The p53 tumor suppressor gene frequently is altered in gynecologic cancers

scientific article published on January 1994

The p53 tumor suppressor gene frequently is altered in gynecologic cancers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9378(94)70414-7
P698PubMed publication ID8296829

P50authorAndrew BerchuckQ114258102
Robert C. BastQ37841724
P2093author name stringMarks JR
Boyd J
Kohler MF
Wiseman R
P2860cites workSpectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancerQ72902089
Mutations in the p53 gene occur in diverse human tumour typesQ28249770
Genetic alterations during colorectal-tumor developmentQ28281200
p53 mutations in human cancersQ28302973
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Q29547773
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reactionQ29618515
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
The p53 proto-oncogene can act as a suppressor of transformationQ34440370
TP53 tumor suppressor gene: a model for investigating human mutagenesisQ35323631
p53 gene mutations and protein accumulation in human ovarian cancerQ36328863
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-lifeQ36782441
Wild-type p53 is a cell cycle checkpoint determinant following irradiationQ37152060
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell linesQ37537138
The p53 tumour suppressor geneQ37751892
Too many rodent carcinogens: mitogenesis increases mutagenesisQ37848515
Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast CancersQ38487557
Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivationQ41100590
p53 gene mutations in human endometrial carcinomaQ41108058
Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumoursQ41624924
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndromeQ41816411
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.Q43918911
Expression of p53 protein in colorectal cancer and its relationship to short-term prognosisQ44449506
Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage diseaseQ44617061
Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasiasQ53478411
High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas.Q54740689
High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidyQ55352522
Increased expression of mutant forms of p53 oncogene in primary lung cancerQ58212568
Mutagen testQ59008997
Human p53 gene localized to short arm of chromosome 17Q59074679
p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistryQ63446378
Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer GroupQ67979093
Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNAQ68087656
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasmsQ68097060
P433issue1 Pt 1
P407language of work or nameEnglishQ1860
P304page(s)246-252
P577publication date1994-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inAmerican Journal of Obstetrics and GynecologyQ4744256
P1476titleThe p53 tumor suppressor gene frequently is altered in gynecologic cancers
P478volume170

Reverse relations

cites work (P2860)
Q41035935A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas
Q33608825Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations
Q33431553Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity
Q40172885An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.
Q38067747Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis
Q38184472Association of p53 codon 72 polymorphism with prostate cancer: an update meta-analysis
Q30437752Associations between p53 overexpression and multiple measures of clinical outcome in high-risk, early stage or suboptimally-resected, advanced stage epithelial ovarian cancers A Gynecologic Oncology Group study
Q74099804Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: Comparative molecular analysis of epithelial and mesenchymal components
Q43479718Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma
Q28073246Chemoresistance and targeted therapies in ovarian and endometrial cancers
Q35829935Chromosome 17 aneusomy detected by fluorescence in situ hybridization in vulvar squamous cell carcinomas and synchronous vulvar skin
Q45181400Clinicopathological features of ovarian carcinosarcomas: a single institution experience
Q71116149Comparison of benign and malignant endometrial lesions for their p53 state, using immunohistochemistry and temperature-gradient gel electrophoresis
Q59791850Defective Nuclear Lamina in Aneuploidy and Carcinogenesis
Q35221856Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background
Q37215983Endometrial carcinoma: immunohistochemically detected proliferation index is a prognosticator of long-term outcome
Q41090745Establishment and Characterization of Cell Lines Derived from Uterine Malignant Mixed Müllerian Tumor
Q41090749Establishment and Characterization of Human Ovarian Carcinoma Cell Lines
Q35152940Evaluating the association between p53 codon 72 Arg>pro polymorphism and risk of ovary cancer: a meta-analysis
Q33284756Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
Q40765172Expression of Cell-Cycle Mediators in Ovarian Cancer Cells after Transfection with p16INK4a, p21WAF1/Cip-1, and p53
Q49067935Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract
Q53664165Expression of cell cycle regulatory proteins in ovaries prophylactically removed from Jewish Ashkenazi BRCA1 and BRCA2 mutation carriers: correlation with histopathology
Q71102147Expression of cell regulatory proteins in ovarian borderline tumors
Q74008143Identification of p53 Mutations in Endometrial Adenocarcinoma by Polymerase Chain Reaction-Single-Strand Conformation Polymorphism
Q33901618Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature
Q86398003Immunologic markers of cancer progression and prognosis
Q35213250Immunologic principles and immunotherapeutic approaches in ovarian cancer
Q36806849Immunostaining of p53 protein in ovarian carcinoma: correlation with histopathological data and clinical outcome
Q62631293Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
Q36135278Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours
Q40866629Li-Fraumeni Syndrome and the Role of the p53 Tumor Suppressor Gene in Cancer Susceptibility
Q53394047Loss of Expression of the p16 Tumor Suppressor Gene Is More Frequent in Advanced Ovarian Cancers Lacking p53 Mutations
Q33489525Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia
Q54660552Loss of heterozygosity and transcriptome analyses of a 1.2 Mb candidate ovarian cancer tumor suppressor locus region at 17q25.1-q25.2.
Q38469677Loss of heterozygosity of BRCA1, TP53 and TCRD markers analysed in sporadic endometrial cancer
Q35694610MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.
Q38472762Malignant Mixed Müllerian Tumors of the Uterus: A Clinicopathologic, DNA Flow Cytometric, p53, and mdm-2 Analysis of 44 Cases
Q34035891Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins
Q53432462Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins
Q40989135Molecular basis of endometrial cancer
Q35065032Molecular pathogenesis and prognostic factors in endometrial carcinoma
Q38474312Molecular profile of advanced-stage transitional cell carcinoma of the ovary
Q24634248Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers
Q36201331Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis
Q35552356Ovarian cancer and high-risk women—implications for prevention, screening, and early detection
Q51976333P53-specific T cell responses in patients with malignant and benign ovarian tumors: implications for p53 based immunotherapy
Q35983656Pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesis
Q85447231Prognostic Significance of Cell Cycle- and Invasion-Related Molecular Markers and Genomic Instability in Primary Carcinoma of the Vagina
Q79150763Prognostic Significance of p53 Mutation and p53 Overexpression in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study
Q34086636Prognostic biomarkers in ovarian cancer
Q92444290Promising Terpenes as Natural Antagonists of Cancer: An In-Silico Approach
Q43605486Quantification of p53 in Epithelial Ovarian Cancer
Q73493307Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer
Q47369346Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression).
Q33940195Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
Q58795530Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
Q44827392Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: dNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors
Q37702059The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies
Q33622369The biology of ovarian cancer: new opportunities for translation
Q43545828The microsomal epoxide hydrolase Tyr113His polymorphism: association with risk of ovarian cancer.
Q37703901The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment
Q57306058The prohibitin 3′ untranslated region polymorphism is not associated with risk of ovarian cancer
Q35202999Treatment of ovarian cancer: new strategies
Q43546464Valproate, but not lamotrigine, induces ovarian morphological changes in Wistar rats
Q35180856Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
Q43446793p53 overexpression in advanced-stage endometrial adenocarcinoma
Q30883366p53, estrogen and progesterone receptors in diagnostic curettage for endometrial adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy

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