Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60.

scientific article published on February 2003

Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0042-6822(02)00035-1
P698PubMed publication ID12620793

P50authorHong JinQ92344280
Helen ZhouQ101225198
Jackie ZhaoQ117268298
Harry B. GreenbergQ55950186
George KembleQ90948387
P2093author name stringBin Lu
Chienhui Ma
Chin-fen Yang
P2860cites workA DNA transfection system for generation of influenza A virus from eight plasmidsQ29642855
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The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in childrenQ34467468
Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccinesQ36826849
Biased (A-->I) hypermutation of animal RNA virus genomesQ40611835
The attenuation phenotype conferred by the M gene of the influenza A/Ann Arbor/6/60 cold-adapted virus (H2N2) on the A/Korea/82 (H3N2) reassortant virus results from a gene constellation effectQ44150781
Extragenic suppression of temperature-sensitive mutations in RNA segment 8 by replacement of different rna segments with those of other influenza A virus prototype strainsQ45279570
Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized controlled trialQ45748324
Temperature sensitive mutants of influenza A virus generated by reverse genetics and clustered charged to alanine mutagenesisQ45764775
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Adaptation and Growth Characteristics of Influenza Virus at 25° CQ45808266
Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virusQ45858197
The impact of influenza epidemics on mortality: introducing a severity index.Q54731473
Influenza Immunization for ChildrenQ57031310
Sequence comparisons of A/AA/6/60 influenza viruses: mutations which may contribute to attenuationQ71529417
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Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adultsQ74128252
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)18-24
P577publication date2003-02-01
P1433published inVirologyQ7934867
P1476titleMultiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60.
P478volume306

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