scholarly article | Q13442814 |
P50 | author | Christian Czech | Q55835139 |
P2093 | author name string | J Menager | |
J N Octave | |||
L Mercken | |||
R Essalmani | |||
B Tasiaux | |||
P2860 | cites work | Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 |
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The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes. | Q48368096 | ||
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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease | Q77314168 | ||
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42 | Q77926799 | ||
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
P304 | page(s) | 1525-1528 | |
P577 | publication date | 2000-01-01 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease | |
P478 | volume | 275 |
Q33765040 | Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol |
Q41822677 | Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs |
Q40583437 | Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. |
Q34777681 | Dementia epidemiology |
Q48448830 | Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. |
Q34106518 | Experimental gerontology in Belgium: from model organisms to age-related pathologies |
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Q35172682 | Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex |
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