Why positive selection?

scientific article

Why positive selection? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1600-065X.1993.TB00645.X
P698PubMed publication ID8282319

P50authorPolly MatzingerQ3395388
P2860cites workApproaching the asymptote? Evolution and revolution in immunologyQ28274344
Sequence analysis of peptides bound to MHC class II moleculesQ28303686
Mice lacking MHC class II moleculesQ28588991
In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 typeQ34321361
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.Q34350288
Activation events during thymic selectionQ36231057
A fail-safe mechanism for maintaining self-toleranceQ36231679
CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.Q36231917
Is self tolerance H-2 restricted?Q72078236
A one-receptor view of T-cell behaviourQ72639690
Evidence from in vitro studies that tolerance to self antigens is MHC-restrictedQ72813262
High determinant density may explain the phenomenon of alloreactivityQ85697732
Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytesQ36269318
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?Q36340069
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigensQ36342063
Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cellsQ36347133
Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigensQ36348228
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineagesQ36353463
In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.Q36353659
Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cellsQ36355129
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathwaysQ36356927
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigensQ36357663
Thymus epithelium induces tissue-specific toleranceQ36361553
MHC restriction, alloreactivity, and thymic education: a common link?Q38219862
Selective induction of T-cell subsets by antibodies to the T-cell antigen receptor and to the subset-specific differentiation antigens CD8 and CD4.Q39486438
Cross-linking of CD4 and CD8 with the T-cell receptor complex: quaternary complex formation and T-cell repertoire selectionQ39579771
A speculative view of the multicomponent nature of T cell antigen recognitionQ39589017
Patterns of virus-immune T-cell responsiveness. Comparison of (H-2(k) x H-2(b)) {arrow} H-2(b) Radiation Chimeras and negatively selected H-2(b) lymphocytesQ39694872
Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?Q40643054
Influence of the major histocompatibility complex on lymphocyte interactions in antibody formationQ40680962
T-cell inhibition of humoral responsiveness. II. Theory on the role of restrictive recognition in immune regulationQ40690063
Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complexQ40701083
Specificity of T-cell cones illustrates altered self hypothesisQ41612846
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I moleculeQ41623815
Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cellsQ41807593
Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogenyQ42141543
Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cellsQ42767921
Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutininQ42936502
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stageQ43960795
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stagesQ44151375
Does T-cell tolerance require a dedicated antigen-presenting cell?Q46491587
Unresponsiveness to a foreign antigen can be caused by self-toleranceQ46860879
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.Q52483263
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesQ55042699
T cell tolerance by clonal elimination in the thymusQ56922465
Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction.Q57275625
A critical role of λ5 protein in B cell developmentQ57339983
Can B cells turn on virgin T cells?Q59054988
Self tolerance is H–2-restrictedQ59058139
Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cellsQ59063152
Identification of self peptides bound to purified HLA-B27Q59068162
Developmental regulation of T-cell receptor gene expressionQ59070328
Deletion of self-reactive T cells before entry into the thymus medullaQ59071302
Participation of CD4 coreceptor molecules in T-cell repertoire selectionQ59096940
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatmentQ59097267
A beginner's guide to major histocompatibility complex functionQ64448665
Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytesQ67998263
Three-receptor, clonal expansion model for selection of self-recognition in the thymusQ72073261
P304page(s)81-117
P577publication date1993-10-01
P1433published inImmunological ReviewsQ15724582
P1476titleWhy positive selection?
P478volume135

Reverse relations

cites work (P2860)
Q41718895Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance
Q53969369CD6: expression during development, apoptosis and selection of human and mouse thymocytes.
Q38817700Dissecting the two models of TCR structure-function relationships.
Q34762312Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC
Q35930529Evidence for a single-niche model of positive selection
Q35080684Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC.
Q36380676How many thymocytes audition for selection?
Q34122409Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment
Q48447599Immunology (1955-1975): the natural selection theory, the two signal hypothesis and positive repertoire selection
Q35850625On 'reactivity' versus 'tolerance'.
Q36415831On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells
Q37101244Purified hematopoietic stem cell allografts reconstitute immunity superior to bone marrow
Q35621984Regulatory T cells for tolerance therapy: revisiting the concept
Q33930698Restricted and conserved T-cell repertoires involved in allorecognition of class II major histocompatibility complex.
Q38952548Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire
Q81420783The multigenic structure of the MHC locus contributes to positive selection efficiency: a role for MHC class II gene-specific restriction
Q40895891The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules
Q36376819The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex
Q35077151Tritope model of restrictive recognition by the TCR.
Q34792441Uncertainties - discrepancies in immunology
Q34023421What is missing in immunology to understand immunity?
Q73200543[Autoimmunity: a concept to be revisited?]

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