Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction

scientific article published on 20 July 2015

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/HYPERTENSIONAHA.115.05627
P932PMC publication ID4685692
P698PubMed publication ID26195478

P2093author name stringJiang Xu
Nour-Eddine Rhaleb
Oscar A Carretero
Xiao-Ping Yang
Edward L Peterson
Branislava Janic
Hongmei Peng
Nadia Rhaleb
Zeyd Sarwar
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Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heartQ30471805
IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cellsQ31763724
Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertensionQ33764751
Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblastsQ34020430
Cardiac mast cells: the centrepiece in adverse myocardial remodellingQ34410300
Biological activity of IL-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptorQ34412392
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationQ35083309
Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heartQ35103548
CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosisQ35159918
Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction.Q35942679
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The cardiac fibroblast: therapeutic target in myocardial remodeling and failureQ36094597
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The relationship between myocardial extracellular matrix remodeling and ventricular functionQ36578692
Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responsesQ36591648
Immunological basis of systemic sclerosisQ36599181
Differential release of mast cell mediators and the pathogenesis of inflammationQ36819882
'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activationQ38106128
STAT6 and lung inflammationQ38177817
Force generation among cells in the relaxing heartQ39606513
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J miceQ40344427
Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1.Q40664842
Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivoQ40883930
Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cellsQ41860961
Interleukin 4 is localized to and released by human mast cellsQ41931345
Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergyQ42062005
Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophyQ42097897
Evidence for a role of mast cells in the evolution to congestive heart failureQ42944600
Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitisQ43997200
Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cellsQ44185531
IL-4-dependent up-regulation of IL-4 receptor expression in murine T and B cellsQ44341556
Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.Q44400944
Nutrient intake and serum cytokine pattern in elderly people with heart failureQ44644383
Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart.Q46034399
Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathwayQ46484361
Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin‐4: Analysis of the functional collagen promoter sequencesQ54744477
Diastolic Heart Failure — No Time to RelaxQ57073290
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophoresQ59052484
The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegalyQ68428980
The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell responseQ77373441
Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cellsQ77862157
Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repairQ79074374
Cardiac mast cells: implications for heart failureQ79915077
Differential gene expression in response to transforming growth factor-beta1 by fetal and postnatal dermal fibroblastsQ79920047
[Interleukin-4 and cardiac fibrosis in patients with heart failure]Q80702966
A pro-fibrotic role for interleukin-4 in cardiac pressure overloadQ83857166
Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodelingQ83877575
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)582-589
P577publication date2015-07-20
P1433published inHypertensionQ5958695
P1476titleProfibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction
P478volume66

Reverse relations

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Q90233203The Non-Fibrillar Side of Fibrosis: Contribution of the Basement Membrane, Proteoglycans, and Glycoproteins to Myocardial Fibrosis

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