Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

scientific article published on 30 October 2002

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M209548200
P8608Fatcat IDrelease_rhkiad2gmvacxcslmkfbnnceim
P698PubMed publication ID12411431
P5875ResearchGate publication ID11054380

P50authorJean-Philippe RichardQ39387707
Leonid V ChernomordikQ115262356
Kamran MelikovQ115262433
P2093author name stringBernard Lebleu
Corinne Ramos
Eric Vives
Birgit Verbeure
Mike J Gait
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)585-590
P577publication date2002-10-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleCell-penetrating peptides. A reevaluation of the mechanism of cellular uptake
P478volume278

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Q81131655Disulfide conjugation of peptides to oligonucleotides and their analogs
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Q34432312Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery
Q83357754Dynamics of transportan in bicelles is surface charge dependent
Q47761388Effect of Cell Permeable Peptide of c-Jun NH2-Terminal Kinase Inhibitor on the Attenuation of Renal Ischemia-Reperfusion Injury in Pigs
Q50218239Effect of a Flexible Linker on Recombinant Expression of Cell-Penetrating Peptide Fusion Proteins and Their Translocation into Fungal Cells.
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Q50612461Effect of crotamine, a cell-penetrating peptide, on blastocyst production and gene expression of in vitro fertilized bovine embryos
Q36837673Effective Delivery of Male Contraceptives Behind the Blood-Testis Barrier (BTB) - Lesson from Adjudin
Q51042734Effective capture of proteins inside living cells by antibodies indirectly linked to a novel cell-penetrating polymer-modified protein A derivative
Q43419167Effects of the TAT Peptide Orientation and Relative Location on the Protein Transduction Efficiency
Q34149828Efficient and targeted delivery of siRNA in vivo
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Q38300633Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide
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Q42256218Elevation of protein kinase Cα stimulates osteogenic differentiation of mesenchymal stem cells through the TAT-mediated protein transduction system
Q41998121Elucidating the function of penetratin and a static magnetic field in cellular uptake of magnetic nanoparticles.
Q88611552Emerging Methods and Design Principles for Cell-Penetrant Peptides
Q40199589Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retro-inverso Tat cell penetrating peptide.
Q38626954Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans
Q59286596Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1
Q37957323Engineered biological entities for drug delivery and gene therapy protein nanoparticles.
Q98612778Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue
Q24797478Enhanced cell-permeant Cre protein for site-specific recombination in cultured cells
Q38963387Enhanced cellular uptake of a TAT-conjugated peptide inhibitor targeting the polo-box domain of polo-like kinase 1.
Q34089281Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization
Q39965322Enhanced delivery efficiency of recombinant adenovirus into tumor and mesenchymal stem cells by a novel PTD.
Q53646238Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG.
Q48092003Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells
Q35087556Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides
Q45011121Enhancing membrane permeability by fatty acylation of oligoarginine peptides
Q39274701Enhancing the Cellular Delivery of Nanoparticles using Lipo-Oligoarginine Peptides
Q37043911Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides
Q34056922Enlarging the scope of cell-penetrating prenylated peptides to include farnesylated 'CAAX' box sequences and diverse cell types
Q40468131Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells.
Q42823027Evaluation of Cell-Penetrating Peptide/Adenovirus Particles for Transduction of CAR-Negative Cells
Q47801933Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor.
Q29048586Evaluation of the use of therapeutic peptides for cancer treatment
Q40181528Evidence for intercellular trafficking of VP22 in living cells
Q52551292Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons
Q42168186Evidence of protein transduction but not intercellular transport by proteins fused to HIV tat in retinal cell culture and in vivo
Q46516001Evidence that membrane transduction of oligoarginine does not require vesicle formation
Q30497908Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization.
Q52715623Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes
Q28480614Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase
Q34998244Exogenous and Cell Surface Glycosaminoglycans Alter DNA Delivery Efficiency of Arginine and Lysine Homopeptides in Distinctly Different Ways
Q37988482Exploring Transduction Mechanisms of Protein Transduction Domains (PTDs) in Living Cells Utilizing Single-Quantum Dot Tracking (SQT) Technology
Q33866011Exploring the cellular accumulation of metal complexes
Q39616924Expressed cell-penetrating peptides can induce a bystander effect, but passage through the secretory pathway reduces protein transduction activity.
