| scholarly article | Q13442814 |
| P2093 | author name string | Weiss A | |
| Bolen JB | |||
| Sieh M | |||
| P2860 | cites work | Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells | Q24336537 |
| SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins | Q28131774 | ||
| The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck | Q28506433 | ||
| Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck | Q28511623 | ||
| Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines | Q28647261 | ||
| Oncogenes and signal transduction | Q29547804 | ||
| Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src | Q30195559 | ||
| Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src | Q30195875 | ||
| Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts | Q33580738 | ||
| Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor | Q33620349 | ||
| Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs | Q34149224 | ||
| Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation | Q34166097 | ||
| Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase | Q34297751 | ||
| Ligand-induced association between the T-cell antigen receptor and two glycoproteins | Q34304264 | ||
| A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate | Q34504342 | ||
| Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src | Q34580219 | ||
| Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck | Q36351974 | ||
| Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain | Q36710757 | ||
| CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli | Q36730988 | ||
| Structural differences between repressed and derepressed forms of p60c-src | Q36757700 | ||
| Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes | Q36762437 | ||
| Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck) | Q36782472 | ||
| Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation | Q36847174 | ||
| CD45. A prototype for transmembrane protein tyrosine phosphatases | Q37117286 | ||
| Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production | Q37424143 | ||
| Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system | Q37548959 | ||
| src-related protein tyrosine kinases | Q38377127 | ||
| Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. | Q41678661 | ||
| SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src | Q41713730 | ||
| The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation | Q41719029 | ||
| Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation | Q41720956 | ||
| Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. | Q42459281 | ||
| Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain | Q42808327 | ||
| Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). | Q44573952 | ||
| Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells | Q46508660 | ||
| Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two-dimensional proteolytic mapping | Q46922563 | ||
| A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. | Q48373044 | ||
| Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56 lck | Q59025223 | ||
| Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway | Q59068009 | ||
| Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck | Q67984296 | ||
| Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation | Q69355760 | ||
| Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor | Q70053370 | ||
| Characterization of a monoclonal antibody directed against the phosphotyrosine kinase p56lck, in human T cells | Q70140186 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 315-321 | |
| P577 | publication date | 1993-01-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck | |
| P478 | volume | 12 |
| Q45996867 | A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. |
| Q36553748 | A functional T-cell receptor signaling pathway is required for p95vav activity |
| Q39450030 | A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. |
| Q72296881 | Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T cells |
| Q43054137 | Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation |
| Q34341764 | Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394. |
| Q46113259 | An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity |
| Q37631168 | Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity |
| Q22254087 | Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling |
| Q47561660 | Autoimmunity checkpoints as therapeutic targets in B cell malignancies |
| Q36563863 | Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway |
| Q30194700 | Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides |
| Q42050305 | Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling |
| Q42474633 | Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation |
| Q41196750 | CD4-dependent and -independent association of protein tyrosine kinases to the T cell receptor/CD3 complex of CD4+ mouse T lymphocytes |
| Q41312490 | CD45 phosphatase in Jurkat cells is necessary for response to applied ELF magnetic fields |
| Q24312667 | CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion |
| Q34963679 | CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells |
| Q73878070 | Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms |
| Q24318630 | Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro |
| Q71930175 | Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the zeta chain of the TCR/CD3/zeta complex |
| Q24305363 | Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes |
| Q43812081 | Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. |
| Q36229486 | Distinct roles for Syk and ZAP-70 during early thymocyte development |
| Q22254040 | Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling |
| Q34522144 | Examining multiprotein signaling complexes from all angles |
| Q28510142 | Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development |
| Q42494379 | Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling |
| Q24306924 | Functional interaction between c-Src and its mitotic target, Sam 68 |
| Q33786556 | Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases |
| Q54186374 | Growth cone enrichment and cytoskeletal association of non-receptor tyrosine kinases. |
| Q52510516 | HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. |
| Q37580455 | Insights into the initiation of TCR signaling |
| Q34763949 | Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck |
| Q73466587 | Intra- and intermolecular interactions of the catalytic domains of human CD45 protein tyrosine phosphatase |
| Q36262070 | Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4. |
| Q40696081 | Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. |
| Q36847674 | Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes |
| Q30193351 | Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain |
| Q36562252 | Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity |
| Q73878049 | Normal macrophage functions, but impaired induction of gamma delta T cells, at the site of bacterial infection in CD45 exon 6-deficient mice |
| Q33565239 | Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents |
| Q33690511 | Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45 |
| Q24322293 | Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn |
| Q33720532 | Positive and negative regulation of Src-family membrane kinases by CD45. |
| Q24535649 | Positive and negative regulation of T-cell activation through kinases and phosphatases |
| Q71697699 | Protein tyrosine kinase activity in 350 T1/T2, N0/N1 breast cancer. Preliminary results |
| Q34295063 | Protein tyrosine phosphatases as potential therapeutic targets |
| Q38003542 | Protein tyrosine phosphatases in lymphocyte activation and autoimmunity |
| Q34381500 | Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases |
| Q35956830 | Regulation of T-cell receptor signalling by membrane microdomains |
| Q41361371 | Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1. |
| Q28300799 | Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase |
| Q30192995 | Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes. |
| Q35914963 | Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor. |
| Q35076694 | Role of protein tyrosine phosphatases in T cell activation. |
| Q32138733 | SC35 plays a role in T cell development and alternative splicing of CD45. |
| Q37166168 | Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development |
| Q28243344 | Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells |
| Q36399415 | T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization |
| Q52738758 | TCR Signaling: Mechanisms of Initiation and Propagation. |
| Q36740495 | Th1 and Th2 cells form morphologically distinct immunological synapses. |
| Q40402665 | The B cell antigen receptor complex: mechanisms and implications of tyrosine kinase activation |
| Q24300013 | The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity |
| Q40791602 | The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells. |
| Q26772026 | The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
| Q30194714 | The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site |
| Q35914986 | The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling |
| Q37635718 | The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation |
| Q36669879 | The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection. |
| Q41171784 | The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex. |
| Q42971603 | The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells |
| Q33664705 | The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story |
| Q41682334 | The role of CD45 and CD45-associated molecules in T cell activation |
| Q41610113 | The role of CD45 in signal transduction |
| Q72106044 | The src family of tyrosine protein kinases in hemopoietic signal transduction |
| Q34150876 | The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function |
| Q30193457 | The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes |
| Q40487537 | The when and how of Src regulation |
| Q24304981 | Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase |
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