| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M211134200 |
| P698 | PubMed publication ID | 12424231 |
| P2093 | author name string | Philip J Moos | |
| Pamela Cassidy | |||
| Edmond Massuda | |||
| F A Fitzpatrick | |||
| Kornelia Edes | |||
| P2860 | cites work | Formation of a prostaglandin A2-glutathione conjugate in L1210 mouse leukemia cells | Q41819406 |
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| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hypoxia | Q105688 |
| P304 | page(s) | 745-750 | |
| P577 | publication date | 2002-11-06 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase | |
| P478 | volume | 278 |
| Q34477927 | 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator |
| Q39307607 | 3-Nitro-2H-chromenes as a new class of inhibitors against thioredoxin reductase and proliferation of cancer cells |
| Q41823335 | 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells |
| Q37577458 | APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase |
| Q33727905 | Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer |
| Q34931100 | Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology |
| Q24297014 | An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling |
| Q33326607 | Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells |
| Q39498322 | Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53. |
| Q40559822 | Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes |
| Q33804630 | Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling |
| Q42809254 | Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione |
| Q39812655 | Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast |
| Q37355468 | Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides. |
| Q35804051 | Formation and signaling actions of electrophilic lipids |
| Q36420004 | Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid. |
| Q43228786 | Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria |
| Q46875223 | Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species |
| Q37825687 | Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease |
| Q33526346 | JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1 |
| Q34933261 | Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration |
| Q39236149 | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. |
| Q28476153 | Purification of Reversibly Oxidized Proteins (PROP) Reveals a Redox Switch Controlling p38 MAP Kinase Activity |
| Q28571098 | Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine |
| Q40346993 | Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein tra |
| Q36140846 | Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. |
| Q37861632 | Redox modulation of p53: mechanisms and functional significance |
| Q33885097 | Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function |
| Q34820264 | Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium |
| Q36993984 | Selenium for the prevention of cutaneous melanoma |
| Q46106760 | Selenium variation induced oxidative stress regulates p53 dependent germ cell apoptosis: plausible involvement of HSP70-2. |
| Q37792840 | Selenium: a double-edged sword for defense and offence in cancer |
| Q50192080 | Selenoproteins and cardiovascular stress |
| Q47622822 | Selenoproteins in Tumorigenesis and Cancer Progression |
| Q37392209 | Selenoproteins that function in cancer prevention and promotion |
| Q35114481 | Signaling actions of electrophiles: anti-inflammatory therapeutic candidates |
| Q55347806 | TGA2 signaling in response to reactive electrophile species is not dependent on cysteine modification of TGA2. |
| Q33304452 | Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication |
| Q35462506 | The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways |
| Q47253881 | The A to Z of modulated cell patterning by mammalian thioredoxin reductases. |
| Q28397704 | The effects of chromium(VI) on the thioredoxin system: implications for redox regulation |
| Q28388959 | The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function |
| Q38828101 | The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion |
| Q24683703 | The organization and consequences of eicosanoid signaling |
| Q34274107 | The thioredoxin system—From science to clinic |
| Q41982836 | The yin and yang of nrf2-regulated selenoproteins in carcinogenesis |
| Q34601360 | Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha |
| Q36430099 | Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism |
| Q40299705 | Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells |
| Q39648281 | Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction |
| Q36447023 | Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis |
| Q37039957 | Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness |
| Q28389739 | Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling |
| Q24564266 | Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis |
| Q51342545 | Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker. |
| Q28080723 | TrxR1 as a potent regulator of the Nrf2-Keap1 response system |
| Q38311123 | Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium? |
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