scholarly article | Q13442814 |
P356 | DOI | 10.1002/(SICI)1097-0215(20000615)86:6<848::AID-IJC14>3.0.CO;2-B |
P698 | PubMed publication ID | 10842200 |
P50 | author | Iain A McNeish | Q55130375 |
P2093 | author name string | L S Young | |
V Mautner | |||
D J Kerr | |||
A Mountain | |||
C J Wrighton | |||
P F Searle | |||
N K Green | |||
M G Gilligan | |||
S J Weedon | |||
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Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system | Q36754315 | ||
Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy | Q37593042 | ||
Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954. | Q40954656 | ||
Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species | Q41661399 | ||
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). | Q42606499 | ||
The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite | Q42801806 | ||
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. | Q42819703 | ||
Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells | Q43853243 | ||
Gene directed enzyme prodrug therapy for cancer. | Q45868152 | ||
Selective cell ablation in transgenic mice expression E. coli nitroreductase | Q45881111 | ||
The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954. | Q45881144 | ||
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase | Q67973853 | ||
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells | Q67988398 | ||
CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells | Q69657848 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Escherichia coli | Q25419 |
Adenoviridae | Q193447 | ||
P304 | page(s) | 848-854 | |
P577 | publication date | 2000-06-01 | |
P1433 | published in | International Journal of Cancer | Q332492 |
P1476 | title | Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase | |
P478 | volume | 86 |