Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal

scientific article published on 19 February 2003

Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M301137200
P698PubMed publication ID12594203

P2093author name stringLarry Gerace
Tinglu Guan
Gino Cingolani
Carolin Koerner
P2860cites workTransport between the cell nucleus and the cytoplasmQ22065411
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domainsQ24292247
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein exportQ24292285
Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structureQ24316296
RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complexQ24649249
Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear importQ24652021
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alphaQ27617932
Structure of importin-beta bound to the IBB domain of importin-alphaQ27618407
Structural view of the Ran-Importin beta interaction at 2.3 A resolutionQ27618579
RNA architecture dictates the conformations of a bound peptideQ27619503
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alphaQ27622027
Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear traffickingQ27625995
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin betaQ27640251
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alphaQ27764929
Raster3D: photorealistic molecular graphicsQ27860557
Further additions to MolScript version 1.4, including reading and contouring of electron-density mapsQ27860974
Nucleocytoplasmic transport: the soluble phaseQ28131723
Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and TrpQ28271872
Amino-aromatic interactions in proteinsQ28290046
Evolutionary specialization of the nuclear targeting apparatusQ28645371
A hot spot of binding energy in a hormone-receptor interfaceQ29547547
Unraveling hot spots in binding interfaces: progress and challengesQ29614463
Transport into and out of the nucleusQ29615611
Cation-pi interactions in structural biologyQ29617384
Aromatic-aromatic interaction: a mechanism of protein structure stabilizationQ29620587
Multiple diverse ligands binding at a single protein site: a matter of pre-existing populationsQ31034789
Folding and binding cascades: dynamic landscapes and population shiftsQ33876426
Principles of protein-protein recognitionQ33954341
Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import.Q34286042
Influence of cargo size on Ran and energy requirements for nuclear protein importQ36324496
The direction of transport through the nuclear pore can be invertedQ36428044
Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complexQ41075696
Nuclear import factors importin α and importin β undergo mutually induced conformational changes upon associationQ57973315
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)16216-16221
P577publication date2003-02-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleSynergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal
P478volume278