Chronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms

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Chronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms is …
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scholarly articleQ13442814

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P356DOI10.1046/J.1471-4159.2001.00664.X
P698PubMed publication ID11739624
P5875ResearchGate publication ID227772566

P2093author name stringOlsen RW
Ali NJ
P2860cites workTwo invariant tryptophans on the alpha1 subunit define domains necessary for GABA(A) receptor assemblyQ41689630
Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor alpha 1 subunit protein in rat cerebellar granule cells.Q41827131
Flunitrazepam rapidly reduces GABA(A) receptor subunit protein expression via a protein kinase C-dependent mechanism.Q42183475
Decreased GABAA receptor subunit mRNA concentrations following chronic lorazepam administrationQ42712513
Chronic zolpidem treatment alters GABA(A) receptor mRNA levels in the rat cortexQ48681471
Activation of protein kinase C induces gamma-aminobutyric acid type A receptor internalization in Xenopus oocytes.Q50741465
Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain.Q51744490
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivityQ51848031
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeletonQ22008682
beta-Arrestin: a protein that regulates beta-adrenergic receptor functionQ24305145
The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapseQ24643028
The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kineticsQ24672913
Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinaseQ28140825
Intracellular trafficking of GABA(A) receptorsQ33875647
The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptorsQ34084360
Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidences for a compensatory mechanism triggered by receptor loss.Q37387340
Genetic analysis of beta-adrenergic receptor internalization and down-regulationQ37672569
Molecular Mechanisms in the Receptor Action of BenzodiazepinesQ39255212
Receptors for the Age of Anxiety: Pharmacology of the BenzodiazepinesQ40081698
Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition.Q40912848
Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors.Q40946111
Activators of protein kinase C increase the phosphorylation of the synapsins at sites phosphorylated by cAMP‐dependent and Ca2+/calmodulin‐dependent protein kinases in the rat hippocampal sliceQ41082776
Bi-directional changes in the levels of messenger RNAs encoding gamma-aminobutyric acidA receptor alpha subunits after flurazepam treatmentQ41085954
Modulation of GABAA receptors by tyrosine phosphorylationQ41293490
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1100-1108
P577publication date2001-12-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleChronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms
P478volume79

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