Q36082666Exquisitely specific bisubstrate inhibitors of c-Src kinase.
Q41913898Factors controlling the efficiency of Tat-mediated plasmid DNA transfer
Q35111049Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12.
Q110651387Five Silkworm 30K Proteins Are Involved in the Cellular Immunity against Fungi
Q58564633Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins
Q92947788Fluorescent Tau-derived Peptide for Monitoring Microtubules in Living Cells
Q36900822Fluorogenic probe for constitutive cellular endocytosis
Q84044756Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses
Q36554270Free Energy of Translocating an Arginine-Rich Cell-Penetrating Peptide across a Lipid Bilayer Suggests Pore Formation
Q27318180Functional characterisation of the WW minimal domain for delivering therapeutic proteins by adenovirus dodecahedron
Q39381101Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies.
Q37302292Functional inclusion bodies produced in the yeast Pichia pastoris.
Q38928987Functional peptides for siRNA delivery
Q31137535Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells
Q61013237Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability
Q37772516Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting.
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Q34016744Gene knockdowns in adult animals: PPMOs and vivo-morpholinos
Q99403216General Method for Peptide Recognition in Water through Bioinspired Complementarity
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Q46786462Glycosphingolipid-facilitated membrane insertion and internalization of cobra cardiotoxin. The sulfatide.cardiotoxin complex structure in a membrane-like environment suggests a lipid-dependent cell-penetrating mechanism for membrane binding polypept
Q39973491Glycosylated cell-penetrating peptides and their conjugates to a proapoptotic peptide: preparation by click chemistry and cell viability studies.
Q30472806Gold nanoparticles delivery in mammalian live cells: a critical review
Q51420709Golden perspective: application of laser-generated gold nanoparticle conjugates in reproductive biology.
Q39706590Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis
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Q47583201Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.
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Q24564896HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
Q48797704Happy birthday cell penetrating peptides: Already 20 years
Q40644955Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells.
Q35084374Heparan sulfate proteoglycan as a plasma membrane carrier
Q39440362Hepatitis B virus envelope L protein-derived bio-nanocapsules: Mechanisms of cellular attachment and entry into human hepatic cells
Q33554640Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells
Q42807401High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression.
Q34533160High-glucose-induced endothelial cell injury is inhibited by a Peptide derived from human apolipoprotein E.
Q42813621Highly efficient intracellular drug delivery with a negatively charged hyperbranched polysulfonamine
Q33285497How to address CPP and AMP translocation? Methods to detect and quantify peptide internalization in vitro and in vivo (Review).
Q27355524How to unveil self-quenched fluorophores and subsequently map the subcellular distribution of exogenous peptides
Q45873436Human cytomegalovirus protein pp65: an efficient protein carrier system into human dendritic cells
Q34520408Human β-defensin 3 promotes NF-κB-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck
Q42359281Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED.
Q34004482Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides
Q33393157Identification and characterization of a novel cell-penetrating peptide
Q30564015Identification of a Novel Cell-Penetrating Peptide from Human Phosphatidate Phosphatase LpIN3
Q36010308Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity
Q43559547Imaging the cytosolic drug delivery mechanism of HDL-like nanoparticles.
Q58696260Immunogenicity of a Tripartite Cell Penetrating Peptide Containing a MUC1 Variable Number of Tandem Repeat (VNTR) and A T Helper Epitope
Q39751992Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells
Q46976778Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides
Q34021802Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors
Q49852449Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction
Q36972091Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.
