Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product

scientific article

Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID413569
P698PubMed publication ID8344246

P2093author name stringG Hofhaus
G Attardi
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Sequence and organization of the human mitochondrial genomeQ27860659
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenaseQ28116926
Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON)Q28251741
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathyQ28292821
URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunitQ28304374
The same domain motif for ubiquinone reduction in mitochondrial or chloroplast NADH dehydrogenase and bacterial glucose dehydrogenaseQ28330008
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementationQ29614475
Electron microscopic analysis of the peripheral and membrane parts of mitochondrial NADH dehydrogenase (Complex I)Q33324286
Complex I binds several mitochondrial NAD-coupled dehydrogenases.Q34260498
The NADH:ubiquinone oxidoreductase (complex I) of respiratory chainsQ35620962
Diseases of the mitochondrial DNA.Q35671010
Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cellsQ36209398
In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondriaQ36689236
The respiratory-chain NADH dehydrogenase (complex I) of mitochondriaQ37714057
Purification and molecular and enzymic properties of mitochondrial NADH dehydrogenaseQ39246098
Identification of the dicyclohexylcarbodiimide-binding subunit of NADH-ubiquinone oxidoreductase (Complex I).Q46031854
Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone.Q52461227
Isolation of chloramphenicol-resistant variants from a human cell lineQ67503270
Assembly of NADH: ubiquinone reductase (complex I) in Neurospora mitochondria. Independent pathways of nuclear-encoded and mitochondrially encoded subunitsQ68420543
Antibodies against the COOH-terminal undecapeptide of subunit II, but not those against the NH2-terminal decapeptide, immunoprecipitate the whole human cytochrome c oxidase complexQ68955313
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmitochondrial DNAQ27075
P304page(s)3043-3048
P577publication date1993-08-01
P1433published inThe EMBO JournalQ1278554
P1476titleLack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product
P478volume12

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cites work (P2860)
Q77760892Alteration of dark respiration and reduction of phototrophic growth in a mitochondrial DNA deletion mutant of Chlamydomonas lacking cob, nd4, and the 3' end of nd5
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Q52584019Complex I impairment, respiratory compensations, and photosynthetic decrease in nuclear and mitochondrial male sterile mutants of Nicotiana sylvestris.
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Q40021624Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase
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Q39715625Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly
Q91672723Four novel mutations in the mitochondrial ND4 gene of complex I in patients with multiple sclerosis
Q40966574Functional molecular aspects of the NADH dehydrogenases of plant mitochondria
Q42965440Inactivation of genes encoding subunits of the peripheral and membrane arms of neurospora mitochondrial complex I and effects on enzyme assembly.
Q37222663Lack of complex I is associated with oncocytic thyroid tumours
Q34429410Mitochondrial genetic control of assembly and function of complex I in mammalian cells
Q36444688Mitochondrial respiratory complex I: structure, function and implication in human diseases
Q36252857Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells
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Q35581352Novel large-range mitochondrial DNA deletions and fatal multisystemic disorder with prominent hepatopathy
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Q35310865Structural contribution of C-terminal segments of NuoL (ND5) and NuoM (ND4) subunits of complex I from Escherichia coli
Q24299240Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin
Q48136460The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease
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Q28368398The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme
Q39450692Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria

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