Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

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Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase. is …
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P356DOI10.1002/(SICI)1097-0215(20000615)86:6<848::AID-IJC14>3.0.CO;2-B
P698PubMed publication ID10842200

P50authorIain A McNeishQ55130375
P2093author name stringL S Young
V Mautner
D J Kerr
A Mountain
C J Wrighton
P F Searle
N K Green
M G Gilligan
S J Weedon
P2860cites workConstitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vectorQ35068584
Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection systemQ36754315
Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapyQ37593042
Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.Q40954656
Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking speciesQ41661399
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).Q42606499
The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metaboliteQ42801806
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.Q42819703
Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cellsQ43853243
Gene directed enzyme prodrug therapy for cancer.Q45868152
Selective cell ablation in transgenic mice expression E. coli nitroreductaseQ45881111
The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.Q45881144
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphoraseQ67973853
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cellsQ67988398
CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cellsQ69657848
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
AdenoviridaeQ193447
P304page(s)848-854
P577publication date2000-06-01
P1433published inInternational Journal of CancerQ332492
P1476titleSensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase
P478volume86