Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor

scientific article published on 11 November 2002

Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M209906200
P698PubMed publication ID12429736

P2093author name stringDarcie D Seachrist
John H Nilson
Christine C Quirk
P2860cites workCloning and expression of the human p8, a nuclear protein with mitogenic activityQ22009095
Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domainQ24534173
Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcriptionQ24554519
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteinsQ24652745
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Basic local alignment search toolQ25938991
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
Differential display of eukaryotic messenger RNA by means of the polymerase chain reactionQ28131789
Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell typesQ28137623
HMGI/Y proteins: flexible regulators of transcription and chromatin structureQ28201754
Signaling and transcriptional mechanisms in pituitary developmentQ28209918
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoterQ28213723
Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)Q28255725
Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growthQ28257110
Transforming growth factor beta-1 enhances Smad transcriptional activity through activation of p8 gene expressionQ28367243
p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosisQ28587813
Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factorQ28854363
Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylationQ28910375
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogeneQ33757514
Signaling mechanisms in pituitary morphogenesis and cell fate determinationQ33796353
HMG-I/Y, a new c-Myc target gene and potential oncogeneQ33964722
Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cellsQ33966952
Molecular biology of HMGA proteins: hubs of nuclear functionQ34095287
An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturationQ34099931
Glycoprotein Hormones: Structure and FunctionQ34252688
RNA interference: listening to the sound of silenceQ34347832
Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair elementQ34612051
Tissue-specific gene expression in the pituitary: the glycoprotein hormone alpha-subunit gene is regulated by a gonadotrope-specific proteinQ36814887
Molecular biology of the pituitary gonadotropinsQ37809778
Helix-loop-helix proteins are present and differentially expressed in different cell lines from the anterior pituitaryQ38315510
A steroidogenic factor-1 binding site is required for activity of the luteinizing hormone beta subunit promoter in gonadotropes of transgenic miceQ38357998
Identification of differentially expressed mRNA species by an improved display technique (DDRT-PCR)Q40409962
Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA.Q40561043
A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic miceQ40809344
An NF-Y binding site is important for basal, but not gonadotropin-releasing hormone-stimulated, expression of the luteinizing hormone beta subunit geneQ40884561
LbetaT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to active A.Q40932385
Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.Q40955390
The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1.Q40979881
Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression.Q41034661
Amplification of the transcriptional signal mediated by the tandem cAMP response elements of the glycoprotein hormone alpha-subunit gene occurs through several distinct mechanismsQ41138275
Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell lineQ41209101
Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1.Q41214494
Different Composite Regulatory Elements Direct Expression of the Human α Subunit Gene to Pituitary and PlacentaQ41272576
Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic MiceQ41739669
In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse developmentQ42495320
Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit geneQ48037946
Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genesQ48068529
The PTX family of homeodomain transcription factors during pituitary developments.Q48403260
How many homeobox genes does it take to make a pituitary gland?Q48424256
The bicoid-related Pitx gene family in development.Q52180141
Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland.Q52214161
Cre-mediated recombination in the pituitary glandQ60719520
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1680-1685
P577publication date2002-11-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleEmbryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor
P478volume278

Reverse relations

cites work (P2860)
Q28587333A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing
Q35791015Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.
Q33787246Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function
Q42384708Developmentally regulated synthesis of p8, a stress-associated transcription cofactor, in diapause-destined embryos of Artemia franciscana
Q33397184Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches
Q50689689Expression and roles of As-NUPR1 protein from Artemia sinica during embryo development and in response to salinity stress.
Q38748843Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
Q34017922Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.
Q30421749NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo
Q24541470Regulation of apoptosis by the p8/prothymosin alpha complex
Q33581809Stress-inducible protein p8 is involved in several physiological and pathological processes
Q38306293The murine p8 gene promoter is activated by activating transcription factor 4 (ATF4) in the gonadotrope-derived LbetaT2 cell line
Q40389809The serotonin type 3A receptor facilitates luteinizing hormone release and LHbeta promoter activity in immortalized pituitary gonadotropes
Q35575317Transcriptional control during mammalian anterior pituitary development
Q28511147p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I
Q24797943p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth
Q39817713p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage

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