Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

scientific article published on 3 May 2016

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00415-016-8128-X
P698PubMed publication ID27142710

P50authorRalph P. MaguireQ47817589
P2093author name stringEva Havrdová
Anna Belova
Andrew Wright
Hideki Garren
Donald R Johns
Anne Tisserant
Alla Goloborodko
Erik Wallstroem
P2860cites workDiagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”Q22252938
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosisQ24681662
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging studyQ28290823
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skinQ33415491
CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytesQ36085387
Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells.Q44671613
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled studyQ44755697
Serum levels of IL-17A in patients with relapsing-remitting multiple sclerosis treated with interferon-β.Q45807781
Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trialQ46467386
Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trialQ46911236
Secukinumab in plaque psoriasis--results of two phase 3 trialsQ49167189
A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing-remitting or secondary progressive multiple sclerosisQ82763063
P433issue7
P304page(s)1287-1295
P577publication date2016-05-03
P1433published inJournal of NeurologyQ6295649
P1476titleActivity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study
P478volume263

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