The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

scientific article

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.275.3.1525
P698PubMed publication ID10636839
P5875ResearchGate publication ID12677319

P50authorChristian CzechQ55835139
P2093author name stringJ Menager
J N Octave
L Mercken
R Essalmani
B Tasiaux
P2860cites workBeta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseQ24317439
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domainQ28141707
Presenilin is required for activity and nuclear access of Notch in DrosophilaQ28141718
Skeletal and CNS defects in Presenilin-1-deficient miceQ28238795
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinQ28260479
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainQ28273268
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activityQ29616491
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathwayQ34289409
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease geneQ34296093
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.Q34372665
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.Q34438409
The Alzheimer family of diseases: many etiologies, one pathogenesis?Q36002160
Immunolocalization of Alzheimer ?-amyloid peptide precursor to cellular membranes in baculovirus expression systemQ41654548
Baculovirus-infected cells do not produce the amyloid peptide of Alzheimer's disease from its precursorQ42064090
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cellsQ44466998
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and GolgiQ48334621
The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.Q48368096
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assayQ48917972
Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Q52177867
Alzheimer's disease. In search of gamma-secretase.Q52569584
Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.Q53319930
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.Q53324159
Subcellular distribution and turnover of presenilins in transfected cellsQ74516868
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl proteaseQ77314168
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42Q77926799
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1525-1528
P577publication date2000-01-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease
P478volume275

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cites work (P2860)
Q33765040Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol
Q41822677Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
Q40583437Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Q34777681Dementia epidemiology
Q48448830Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.
Q34106518Experimental gerontology in Belgium: from model organisms to age-related pathologies
Q42049875Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells
Q48716041Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer's disease
Q35545259Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)
Q28256875Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
Q36109130Presenilin function and gamma-secretase activity
Q35172682Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex
Q34265143Presenilins as therapeutic targets for the treatment of Alzheimer's disease
Q42044384Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
Q34502746Structure and location of amyloid beta peptide chains and arrays in Alzheimer's disease: new findings require reevaluation of the amyloid hypothesis and of tests of the hypothesis
Q51506172Tartary buckwheat flavonoids protect hepatic cells against high glucose-induced oxidative stress and insulin resistance via MAPK signaling pathways.

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