Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation

scientific article published on 15 June 2016

Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00813-16
P932PMC publication ID4988161
P698PubMed publication ID27307564

P50authorJ Pedro SimasQ42871822
Franceline JuillardQ83896766
Colin E. McVeyQ38320247
P2093author name stringMin Tan
Shijun Li
Kenneth M Kaye
Sofia A Cerqueira
P2860cites workTermination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligaseQ24309461
Building and remodelling Cullin-RING E3 ubiquitin ligasesQ27027816
Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferationQ27324746
A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA ProteinsQ27680409
Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANAQ27680411
Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral LatencyQ27680412
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexQ29041391
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cellsQ38325239
Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosomeQ39592358
ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replicationQ40094006
Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis.Q40139467
Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigenQ40169138
Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteinesQ40485825
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradationQ40485830
Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infectionQ40975071
K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.Q42812963
ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latency.Q47360085
KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistenceQ60178445
Glucocorticoids inhibit E-selectin expression by targeting NF-kappaB and not ATF/c-JunQ60633023
Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivoQ67970625
Murine gammaherpesvirus 68: a model for the study of gammaherpesvirus pathogenesisQ77148150
The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assemblyQ33321224
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complexQ33489621
Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency.Q33802415
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.Q33838228
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
In vivo imaging of murid herpesvirus-4 infectionQ33910580
Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genomeQ33966678
Identification of properties of the Kaposi's sarcoma-associated herpesvirus latent origin of replication that are essential for the efficient establishment and maintenance of intact plasmidsQ34057984
Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistenceQ34060663
APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse modelQ34352429
Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In VivoQ34411851
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistenceQ34553975
Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomesQ34554716
Epstein-Barr virus: exploiting the immune systemQ34572150
Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus LymphoproliferationQ34945490
Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replicationQ34977295
The Internal Kaposi's Sarcoma-Associated Herpesvirus LANA Regions Exert a Critical Role on Episome PersistenceQ35140238
Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytesQ35149225
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65Q35192868
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferaseQ35340408
The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNAQ35669267
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-MycQ36099076
Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistenceQ36363318
Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cellsQ36367286
Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cellsQ36371017
The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latencyQ36524534
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.Q36676548
SOCS proteins, cytokine signalling and immune regulationQ36831668
Mechanisms and function of substrate recruitment by F-box proteins.Q37307464
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)—an updateQ38114627
New insights into ubiquitin E3 ligase mechanismQ38201970
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)7667-7683
P577publication date2016-06-15
P1433published inJournal of VirologyQ1251128
P1476titleLatency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation
P478volume90

Reverse relations

Q40041231Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.cites workP2860

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