PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain

scientific article published on 20 December 2011

PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025704992
P356DOI10.1186/1744-8069-7-99
P932PMC publication ID3266216
P698PubMed publication ID22185613
P5875ResearchGate publication ID51903706

P2093author name stringYue Huang
Fernando Cervero
Mark H Pitcher
Naresh Kumar
Terence J Coderre
Todd C Sacktor
Andre Laferrière
Anne Haldane
Virginia Cornea
P2860cites workImplication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in miceQ44852820
Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy.Q45096018
Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat.Q45114795
Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitorQ48580760
Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primateQ48691205
Central nervous system plasticity in the tonic pain response to subcutaneous formalin injectionQ48838894
Lumbar catheterization of the subarachnoid space with a 32-gauge polyurethane catheter in the rat.Q50511751
Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex.Q51017555
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domainQ67734365
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicinQ68136348
Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in ratsQ71733172
Loose ligation of the rat sciatic nerve is accompanied by changes in the subcellular content of protein kinase C beta II and gamma in the spinal dorsal hornQ73978254
Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in ratsQ74589848
PKMzeta maintains spatial, instrumental, and classically conditioned long-term memoriesQ21090185
Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiationQ24561596
Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memoryQ28186778
Protein kinase Mzeta is necessary and sufficient for LTP maintenanceQ28210214
Ectopic discharge in Abeta afferents as a source of neuropathic painQ28236294
Storage of spatial information by the maintenance mechanism of LTPQ28260037
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgammaQ28512432
Neuronal plasticity: increasing the gain in painQ29615421
Quantitative assessment of tactile allodynia in the rat pawQ29617366
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaQ29620385
Central sensitization and LTP: do pain and memory share similar mechanisms?Q34277624
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.Q34554719
Protein kinase C modulation of NMDA currents: an important link for LTP inductionQ35337651
Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat.Q35658338
Long-term potentiation, protein kinase C, and glutamate receptorsQ36472925
Persistent postsurgical pain: risk factors and preventionQ36477806
Protein kinases as potential targets for the treatment of pathological painQ36646044
Transition from acute to chronic postsurgical pain: risk factors and protective factorsQ37464199
Central mechanisms of pathological painQ37800357
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant miceQ41719698
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.Q41740218
Cutaneous tactile allodynia associated with microvascular dysfunction in muscleQ41871962
Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.Q42279262
Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitizationQ42729374
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex.Q42787094
Role of the NKCC1 co-transporter in sensitization of spinal nociceptive neuronsQ42864529
Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neuronsQ43741458
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.Q44402813
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal ratsQ44755279
P4510describes a project that usesImageJQ1659584
P304page(s)99
P577publication date2011-12-20
P1433published inMolecular PainQ15766244
P1476titlePKMζ is essential for spinal plasticity underlying the maintenance of persistent pain
P478volume7

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cites work (P2860)
Q90737321A case report of sustained resolution of cancer pain by continuous perineural infusion of local anaesthetic
Q39327497BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state
Q92903865Blockade of BDNF signalling attenuates chronic visceral hypersensitivity in an IBS-like rat model
Q28083722Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain
Q37461552Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain.
Q35981182Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain
Q48324396How is chronic pain related to sympathetic dysfunction and autonomic dysreflexia following spinal cord injury?
Q38100425How to erase memory traces of pain and fear
Q39630405Involvement of Spinal PKMζ Expression and Phosphorylation in Remifentanil-Induced Long-Term Hyperalgesia in Rats
Q28710372Memory maintenance by PKMζ--an evolutionary perspective
Q91583648Memory: An Extended Definition
Q39466676PKM and the maintenance of memory
Q38867708PKMζ Is Not Required for Development of Postsurgical Pain
Q28646405PKMζ knockdown disrupts post-ischemic long-term potentiation via inhibiting postsynaptic expression of aminomethyl phosphonic acid receptors
Q47243078Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor
Q35649463Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
Q36118963Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury.
Q46337882Role of a novel nociceptor autocrine mechanism in chronic pain
Q64915987Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization.
Q96436022Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Q55662826Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons.
Q47590443Spinal activation of protein kinase C elicits phrenic motor facilitation.
Q36488893Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation
Q50051877Spinal protein kinase Mζ contributes to the maintenance of peripheral inflammation-primed persistent nociceptive sensitization after plantar incision
Q30391488Structural Models for the Design of PKMzeta Inhibitors with Neurobiological Indications
Q42717900The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain.
Q47159403The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor
Q42078588The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw.
Q36332325The pharmacology of nociceptor priming
Q37336074The thalamo-cortical complex network correlates of chronic pain
Q35126155Topical combinations to treat microvascular dysfunction of chronic postischemia pain
Q38083881ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
Q36173041Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model

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