Q37277330Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges
Q39605996In Vivo Anti-Tumor Effect of Expressing p14ARF-TAT Using a FGF2-Targeted Cationic Lipid Vector
Q34996432In vitro and ex vivo evaluation of smart infra-red fluorescent caspase-3 probes for molecular imaging of cardiovascular apoptosis
Q44090492Increased Hydrophobic Block Length of PTDMs Promotes Protein Internalization
Q64118404Induction of tumor-specific CTL responses using the C-terminal fragment of Viral protein R as cell penetrating peptide
Q28478188Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA
Q42143723Inhibition of Vaccinia virus entry by a broad spectrum antiviral peptide
Q44658031Inhibition of excitatory neuronal cell death by cell‐permeable calcineurin autoinhibitory peptide
Q24324220Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins
Q33513277Inhibition of platelet activation by peptide analogs of the beta(3)-intracellular domain of platelet integrin alpha(IIb)beta(3) conjugated to the cell-penetrating peptide Tat(48-60).
Q35031898Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells
Q38563691Insights into the molecular mechanisms of action of bioportides: a strategy to target protein-protein interactions
Q40477356Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells.
Q33577349Interaction between cell-penetrating peptides and acid-sensitive anionic oligopeptides as a model for the design of targeted drug carriers
Q42013682Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization
Q42239679Interference with RUNX1/ETO Leukemogenic Function by Cell-Penetrating Peptides Targeting the NHR2 Oligomerization Domain
Q92900087Internalization mechanisms of cell-penetrating peptides
Q45265202Internalization of Jembrana disease virus Tat: possible pathway and implication
Q24655939Internalization of cationic peptides: the road less (or more?) traveled
Q26795943Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies
Q26767093Intracellular Delivery of Proteins with Cell-Penetrating Peptides for Therapeutic Uses in Human Disease
Q39515403Intracellular Protein Target Detection by Quantum Dots Optimized for Live Cell Imaging
Q37291277Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy
Q42835108Intracellular delivery of antibodies using TAT fusion protein A
Q40560822Intracellular delivery of functional proteins via decoration with transporter peptides
Q37176400Intracellular delivery of nanoparticles via the HIV-1 tat peptide
Q33321966Intracellular delivery of peptides via association with ubiquitin or SUMO-1 coupled to protein transduction domains
Q45478176Intracellular route and biological activity of exogenously delivered Rep proteins from the adeno-associated virus type 2.
Q26740106Intracellular targeting with engineered proteins
Q37710990Intracellular transduction using cell-penetrating peptides
Q42094009Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility
Q38927932Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide
Q34185626Investigating the intercellular spreading properties of the foamy virus Gag protein
Q37490599Labeling proteins inside living cells using external fluorophores for microscopy
Q90375954Library screening of cell-penetrating peptide for BY-2 cells, leaves of Arabidopsis, tobacco, tomato, poplar, and rice callus
Q38363543Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.
Q42868352Lipo-oligoarginines as effective delivery vectors to promote cellular uptake
Q39470273Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration
Q37052581Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
Q55145552Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery.
Q36309720Macrocycles as protein-protein interaction inhibitors
Q36924383Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides
Q38823975Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization
Q49842808Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake.
Q39549246Matrix metalloproteinase-1 induces cleavage of exogenous alphaB-crystallin transduced by a cell-penetrating peptide
Q36503914Mechanism Matters: A Taxonomy of Cell Penetrating Peptides.
Q39834242Mechanism for HIV-1 Tat insertion into the endosome membrane
Q38385016Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
Q52890143Mechanism of antifungal activity of antimicrobial peptide APP, a cell-penetrating peptide derivative, against Candida albicans: intracellular DNA binding and cell cycle arrest
Q31048762Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.
Q40354335Mechanism of uptake of C105Y, a novel cell-penetrating peptide
Q21296784Mechanisms of cellular uptake of cell-penetrating peptides
Q37268062Mechanisms of peptide amphiphile internalization by SJSA-1 cells in vitro
Q47734666Mechanistic Study of the Uptake/Permeation of Cell-Penetrating Peptides Across a Caco-2 Monolayer and Their Stimulatory Effect on Epithelial Insulin Transport
Q42808621Mechanistic and functional studies of the interaction of a proline-rich antimicrobial peptide with mammalian cells.
