Regulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells

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Regulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/J.1460-2075.1993.TB06069.X
P932PMC publication ID413674
P698PubMed publication ID8404859

P2093author name stringPolack A
Hörtnagel K
Feederle R
Klobeck G
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma.Q48394103
The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal regionQ49162171
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locusQ56838225
A nuclear DNA attachment element mediates elevated and position-independent gene activityQ59073618
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cellsQ59074575
A variant translocation places the λ immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphomaQ59093573
A physical map and analysis of the murine C kappa-RS region show the presence of a conserved elementQ68342289
Role of chromosome translocations in human neoplasiaQ68818574
Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphomaQ69457818
Normal expression of a rearranged and mutated c-myc oncogene after transfection into fibroblastsQ69552626
Transgenic miceQ70082646
The mechanism of inactivation of the normal c-myc gene locus in human Burkitt lymphoma cellsQ70390232
A positive role for histone acetylation in transcription factor access to nucleosomal DNAQ70535287
Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocationsQ70866890
Multiple nuclear factors interact with the immunoglobulin enhancer sequencesQ24296245
Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locusQ24531855
Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c-mycQ30791622
Two antisense promoters in the immunoglobulin mu-switch region drive expression of c-myc in the Burkitt's lymphoma cell line BL67.Q33224591
Chromosome translocations clustered 5' of the murine c-myc gene qualitatively affect promoter usage: implications for the site of normal c-myc regulationQ33931387
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-livesQ33932184
Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sitesQ34161702
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggsQ34253051
N segment insertion and region-directed somatic hypermutation in a kappa gene of a t(2;8) chromosomal translocationQ34686804
Complementation between two cell lines lacking kappa enhancer activity: implications for the developmental control of immunoglobulin transcriptionQ36000787
Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factorsQ36684975
Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoterQ36703451
Characterization of the human immunoglobulin kappa gene 3' enhancer: functional importance of three motifs that demonstrate B-cell-specific in vivo footprintsQ36705439
Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-mycQ36777587
Serum-inducible expression of transfected human c-myc genesQ36795479
PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activityQ36809426
A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virusQ36885800
Electric field-mediated DNA transfer: transient and stable gene expression in human and mouse lymphoid cellsQ36910136
Fine Mapping of an Immunoglobulin Gene ActivatorQ36945043
Activation of a translocated c-myc gene: role of structural alterations in the upstream regionQ37576047
Premature termination of transcription from the P1 promoter of the mouse c-myc geneQ37648162
Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein geneQ40062679
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expressionQ40419300
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cellsQ40497185
Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signalsQ40659481
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant regionQ40818245
Expression of normal and translocated c-myc alleles in Burkitt's lymphoma cells: evidence for different regulationQ40818267
A STUDY OF MALIGNANT TUMOURS IN NIGERIA BY SHORT-TERM TISSUE CULTUREQ41210330
Negative autoregulation of c-myc gene expression is inactivated in transformed cellsQ41233339
A human chromosome 8 region with abnormalities in B cell, HTLV-I+ T cell and c-myc amplified tumoursQ41344456
Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cellsQ41349782
Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivoQ41535694
Absence of a paused transcription complex from the c-myc P2 promoter of the translocation chromosome in Burkitt's lymphoma cells: implication for the c-myc P1/P2 promoter shift.Q41548686
Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrateQ41633978
The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shiftQ41657361
The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc allelesQ41750000
Immunoglobulin kappa gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cellsQ41758304
Immunoglobulin kappa gene enhancers synergistically activate gene expression but independently determine chromatin structureQ42456490
The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcriptionQ43814141
Immunoglobulin gene transcription is activated by downstream sequence elementsQ43904180
The block of elongation in c-myc exon 1 is abolished in Burkitt's lymphoma cell lines with variant translocationQ45019101
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphomaQ48390201
Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cellsQ48393003
A lymphocyte-specific enhancer in the mouse immunoglobulin kappa geneQ48393280
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locusQ48393487
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectBurkitt lymphomaQ1016605
P304page(s)3913-3920
P577publication date1993-10-01
P1433published inThe EMBO JournalQ1278554
P1476titleRegulatory elements in the immunoglobulin kappa locus induce c-myc activation and the promoter shift in Burkitt's lymphoma cells
P478volume12

Reverse relations

cites work (P2860)
Q33613910Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.
Q77340293Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma
Q36732304Evidence for long-range oncogene activation by hepadnavirus insertion
Q37342819In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development
Q34551859Involvement of Rad18 in somatic hypermutation
Q92669992JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells
Q34747399Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene.
Q38301775NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma
Q38436671Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2.
Q36527994Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
Q40022897Nucleosomal structures of c-myc promoters with transcriptionally engaged RNA polymerase II.
Q30855713Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements
Q77301724Sodium butyrate suppresses apoptosis in human Burkitt lymphomas and murine plasmacytomas bearing c-myc translocations
Q41244135TATA box and Sp1 sites mediate the activation of c-myc promoter P1 by immunoglobulin kappa enhancers.
Q39221506The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
Q37013896The c-myc promoter: still MysterY and challenge
Q41251712The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.
Q34405431Translocations involving c-myc and c-myc function
Q40395601Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity.
Q39780657c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma
Q37340989c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1.

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