Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells

scientific article published on October 1, 2003

Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-4827(03)00286-6
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0014482703002866?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0014482703002866?httpAccept=text/xml
P698PubMed publication ID14499636

P2093author name stringChristian Sell
Hong Zhang
Henry Hoff
P2860cites workCancer ResearchQ326097
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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction proteinQ28116980
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)Q28139056
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cellsQ28202098
Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibitionQ33962150
Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculationQ34331333
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The IRS-1 signaling systemQ40682085
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulinQ40722638
C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP.Q40750201
Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cellsQ40831672
Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiationQ40989063
The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol proteaseQ41173254
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Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cellsQ42470095
The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitroQ42502766
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Association of insulin receptor substrate 3 with SH2 domain-containing proteins in rat adipocytesQ47922589
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPasesQ48014886
Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells.Q51080013
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.Q52828725
Calpain and caspase: can you tell the difference?, by Kevin K.W. WangQ58115473
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 functionQ73019421
Insulin-like growth factor I-mediated degradation of insulin receptor substrate-1 is inhibited by epidermal growth factor in prostate epithelial cellsQ73794088
Mechanism and role of growth arrest in programmed (apoptotic) death of prostatic cancer cells induced by thapsigarginQ73868526
Mitogen-independent phosphorylation of S6K1 and decreased ribosomal S6 phosphorylation in senescent human fibroblastsQ74172357
Thapsigargin analogues for targeting programmed death of androgen-independent prostate cancer cellsQ78181254
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)352-358
P577publication date2003-10-01
P1433published inExperimental Cell ResearchQ1524289
P1476titleDownregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells
P478volume289