EGF receptor in neoplasia and metastasis

scientific article

EGF receptor in neoplasia and metastasis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1008256842
P356DOI10.1007/BF00665957
P698PubMed publication ID8281612

P2093author name stringV Schirrmacher
R B Lichtner
K Khazaie
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Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor familyQ24314750
Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferationQ24558686
Signal transduction by receptors with tyrosine kinase activityQ27860624
Integrins: versatility, modulation, and signaling in cell adhesionQ27860844
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformationQ28187857
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinaseQ28208617
Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenesQ28213295
The c-erb-A protein is a high-affinity receptor for thyroid hormoneQ28282719
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous systemQ28292445
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substratesQ28624927
Oncogenes and signal transductionQ29547804
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectinQ30195270
The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*Q33188817
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Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factorQ33229227
Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancerQ69900051
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Elevated epidermal growth factor receptor binding in plutonium-induced lung tumors from dogsQ70125490
Evidence for autocrine/paracrine growth stimulation by transforming growth factor-alpha during the process of skin tumor promotionQ70126937
Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude miceQ70138628
Effects of epidermal growth factor receptor concentration on tumorigenicity of A431 cells in nude miceQ70143840
Altered expression of transforming growth factor-alpha in hereditary rat renal cell carcinomaQ70154015
Pyrimido-pyrimidine modulation of EGF growth-promoting activity and p21ras expression in rat mammary adenocarcinoma cellsQ70226875
Epidermal growth factor receptor in human breast cancer: correlation with steroid hormone receptors and axillary lymph node involvementQ70236129
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Biosynthesis of the epidermal growth factor receptor in human squamous cell carcinoma lines: secretion of the truncated receptor is not common to epidermal growth factor receptor-hyperproducing cellsQ70388828
Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cellsQ71275780
Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar culturesQ72911407
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The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouseQ76466792
Detection of epidermal growth factor receptors and E-cadherins in the basolateral membrane of A431 cells by laser scanning fluorescence microscopyQ33383911
A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.Q33580730
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A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2Q33938449
Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genesQ34162385
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude miceQ34169387
Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factorQ34181051
Autophosphorylation sites on the epidermal growth factor receptor.Q34245370
Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature proteinQ34370540
A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissueQ34592814
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actinQ34688924
Human epidermal growth factor: isolation and chemical and biological propertiesQ35075356
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The type 1 (EGFR-related) family of growth factor receptors and their ligandsQ35264192
Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancerQ35536048
Tumour invasion: effects of cell adhesion and motilityQ35633031
The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactionsQ35707924
Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasisQ35758968
Expression of growth factor receptors in human brain tumoursQ35982942
Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factorQ36204655
Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-betaQ36218283
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factorQ36219929
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation siteQ36230577
The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptorQ36231140
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC geneQ36232389
Cell adhesion in invasion and metastasisQ36289469
Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factorQ36443609
Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiographyQ36472123
Modulation of EGF receptor protooncogene expression by growth factors and hormones in human breast carcinoma cellsQ36506164
The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transductionQ36696910
Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell lineQ36741465
Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF: role for interreceptor interaction in kinase regulationQ36766355
Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell linesQ36779112
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-mycQ41614199
Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell lineQ41620522
Expression of the epidermal growth factor receptor in human small cell lung cancer cell linesQ41623159
Acquisition of a growth-inhibitory response to phorbol ester involves DNA damageQ41632760
Isolation of two distinct epithelial cell lines from a single feline mammary carcinoma with different tumorigenic potential in nude mice and expressing different levels of epidermal growth factor receptorsQ41673347
Effects of epidermal growth factor on growth response, morphology, and invasive potential of human endometrial carcinoma cell line RL95-2.Q41685551
Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptorQ41687505
Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cellsQ41688902
Modulation of phospholipase A2 activity by epidermal growth factor (EGF) in CHO cells transfected with human EGF receptor. Role of receptor cytoplasmic subdomainQ41691223
Effect of epidermal growth factor on the proliferation of human epithelial cancer cell lines: correlation with the level of occupied EGF receptorQ41691765
Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptorsQ41691854
Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patientQ41693276
