The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein

scientific article published on January 2005

The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.25.2.533-544.2005
P932PMC publication ID543425
P698PubMed publication ID15632056
P5875ResearchGate publication ID8099044

P50authorJames L. ManleyQ38362017
P2093author name stringScott Millhouse
P2860cites workFunctional association of U2 snRNP with the ATP-independent spliceosomal complex EQ22254390
Cloning and characterization of PSF, a novel pre-mRNA splicing factorQ24322621
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicingQ24336359
CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motifQ24522636
Sorting out the complexity of SR protein functionsQ24539813
Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTDQ24540125
RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genesQ24550573
Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoterQ24552532
Functional domains of the human splicing factor ASF/SF2Q24564249
A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionQ24594778
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificitiesQ24598907
Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTDQ24601077
mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domainQ24602633
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcriptionQ28116305
Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionQ28131686
Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferencesQ28208318
Stimulatory effect of splicing factors on transcriptional elongationQ28214807
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursorsQ28251112
Specific interactions between proteins implicated in splice site selection and regulated alternative splicingQ28257351
Specific commitment of different pre-mRNAs to splicing by single SR proteinsQ28262042
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
A nuclear matrix protein interacts with the phosphorylated C-terminal domain of RNA polymerase II.Q28509334
The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteinsQ28570708
Integrating mRNA processing with transcriptionQ28610124
Pre-mRNA splicing: awash in a sea of proteinsQ29547272
An extensive network of coupling among gene expression machinesQ29547273
DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeatsQ68074474
Phosphorylation causes a conformational change in the carboxyl-terminal domain of the mouse RNA polymerase II largest subunitQ68187252
Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNPQ72202030
Growth-related changes in phosphorylation of yeast RNA polymerase IIQ74192542
RNA polymerase II and the integration of nuclear eventsQ29614772
RNA polymerase II is an essential mRNA polyadenylation factorQ29614773
Reversible phosphorylation of the C-terminal domain of RNA polymerase IIQ29614790
SR proteins and splicing controlQ29619936
The structure and function of proteins involved in mammalian pre-mRNA splicingQ29620286
Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR ProteinsQ30040281
Splice site selection, rate of splicing, and alternative splicing on nascent transcriptsQ30461752
A CTD function linking transcription to splicingQ33368388
Protein composition of mammalian spliceosomes assembled in vitroQ33847099
Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzymeQ33858428
SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain.Q34092879
The spliceosome: the most complex macromolecular machine in the cell?Q34278742
p54(nrb) associates with the 5' splice site within large transcription/splicing complexes.Q34310192
Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gelsQ34362249
The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomesQ34620338
Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II.Q34626147
The mRNA assembly line: transcription and processing machines in the same factoryQ34688409
The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/Y6.U5]tri-snRNP particleQ34767752
The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sitesQ35171559
ATP can be dispensable for prespliceosome formation in yeastQ35185397
Phosphorylated RNA polymerase II stimulates pre-mRNA splicingQ35197241
Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNAQ36254517
Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domainsQ36382489
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complexQ36670430
A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrixQ37398137
Tails of RNA polymerase II.Q38003896
Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicingQ38499037
Split genes and RNA splicingQ40389967
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.Q40395456
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicingQ41679293
Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit.Q41695825
An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathwayQ44540184
Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cellsQ44744396
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.Q51075771
Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription.Q52544550
The role of exon sequences in splice site selection.Q52545848
Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain KinasesQ63362926
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)533-544
P577publication date2005-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein
P478volume25