Q36870151Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery
Q36553868Melittin-grafted HPMA-oligolysine based copolymers for gene delivery
Q36023033Membrane damage as first and DNA as the secondary target for anti-candidal activity of antimicrobial peptide P7 derived from cell-penetrating peptide ppTG20 against Candida albicans
Q35549408Membrane permeability commonly shared among arginine‐rich peptides
Q40369050Membrane surface-associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides
Q39986995Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
Q30881434Membrane translocation of penetratin and its derivatives in different cell lines
Q33347477Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: a comparative study with epithelial cell cultures
Q31078024Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)
Q38122609Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury
Q38369494Modifications of natural peptides for nanoparticle and drug design
Q42122403Modulation of muscle contraction by a cell-permeable peptide
Q33677435Molecular basis for nanoscopic membrane curvature generation from quantum mechanical models and synthetic transporter sequences
Q37649485Molecular basis for the autonomous promotion of cell proliferation by angiogenin
Q40064048Molecular basis of the internalization of bovine immunodeficiency virus Tat protein
Q37985658Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Q36055526Molecular mechanisms in the dramatic enhancement of HIV‐1 Tat transduction by cationic liposomes
Q35997331Monitoring the cytosolic entry of cell-penetrating peptides using a pH-sensitive fluorophore
Q44846478Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species
Q35568452Multifunctional gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation.
Q37415239Multifunctional prenylated peptides for live cell analysis
Q35155406Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions
Q39760981Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides.
Q30474384Multiscale observation of biological interactions of nanocarriers: from nano to macro
Q36692522Myristoyl-based transport of peptides into living cells
Q40037129N terminus of calpain 1 is a mitochondrial targeting sequence
Q38807254NIR-Cyanine Dye Linker: a Promising Candidate for Isochronic Fluorescence Imaging in Molecular Cancer Diagnostics and Therapy Monitoring
Q44922021NMR solution structure and position of transportan in neutral phospholipid bicelles.
Q81509545Nanobiology: particles slip cell security
Q42802733Nanoengineering of stimuli-responsive protein-based biomimetic protocells as versatile drug delivery tools
Q38165639Nanopreparations for organelle-specific delivery in cancer
Q37058812Nanovehicular intracellular delivery systems
Q40531370New transport peptides broaden the horizon of applications for peptidic pharmaceuticals.
Q42283138Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
Q38084736Noninvasive Insulin Delivery: the Great Potential of cell-penetrating Peptides
Q39429345Novel Cell‐Penetrating Peptides Based on α‐Aminoxy Acids
Q40429544Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules
Q37644875Novel miR-122 delivery system based on MS2 virus like particle surface displaying cell-penetrating peptide TAT for hepatocellular carcinoma
Q43232047Novel multifunctional polyethylene glycol-transactivating-transduction protein-modified liposomes cross the blood-spinal cord barrier after spinal cord injury
Q36512557Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells.
Q51421234Novel tubulin-targeted cell penetrating antimitotic octapeptide.
Q36120101Nuclear localization of HBD-1 in human keratinocytes
Q84758878OPA quantification of amino groups at the surface of Lipidic NanoCapsules (LNCs) for ligand coupling improvement
Q38097313Observing the translocation of a mitochondria-penetrating peptide with solid-state NMR
Q42811827Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape.
Q37564527Oligoarginine-PEG-lipid particles for gene delivery
Q53643889Oligonucleotides make sensible strides
Q37393524Oligopeptide-mediated gene transfer into mouse corneal endothelial cells: expression, design optimization, uptake mechanism and nuclear localization.
Q41879197On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptide
Q96345373Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells
Q37975835Oral biodrug delivery using cell-penetrating peptide
Q39377152PEP‐1‐heat shock protein 27 protects from neuronal damage in cells and in a Parkinson’s disease mouse model
Q79741695PNA Technology
Q36860956Passive water-lipid peptide translocators with conformational switches: from single-molecule probe to cellular assay
Q33644922Pathway for polyarginine entry into mammalian cells
Q28577193Pdx-1 or Pdx-1-VP16 protein transduction induces beta-cell gene expression in liver-stem WB cells
Q48678243Penetratin peptide potentiates endogenous calcium-activated chloride currents in Xenopus oocytes
Q57594290Penetratin tandemly linked to a CTL peptide induces anti-tumour T-cell responses via a cross-presentation pathway
Q40317625Penetratin-membrane association: W48/R52/W56 shield the peptide from the aqueous phase.