Regulation of epidermal growth factor receptor expression in normal and transformed keratinocytesQ41706554
Expression of functional epidermal growth factor receptors in a human hematopoietic cell lineQ41706998
Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.Q41721460
Cellular distribution and biological activity of epidermal growth factor receptors in A431 cells are influenced by cell-cell contactQ41725636
Receptor-mediated processing of epidermal growth factor in the trophoblast of the human placentaQ41942936
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cellsQ42025518
Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancerQ42373194
Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylationQ42451299
Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformationQ42459659
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiationQ42466638
Expression of epidermal growth factor (EGF) and the EGF receptor in human tissuesQ42472227
Growth factor-independent proliferation of normal human neonatal keratinocytes: production of autocrine- and paracrine-acting mitogenic factorsQ42475636
Immunohistochemical localization of epidermal growth factor (EGF) and EGF receptor in human oral mucosa and its malignancyQ42476184
Regulation by epidermal growth factor of human squamous cell carcinoma plasminogen activator-mediated proteolysis of extracellular matrixQ42491388
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cellsQ42805935
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogeneQ42806006
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routingQ42806503
Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation siteQ42820005
Epidermal growth factor (EGF)-stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing EGF receptors truncated at residue 973Q42823976
Epidermal growth factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss 3T3 cells. Regulation through a protein kinase C-independent pathwayQ42827770
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cellsQ43107815
Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformationQ43183541
Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells.Q43405987
Characterization of hematopoietic cells transformed in vitro by AEV-H, a v-erbB-containing avian erythroblastosis virusQ43487656
Epidermal growth factor contents in seminal plasma as a marker of prostatic functionQ43489794
Bidirectional effects of Kupffer cells on hepatocyte proliferation in vitroQ43522437
Domains of laminin with growth-factor activityQ43523571
EGF-R as a hemopoietic growth factor receptor: the c-erbB product is present in chicken erythrocytic progenitors and controls their self-renewal.Q43629973
TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreasQ43826975
Evolving role of growth factors in the renal response to acute and chronic diseaseQ44052709
Signaling site of laminin with mitogenic activityQ44420031
EGF receptor expression in primary laryngeal cancer: correlation with clinico-pathological features and prognostic significanceQ44447552
Regulation of epidermal growth factor receptor gene expression in murine embryonal carcinoma cellsQ44678161
Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformationQ44691787
Epidermal growth factor stimulates the synthesis of cell-attachment proteins in the human breast cancer cell line PMC42.Q44893879
Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro.Q45083794
Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancerQ45141950
Transfer of functional EGF receptors to an IL3-dependent cell lineQ45149175
Retinoic acid alters epithelial differentiation during palatogenesisQ45149396
Insulin and insulin-like growth factor 1 stimulate proliferation of metastatic variants of colon carcinoma 26.Q45165343
EGF promotes in vivo tumorigenic growth of primary chicken embryo fibroblasts expressing v-myc and enhances in vitro transformation by the v-erbA oncogeneQ45586801
Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virusQ45800564
Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryosQ46790967
Rat prostatic growth factors: purification and characterization of high and low molecular weight epidermal growth factors from rat dorsolateral prostateQ47422540
Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitroQ48277157
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial originQ48536258
EGF receptor amplification and expression in human brain tumoursQ48565850
Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumorsQ36787477
A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.Q36807981
Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variantsQ36833392
Proviral-activated c-erbB is leukemogenic but not sarcomagenic: characterization of a replication-competent retrovirus containing the activated c-erbBQ36867653
Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB.Q36871987
Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cellsQ36903694
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptorQ37021857
The role of E-cadherin and scatter factor in tumor invasion and cell motilityQ37106879
Adhesion systems in embryonic epithelial-to-mesenchyme transformations and in cancer invasion and metastasisQ37106902
Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiationQ37356756
Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesisQ37364898
Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinasesQ37397390
Epidermal growth factor and the nervous systemQ37400150
Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrinsQ37597345
Transforming growth factor alpha contributes to the mechanism by which hypothalamic injury induces precocious pubertyQ37613536
The molecular biology of breast cancerQ37699385
Regulation of cell movement: the motogenic cytokinesQ37699401
Potential physiologic roles for epidermal growth factor in the kidneyQ37738853
The epidermal growth factor. A review of structural and functional relationships in the normal organism and in cancer cellsQ37949920
Growth factors in the regulation of pericellular proteolysis: a reviewQ38201615
Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies.Q38392799
Transforming growth factors.Q39464877
Transforming growth factor alphaQ39517957
Cellular Oncogenes and Multistep CarcinogenesisQ40161805
Cell surface molecules and tumor metastasis. Regulation of metastatic phenotypic diversityQ40168074
'Seed and soil' revisited: mechanisms of site-specific metastasisQ40254809
Epidermal and nerve growth factors in mammalian developmentQ40302430
Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutantsQ40653709
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factorsQ40728994
The assembly of signalling complexes by receptor tyrosine kinasesQ40853794
The estrogen receptor cooperates with the TGF alpha receptor (c-erbB) in regulation of chicken erythroid progenitor self-renewal.Q40872213
Activation of cMGF expression is a critical step in avian myeloid leukemogenesis.Q41080337
A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transductionQ41091475
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sitesQ41092861
Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sitesQ41092869
Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.Q41092881
Benign prostatic hyperplasia and growth factors: mechanisms and hypothesesQ41093028
Growth regulation of human renal carcinoma cells: role of transforming growth factor alphaQ41122072
Epidermal growth factor and transforming growth factor alpha stimulate or inhibit proliferation of a human renal adenocarcinoma cell line depending on cell status: differentiation of the two pathways by G protein involvementQ41129096
Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesisQ41141534
Epidermal growth factor receptor in human breast cancer: correlation with cytosolic and nuclear ER receptors and with biological and histological tumor characteristicsQ41200348
Isolation and Metastatic Properties of Detachment Variants of 816 Melanoma Cells 2Q41409126
Epidermal growth factor receptors associated to cytoskeletal elements of epidermoid carcinoma (A431) cellsQ41484044
Genes and membrane signals involved in neoplastic transformationQ41506362
Rapid effects of EGF on cytoskeletal structures and adhesive properties of highly metastatic rat mammary adenocarcinoma cellsQ41581592
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversionQ41589126
Proliferation of human colon cancer cells: role of epidermal growth factor and transforming growth factor alphaQ41590300
Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous systemQ49104371
Cell polarity and epithelial oncogenesis.Q52552950
Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cellsQ53437421
Incidence of precancerous foci of mammary glands and growth rate of transplantable mammary cancers in sialoadenectomized mice.Q53512517
Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.Q53531416
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.Q53554133
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanismsQ56911539
Isolation and structure of urogastrone and its relationship to epidermal growth factorQ59073848
Significance of epidermal growth factor receptor in advanced ovarian cancerQ60768653
Autocrine and paracrine growth regulation of human breast cancerQ61625136
Immunocytochemistry and in situ hybridisation of epidermal growth factor receptor and relation to prognostic factors in breast cancerQ67491834
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breastQ67660860
Heterogenous expression of the EGF-receptor in human breast carcinomaQ67845158
Lung-derived growth factor that stimulates the growth of lung-metastasizing tumor cells: identification as transferrinQ67858994
Blastocoel expansion in the preimplantation mouse embryo: stimulatory effect of TGF-alpha and EGFQ67895073
Epidermal growth factor receptor expression as a prognostic indicator in breast cancerQ67902986
Epidermal growth factor receptor-negative tumors are predominantly confined to the subgroup of estradiol receptor-positive human primary breast cancersQ67946416
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cellsQ68090789
Induction of transforming growth factor-alpha in activated human alveolar macrophagesQ68092790
Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-betaQ68093808
Liver epithelial cell migration induced by epidermal growth factor or transforming growth factor alpha is associated with changes in the gene expression of secreted proteinsQ68127085
Characterization of the epidermal growth factor receptor in preimplantation pig conceptusesQ68147225
Transforming growth factor beta 1 inhibits epidermal growth factor receptor endocytosis and down-regulation in cultured fetal rat hepatocytesQ68244964
Tumor invasion and extracellular matrix degradative enzymes: regulation of activity by organ factorsQ68255967
The response to epidermal growth factor of human maxillary tumor cells in terms of tumor growth, invasion and expression of proteinase inhibitorsQ68260872
Epidermal growth factor receptor in human breast cancers: Correlation with estrogen and progesterone receptorsQ68463883
Estimation of epidermal growth factor receptor in 177 breast cancers: correlation with prognostic factorsQ68491109
Epidermal growth factorQ68508116
Simultaneous estimation of epidermal growth factor receptors and steroid receptors in a series of 136 resectable primary breast tumorsQ68513875
Substrate-dependent effect of epidermal growth factor on intercellular adhesion and synthesis of triton-insoluble proteins in human carcinoma A431 cellsQ68794059
Differential effects of epidermal growth factor (EGF) on cell locomotion and cell proliferation in a cloned human embryonal carcinoma-derived cell line in vitroQ68829391
Reciprocal effects of epidermal growth factor and transforming growth factor beta on the anchorage-dependent and -independent growth of A431 epidermoid carcinoma cellsQ68832741
The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transductionQ69052663
Examination of the effects of epidermal growth factor on the production of urokinase and the expression of the plasminogen activator receptor in a human colon cancer cell lineQ69339934
Prognostic value of epidermal growth factor receptor in node-positive breast cancerQ69562515
Ligand-induced association of epidermal growth factor receptor to the cytoskeleton of A431 cellsQ69613282
Characterization of the epidermal growth factor receptor associated with cytoskeletons of A431 cellsQ69652465
Promotion of micrometastasis proliferation in a rat rhabdomyosarcoma model by epidermal growth factorQ69737766
Stimulation by EGF of the growth of EGF receptor-hyperproducing tumor cells in athymic miceQ69811861
Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumoursQ69856767
Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cellsQ69873417
P433issue3-4
P304page(s)255-274
P577publication date1993-09-01
P1433published inCancer and Metastasis ReviewsQ2647982
P1476titleEGF receptor in neoplasia and metastasis
P478volume12

Reverse relations

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