Characterization of the Regulation of CD46 RNA Alternative Splicing.

scientific article published on 12 May 2016

Characterization of the Regulation of CD46 RNA Alternative Splicing. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M115.710350
P932PMC publication ID4933185
P698PubMed publication ID27226545

P50authorPhuong Thao LyQ89289766
Xavier RocaQ42177767
P2093author name stringEling Goh
Sze Jing Tang
Shufang Luo
Jia Xin Jessie Ho
P2860cites workActivation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotypeQ24293121
Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotypeQ24318004
Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicingQ24321295
The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sitesQ24337164
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicingQ24631683
Splicing regulation: from a parts list of regulatory elements to an integrated splicing codeQ24642620
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Mechanisms of alternative pre-messenger RNA splicingQ28131822
TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAsQ28213914
Context-dependent control of alternative splicing by RNA-binding proteinsQ28245737
Specific interactions between proteins implicated in splice site selection and regulated alternative splicingQ28257351
Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definitionQ28267920
Expansion of the eukaryotic proteome by alternative splicingQ29615083
Understanding alternative splicing: towards a cellular codeQ29615085
Listening to silence and understanding nonsense: exonic mutations that affect splicingQ29618493
Ligation of CD46 to CD40 inhibits CD40 signaling in B cellsQ30428085
An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancersQ33249150
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndromeQ33357218
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASFQ33374529
Polypyrimidine tract binding protein antagonizes exon definitionQ33558440
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cellsQ33570304
CD46-induced human Treg enhance B-cell responsesQ33796410
The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activationQ33809500
Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogeneQ33992355
A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarizationQ34102432
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcriptsQ34149373
Nuclear export and retention signals in the RS domain of SR proteinsQ34286089
Type 1 T regulatory cells.Q34448429
Regulation of alternative splicing by reversible protein phosphorylationQ34585110
Global impact of RNA polymerase II elongation inhibition on alternative splicing regulationQ34605595
Alternative splicing and evolution: diversification, exon definition and functionQ34618555
Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesionQ42445154
Autophagy induction by the pathogen receptor CD46.Q42461485
SFmap: a web server for motif analysis and prediction of splicing factor binding sitesQ42739011
Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b.Q42937991
Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein.Q43967291
Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activationQ44552994
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decayQ44734157
Selective suppression of IL-12 production by human herpesvirus 6.Q47800124
MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.Q50721021
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.Q51562160
How slow RNA polymerase II elongation favors alternative exon skipping.Q54355333
Functional defects of CD46-induced regulatory T cells to suppress airway inflammation in mite allergic asthma.Q54500409
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.Q54560552
Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicingQ57272510
Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicingQ61779875
Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complementQ71151732
Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domainsQ72332169
Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoaQ74449393
A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulationQ34775901
Human Splicing Finder: an online bioinformatics tool to predict splicing signalsQ34973311
Comprehensive splice-site analysis using comparative genomicsQ35013128
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosisQ35127765
Obstacles to cancer immunotherapy: expression of membrane complement regulatory proteins (mCRPs) in tumorsQ35197931
Pre-mRNA splicing in the absence of an SR protein RS domainQ35209029
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformationQ35736854
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neuronsQ35855671
A novel role for CD46 in wound repairQ35928410
The gene encoding the splicing factor SF2/ASF is a proto-oncogeneQ36129226
SRSF1-Regulated Alternative Splicing in Breast CancerQ36136216
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms.Q36481243
Identification of a new class of exonic splicing enhancers by in vivo selectionQ36567695
Functional association between promoter structure and transcript alternative splicing.Q36597450
PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiationQ36868085
A computational approach for genome-wide mapping of splicing factor binding sitesQ37213798
Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA.Q37285454
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degenerationQ37331431
CD46 plasticity and its inflammatory bias in multiple sclerosisQ37832444
Pick one, but be quick: 5' splice sites and the problems of too many choicesQ38076663
The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptorQ38354701
Regulation of alternative splicing through coupling with transcription and chromatin structureQ38512691
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomesQ38591386
Informational Suppression to Probe RNA:RNA Interactions in the Context of Ribonucleoproteins: U1 and 5' Splice-Site Base-PairingQ38787220
Noncanonical registers and base pairs in human 5' splice-site selectionQ38896235
Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complexQ39101565
HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transitionQ39124461
miRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3'UTR of CD46.Q39688863
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational controlQ39742308
Cooperative-binding and splicing-repressive properties of hnRNP A1.Q39814580
Nonsense-mediated mRNA decay (NMD) mechanismsQ40005465
Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherenceQ40819553
Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46.Q40846624
Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylationQ40875377
Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylationQ40902413
hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assemblyQ41226829
Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotidesQ42177704
P4510describes a project that usesImageQuantQ112270642
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectalternative mRNA splicing, via spliceosomeQ21114084
P304page(s)14311-14323
P577publication date2016-05-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of the Regulation of CD46 RNA Alternative Splicing
P478volume291

Reverse relations

cites work (P2860)
Q55247200Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch.
Q88101871Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells
Q90044328Broad regulation of gene isoform expression by Wnt signaling in cancer
Q52574294Complement and the Regulation of T Cell Responses.
Q47196269Complement as a regulator of adaptive immunity
Q92128538Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors
Q92020484Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature
Q41462498Non-random pairing of CD46 isoforms with skewing towards BC2 and C2 in activated and memory/effector T cells
Q45903443Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides.
Q89961850Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis

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