The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex

scientific article

The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M201884200
P698PubMed publication ID11986318

P2093author name stringM Lienhard Schmitz
Thomas G Hofmann
Andreas Möller
Dimitry Spitkovsky
Steffen P Hehner
P2860cites workIncreased tumorigenicity of human keratinocytes harboring human papillomavirus type 16 is associated with resistance to endogenous tumor necrosis factor-alpha-mediated growth limitationQ41487518
Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma proteinQ42804946
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activityQ50320367
Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins.Q52863553
Role of NF-κB in p53-mediated programmed cell deathQ57248006
Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivationQ22010674
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesisQ22253275
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsQ22253968
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complexQ24554281
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityQ24599944
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoproteinQ24676090
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaQ24681806
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesisQ28143403
pEF-BOS, a powerful mammalian expression vectorQ29547606
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene productQ29618372
PKN binds and phosphorylates human papillomavirus E6 oncoproteinQ30870479
Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107.Q33292294
Inhibition of Bak-induced apoptosis by HPV-18 E6.Q33292381
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivationQ33708904
Regulation of inducible gene expression by the transcription factor NF-kappaB.Q33736018
Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytesQ33839638
The IKK complex: an integrator of all signals that activate NF-kappaB?Q33877083
The Rb/E2F pathway and cancerQ34189004
NF-kappaB and cell-cycle regulation: the cyclin connectionQ34225148
Increased p50/p50 NF-kappaB activation in human papillomavirus type 6- or type 11-induced laryngeal papilloma tissueQ34329556
NF-kappaB signaling pathways in mammalian and insect innate immunityQ34373155
Immune evasion in human papillomavirus-associated cervical cancerQ34570129
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?Q36070075
Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130Q36388622
Functional oligomerization of purified human papillomavirus types 16 and 6b E7 proteins expressed in Escherichia coliQ36742884
A functional NF-kappaB binding site in the human papillomavirus type 16 long control regionQ38310876
Allosteric activation of acid alpha-glucosidase by the human papillomavirus E7 proteinQ38313989
The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.Q38354882
Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3Q39455066
Mechanism of inactivation of NF-kappa B by a viral homologue of I kappa b alpha. Signal-induced release of i kappa b alpha results in binding of the viral homologue to NF-kappa B.Q40616876
Human papillomavirus type 16 E6-enhanced susceptibility to apoptosis induced by TNF in A2780 human ovarian cancer cell lineQ40749297
Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cellsQ40786994
JNK2 and IKKbeta are required for activating the innate response to viral infectionQ40907787
Regulation of early gene expression of human papillomavirus type 16 by inflammatory cytokinesQ41476955
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P1104number of pages7
P304page(s)25576-25582
P577publication date2002-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex
P478volume277

Reverse relations

cites work (P2860)
Q39996005A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression.
Q34156179A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosis
Q35488924Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Q58779438Constitutive activation and overexpression of NF-κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis
Q57996111Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions
Q41837402Deregulation of the miRNAs expression in cervical cancer: human papillomavirus implications
Q104495217Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens
Q52764289Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers.
Q40260839Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes
Q42468679HPV-18 confers resistance to TNF-alpha in organotypic cultures of human keratinocytes.
Q60916954HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS
Q42218400HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis
Q40475356High levels of p105 (NFKB1) and p100 (NFKB2) proteins in HPV16-transformed keratinocytes: role of E6 and E7 oncoproteins.
Q28084802High-risk human papillomavirus targets crossroads in immune signaling
Q34743768Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response
Q36305948Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers
Q37315925Human papillomavirus and molecular considerations for cancer risk
Q33851664Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes
Q36216805Human papillomavirus genotypes in penile cancers from Japanese patients and HPV-induced NF-κB activation
Q39445934Human papillomavirus infection induces NF-κB activation in cervical cancer: A comparison with penile cancer
Q35787928Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization
Q40430288Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis
Q36827288Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification
Q42030463Identification of key amino acid residues that determine the ability of high risk HPV16-E7 to dysregulate major histocompatibility complex class I expression.
Q40543156Inhibition of nuclear factor kappaB activity by viral interferon regulatory factor 3 of Kaposi's sarcoma-associated herpesvirus.
Q37748135Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms
Q39003287Manipulation of the innate immune response by human papillomaviruses
Q40361594Mechanism for removal of tumor necrosis factor receptor 1 from the cell surface by the adenovirus RIDalpha/beta complex.
Q27002467Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection
Q39083904Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signaling
Q34309882Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus
Q28709497Modulation of NF-κB signalling by microbial pathogens
Q54651730Molecular cloning of IKKβ from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection.
Q38343954NF-κ B-dependent upregulation of ICAM-1 by HPV16-E6/E7 facilitates NK cell/target cell interaction.
Q24292906NF-κB signalling is attenuated by the E7 protein from cutaneous human papillomaviruses
Q34563758NF-κB-induced KIAA1199 promotes survival through EGFR signalling
Q42411008NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity
Q27487296Negative regulation of cytoplasmic RNA-mediated antiviral signaling
Q37316158Oncogenic activities of human papillomaviruses
Q55049874Oxidative stress in female cancers.
Q90399211Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation
Q36217010Relationship among human papillomavirus infection, p16(INK4a), p53 and NF-κB activation in penile cancer from northern Thailand
Q37002546Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional Profiling of E7-Expressing Cells
Q44269684Role of human papillomavirus infection in carcinogenesis of oral squamous cell carcinoma with evidences of prognostic association
Q37192229Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB.
Q98881813Structural and functional impacts of E5 genetic variants of human papillomavirus type 31
Q64084618The Double-Edged Sword-How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
Q57218500The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma
Q40444191The Interaction Between Human Papillomaviruses and the Stromal Microenvironment
Q90270888The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections
Q38428005The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma-molecular basis and predicting favorable outcome
Q40645798The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death
Q41055909The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes
Q39000409The human papillomavirus E7 oncoprotein as a regulator of transcription
Q35245080The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation.
Q37198662The papillomavirus E7 proteins
Q54707844Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression.
Q47775964Typing of human papillomavirus in Zimbabwean patients with invasive cancer of the uterine cervix
Q44092048Upregulation of nuclear factor-kappaB (NF-kappaB) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus or disease outcome in cervical cancer
Q28507062WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
Q39127526Zinc finger A20 and NF-κB correlate with high-risk human papillomavirus of squamous cell carcinoma patients