium cell lines.
Q39923954Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids
Q26751148In Vitro Cell Models for Ophthalmic Drug Development Applications
Q37537014Inner blood-retinal barrier transporters: role of retinal drug delivery
Q39239140Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier
Q38063860Ocular Drug Delivery; Impact of in vitro Cell Culture Models
Q39140289Renal Drug Transporters and Drug Interactions
Q36197966Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis
Q59329173The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype
Q37741227The role of blood-ocular barrier transporters in retinal drug disposition: an overview

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