Q35080230Peptide and protein drug delivery to and into tumors: challenges and solutions
Q33754501Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides
Q59201770Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4+ Solid Tumors
Q88562771Peptide-Binding Nanoparticle Materials with Tailored Recognition sites for Basic Peptides
Q93138367Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases
Q37347451Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems
Q56889662Peptides as drug delivery vehicles across biological barriers
Q34489488Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity
Q26746968Peptides for nucleic acid delivery
Q38027858Peptides for specific intracellular delivery and targeting of nanoparticles: implications for developing nanoparticle-mediated drug delivery
Q38243361Peptides used in the delivery of small noncoding RNA.
Q48009486Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration
Q57360742Photo-acceleration of protein release from endosome in the protein transduction system
Q47602614Photochemically enhanced cellular delivery of cell penetrating peptide-PNA conjugates
Q40049879Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells.
Q42202499Plasma membrane translocation of a protein needle based on a triple-stranded β-helix motif
Q44563746Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain
Q91975707Polyamide Backbone Modified Cell Targeting and Penetrating Peptides in Cancer Detection and Treatment
Q36004826Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing
Q37191389Polymeric linear Peptide chimeric vaccine-induced antimalaria immunity is associated with enhanced in vitro antigen loading
Q50518471Potent enhancement of GFP uptake into HT‐29 cells and rat skin permeation by coincubation with tat peptide
Q28479013Prediction of Cell Penetrating Peptides by Support Vector Machines
Q53723317Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods.
Q38885454Preparation of cell-permeable Cre recombinase by expressed protein ligation
Q91891978Prevention of quality decline and delivery of siRNA using exogenous TCTP translocation across the zona pellucida in mouse oocytes
Q38785368Progress in Research and Application of HIV-1 TAT-Derived Cell-Penetrating Peptide
Q50436669Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer's Disease
Q38205210Pros and cons of phospholipid asymmetry in erythrocytes
Q30410528Protein Structure Determination by Solid-State NMR
Q35345000Protein delivery using engineered virus-like particles
Q35136309Protein transduction domains: are they delivering?
Q45343688RETRACTED ARTICLE: Cell-specific delivery of messenger RNA and microRNA by recombinant MS2 virus-like particles carrying cell-penetrating peptide
Q34991955Rational design of a biomimetic cell penetrating peptide library
Q46637666Re-evaluating the role of strongly charged sequences in amphipathic cell-penetrating peptides: a fluorescence study using Pep-1.
Q43918861Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission
Q27487857Recent Developments in Peptide-Based Nucleic Acid Delivery
Q36316659Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo
Q40603207Receptor/transporter-independent targeting of functional peptides across the plasma membrane
Q41008655Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein
Q42176571Reducible, dibromomaleimide-linked polymers for gene delivery
Q34022618Reversible sheet-turn conformational change of a cell-penetrating peptide in lipid bilayers studied by solid-state NMR
Q44738584RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing
Q46008642Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication.
Q37297026Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR.
Q92211557SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Q33871187Scorpion venom components that affect ion-channels function
Q33938342Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery
Q47244197Secondary structure of cell-penetrating peptides during interaction with fungal cells
Q41957814Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells
Q37430304Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials
Q33713342Selective enhancement of the uptake and bioactivity of a TAT-conjugated peptide inhibitor of glycogen synthase kinase-3.
Q38610657Self-aggregation propensity of the Tat peptide revealed by UV-Vis, NMR and MD analyses.
Q37237907Self-assembled Tat nanofibers as effective drug carrier and transporter.
Q40254465Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery
Q84137177Self‐Activation in De Novo Designed Mimics of Cell‐Penetrating Peptides
Q35705907Sensing pH via p-cyanophenylalanine fluorescence: Application to determine peptide pKa and membrane penetration kinetics
Q88472505Sequence-Selective Recognition of Peptides in Aqueous Solution: A Supramolecular Approach through Micellar Imprinting
Q38729047Short polyhistidine peptides penetrate effectively into Nicotiana tabacum-cultured cells and Saccharomyces cerevisiae cells
Q47117237Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide
Q90334868Silk Fibroin as a Functional Biomaterial for Drug and Gene Delivery
Q42595034Silk-Based Gene Carriers with Cell Membrane Destabilizing Peptides
Q37714025Silk-based delivery systems of bioactive molecules.
