Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.

scientific article

Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. is …
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scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00166.2001
P698PubMed publication ID12055104

P2093author name stringDavid A Brenner
Christian Jobin
Anthony M Manning
Maria P Russo
Brydon L Bennett
P2860cites workThe kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayQ22009096
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NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Q24319941
Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expressionQ41103827
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell typesQ41159609
Fas and other cell death signaling pathwaysQ41508135
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor IQ42015911
Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells.Q43552257
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Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.Q52542561
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Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseQ24522867
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunitQ24554482
Activation of IkappaB kinase beta by protein kinase C isoformsQ24554525
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaQ24681806
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-betaQ28139163
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activationQ28140522
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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activationQ28252726
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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathwayQ28302102
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1Q28302936
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NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseasesQ34015898
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activationQ35156450
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1Q36004058
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?Q36070075
Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40.Q36375765
NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic jointQ36803920
The CD95 (APO-1/Fas) receptor activates NF-kappaB independently of its cytotoxic functionQ38359122
Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cellsQ40838088
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmentiQ40866170
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinaseQ40954925
NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen speciesQ40973149
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.Q41062073
Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/streQ41087172
P433issue1
P921main subjectNF-κBQ411114
IkappaB kinase complexQ14908207
TNFQ18032037
P304page(s)C347-57
P577publication date2002-07-01
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleDifferential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
P478volume283