Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway

scientific article published on September 2002

Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022058381
P356DOI10.1038/SJ.CDD.4401062
P698PubMed publication ID12181741
P5875ResearchGate publication ID11205131

P2093author name stringBetticher DC
Schneider E
Borner MM
Pirnia F
P2860cites workOrdering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent mannerQ22008727
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9Q22009407
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosisQ24307362
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosisQ24316760
Mammalian caspases: structure, activation, substrates, and functions during apoptosisQ28139429
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADQ28258328
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerizationQ28275527
IAP family proteins--suppressors of apoptosisQ28297514
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesQ28506930
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosisQ28588677
Target protease specificity of the viral serpin CrmA. Analysis of five caspasesQ28640190
Caspases: enemies withinQ29547315
Mitochondria and apoptosisQ29547905
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosisQ29614983
Caspases: killer proteasesQ29616315
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.Q32061783
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistanceQ33182147
Molecular effects of paclitaxel: myths and reality (a critical review).Q33725219
p53 and chemosensitivity.Q33779334
Biochemical pathways of caspase activation during apoptosisQ33804316
Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cellsQ33844249
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytesQ33888184
Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapyQ36375843
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugsQ36401199
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)Q36774959
Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.Q39777499
Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8.Q40858469
The CD95/CD95 ligand system is not the major effector in anticancer drug-mediated apoptosisQ40961120
Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatinQ41202524
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspasesQ42657216
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.Q51091938
Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53.Q54036312
Adriamycin-induced DNA adducts inhibit the DNA interactions of transcription factors and RNA polymerase.Q54592064
Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic AcidQ57243601
Apaf-1 is a transcriptional target for E2F and p53Q57274134
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2Q57338694
Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cellsQ57384660
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosisQ73073993
Inhibition of fas death signals by FLIPsQ77485563
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)905-914
P577publication date2002-09-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleMitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway
P478volume9

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