Q30541727Single quantum dot tracking reveals that an individual multivalent HIV-1 Tat protein transduction domain can activate machinery for lateral transport and endocytosis
Q55266626Single quantum dot tracking reveals the impact of nanoparticle surface on intracellular state.
Q44472217Site-specific conjugation of HIV-1 tat peptides to IgG: a potential route to construct radioimmunoconjugates for targeting intracellular and nuclear epitopes in cancer
Q36436522Sizing the protein translocation pathway of colicin Ia channels
Q42809505Sono-assembly of highly biocompatible polysaccharide capsules for hydrophobic drug delivery
Q82324613Splice Redirection as a Convenient Assay to Monitor CPP–ON Efficiency and Mechanism
Q47762139Spontaneous Membrane Translocating Peptides: The Role of Leucine-Arginine Consensus Motifs
Q46697816Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties.
Q51769861Stable and sensitive probes for lysosomes: cell-penetrating fluorescent calix[4]arenes accumulate in acidic vesicles
Q39347424Structural Effects and Lipid Membrane Interactions of the pH-Responsive GALA Peptide with Fatty Acid Acylation
Q27300105Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: identification of an RGFRRR motif governing fungal cell entry
Q33827462Structure and dynamics of cationic membrane peptides and proteins: insights from solid-state NMR.
Q39315664Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein
Q44463875Studies on the internalization mechanism of cationic cell-penetrating peptides.
Q39750541Study on the intracellular fate of Tat peptide-conjugated quantum dots by spectroscopic investigation
Q59662712Studying the uptake of cell-penetrating peptides
Q38289633Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells
Q30489569Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles.
Q51362699Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine
Q42269919Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides
Q81584715Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains
Q83417203Synthesis of N-methylated cyclic peptides
Q24793327Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides
Q39373677Synthetic Nucleic Acid Analogues in Gene Therapy: An Update for Peptide-Oligonucleotide Conjugates
Q34545352Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers
Q39761178Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
Q39316870TAT-CC fusion protein depresses the oncogenicity of BCR-ABL in vitro and in vivo through interrupting its oligomerization
Q39850094TAT-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression
Q35818922TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.
Q34267418Target discovery
Q58566968Targeted Intracellular Delivery of Antibodies: The State of the Art
Q39116826Targeted delivery of a phosphopeptide prodrug inhibits the proliferation of a human glioma cell line
Q37682695Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells
Q73556234Targeted drug delivery systems for the intracellular delivery of macromolecular drugs
Q61444841Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14
Q35057544Targeted intracellular delivery of proteins with spatial and temporal control
Q33865968Targeting a ruthenium complex to the nucleus with short peptides
Q37368323Targeting anti-HIV drugs to the CNS.
Q37811739Targeting antibodies to the cytoplasm
Q38017804Targeting drugs to mitochondria
Q35826370Targeting plasmid-encoded proteins to the antigen presentation pathways
Q44624372Targeting proteins to mitochondria using TAT.
Q26799461Targeting the Eph System with Peptides and Peptide Conjugates
Q38974209Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy.
Q40027318Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.
Q34054988Tat-Mediated Peptide Intervention in Analgesia and Anesthesia.
Q46934430Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells
Q41849682Taurine Boosts Cellular Uptake of Small D-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly
Q40184296Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells.
Q35211115Tempo-spatially resolved cellular dynamics of human immunodeficiency virus transacting activator of transcription (Tat) peptide-modified nanocargos in living cells
Q38552370The Antimicrobial and Antiviral Applications of Cell-Penetrating Peptides.
Q83259815The Effects of the 4‐(4‐Methylpiperazine)phenyl Group on Nucleosides and Oligonucleotides: Cellular Delivery, Detection, and Stability
Q40478564The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction.
