An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting

scientific article published on 5 July 2016

An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M116.744326
P932PMC publication ID5000095
P698PubMed publication ID27382061

P50authorJohn F AtkinsQ38589745
Zoya IgnatovaQ88401015
P2093author name stringFrauke Adamla
Rico Schieweck
Paul Saffert
P2860cites workPolyalanine and polyserine frameshift products in Huntington's diseaseQ24656119
Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservationQ24682819
RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersQ26823908
Mechanisms and implications of programmed translational frameshiftingQ26852197
Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizymeQ28117992
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutationQ28246858
Stem-loop structure of Cocksfoot mottle virus RNA is indispensable for programmed -1 ribosomal frameshiftingQ28258312
Trinucleotide Repeat DisordersQ29038716
Expression levels influence ribosomal frameshifting at the tandem rare arginine codons AGG_AGG and AGA_AGA in Escherichia coliQ33855616
Amino acid runs in eukaryotic proteomes and disease associationsQ33897618
Hungry codons promote frameshifting in human mitochondrial ribosomesQ34092844
Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recodingQ34383861
Why base tautomerization does not cause errors in mRNA decoding on the ribosomeQ34489615
Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disordersQ34543709
Ribosomal frameshifting on MJD-1 transcripts with long CAG tractsQ34559976
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinaseQ34716802
Ribosome excursions during mRNA translocation mediate broad branching of frameshift pathwaysQ35132310
Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophyQ35694039
An mRNA sequence derived from the yeast EST3 gene stimulates programmed +1 translational frameshifting.Q35697496
Dynamic pathways of -1 translational frameshiftingQ35756018
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathwayQ36117201
Programmed translational -1 frameshifting on hexanucleotide motifs and the wobble properties of tRNAsQ36245899
Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 directionQ36401203
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshiftingQ36649698
RNA pseudoknots and the regulation of protein synthesisQ37217777
Protein mistranslation: friend or foe?Q38229416
Global and local depletion of ternary complex limits translational elongationQ41902966
Programmed -1 frameshifting by kinetic partitioning during impeded translocationQ42209633
Degeneracy of the genetic code and stability of the base pair at the second position of the anticodonQ43058973
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteinsQ44833524
A molecular pathogenesis for transcription factor associated poly-alanine tract expansionsQ45034215
Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtinQ45291544
Molecular architecture of CAG repeats in human disease related transcriptsQ45293998
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivoQ45294913
Nuclear targeting of mutant Huntingtin increases toxicityQ45298981
Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cellsQ48016847
A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: frameshifting without tRNA slippageQ48110364
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.Q48373564
A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshiftingQ48547537
Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.Q52734262
Cell Biology. Clogging information flow in ALS.Q52778504
Secondary structures and starvation-induced frameshiftingQ74032555
CAG tract of MJD-1 may be prone to frameshifts causing polyalanine accumulationQ74171904
Factors that influence selection of coding resumption sites in translational bypassing: minimal conventional peptidyl-tRNA:mRNA pairing can sufficeQ75224653
P433issue35
P407language of work or nameEnglishQ1860
P304page(s)18505-18513
P577publication date2016-07-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleAn Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting
P478volume291

Reverse relations

cites work (P2860)
Q46818543Regulation of mRNA Translation in Neurons-A Matter of Life and Death
Q46094384Rethinking Unconventional Translation in Neurodegeneration
Q60919583mRNA-Mediated Duplexes Play Dual Roles in the Regulation of Bidirectional Ribosomal Frameshifting

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