Q48761244The Pseudomonas aeruginosa exotoxin A translocation domain facilitates the routing of CPP–protein cargos to the cytosol of eukaryotic cells
Q40666814The Relation Between Thermodynamic and Structural Properties and Cellular Uptake of Peptides Containing Tryptophan and Arginine.
Q47743746The Role of Hydrophobicity in the Cellular Uptake of Negatively Charged Macromolecules.
Q92825203The Utilization of Cell-Penetrating Peptides in the Intracellular Delivery of Viral Nanoparticles
Q30159968The anti-angiogenic peptide anginex disrupts the cell membrane
Q45869894The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes
Q39544225The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH
Q57187330The cell-penetrating peptide TAT(48-60) induces a non-lamellar phase in DMPC membranes
Q39395281The cell-penetrating peptide domain from human heparin-binding epidermal growth factor-like growth factor (HB-EGF) has anti-inflammatory activity in vitro and in vivo
Q35950928The design and exogenous delivery of siRNA for post-transcriptional gene silencing.
Q37047226The design of guanidinium-rich transporters and their internalization mechanisms.
Q49627191The design of peptide-grafted graphene oxide targeting the actin cytoskeleton for efficient cancer therapy.
Q49611544The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.
Q46236828The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine
Q34277312The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate
Q35562110The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding
Q88394411The mechanism of lauric acid-modified protein nanocapsules escape from intercellular trafficking vesicles and its implication for drug delivery
Q36270676The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers.
Q33937098The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function
Q44301552The signal peptide NPFSD fused to ricin A chain enhances cell uptake and cytotoxicity in Candida albicans
Q40532537The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells
Q36695464The taming of the cell penetrating domain of the HIV Tat: myths and realities
Q35969026The use of cell-penetrating peptides for drug delivery
Q33268306The use of fullerene substituted phenylalanine amino acid as a passport for peptides through cell membranes
Q39541679The vimentin-tubulin binding site peptide (Vim-TBS.58-81) crosses the plasma membrane and enters the nuclei of human glioma cells
Q38104407Therapeutic potential of cell-penetrating peptides.
Q43842753Thermodynamics of Lipid Interactions with Cell-Penetrating Peptides
Q36911058Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8.
Q45876050Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity
Q36409033Transactivating transcriptional activator-mediated drug delivery
Q34311057Transactivating-transduction protein-polyethylene glycol modified liposomes traverse the blood-spinal cord and blood-brain barriers
Q53432656Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice
Q46750570Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult
Q50572161Transduction of cell-penetrating peptides into induced pluripotent stem cells.
Q42807094Transduction of peptides and proteins into live cells by cell penetrating peptides
Q33496608Transduction of the MPG-tagged fusion protein into mammalian cells and oocytes depends on amiloride-sensitive endocytic pathway
Q42781312Transfer of arginine into lipid bilayers is nonadditive.
Q35939416Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells.
Q33510861Translocation and endocytosis for cell-penetrating peptide internalization
Q35345277Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions
Q44597076Translocation of cell penetrating peptides on Chlamydomonas reinhardtii
Q46359263Translocation of cell-penetrating peptides into Candida fungal pathogens
Q34419039Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission
Q37530890Transport molecules using reverse sequence HIV-Tat polypeptides: not just any old Tat? (WO200808225).
Q92434851Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization
Q24796110Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide
Q40461207Trileucine residues in a ligand-CPP-based siRNA delivery platform improve endosomal escape of siRNA.
Q33569121Tumor imaging by means of proteolytic activation of cell-penetrating peptides
Q37230918Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics
Q39290246Tyroserleutide-based gene vector for suppressing VEGF expression in cancer therapy
Q28511917Unique membrane interaction mode of group IIF phospholipase A2
Q50021294Uptake and intracellular fate of cholera toxin subunit b-modified mesoporous silica nanoparticle-supported lipid bilayers (aka protocells) in motoneurons
Q30728924Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells
Q51361449Use of quantum dots for live cell imaging
Q50776745VP22 enhances antibody responses from DNA vaccines but not by intercellular spread
Q38872440Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells
Q37657525Various drug delivery approaches to the central nervous system
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