Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways

scientific article published on 28 March 2016

Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/AJT.13805
P932PMC publication ID5007157
P698PubMed publication ID27017850

P2093author name stringA Cao
R Zhang
S Germana
L A Turka
M Y Fan
N A Zwang
W D Hastings
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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant miceQ28215433
Signaling by the phosphoinositide 3-kinase family in immune cellsQ28283677
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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
PI3Kγ kinase activity is required for optimal T-cell activation and differentiation.Q42180812
Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunityQ42413337
Peritoneal macrophage priming in cirrhosis is related to ERK phosphorylation and IL-6 secretionQ42476081
Role of MAP kinases and PI3K-Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patientsQ42519528
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cellsQ43241045
Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signalingQ46662931
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.Q46674143
ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitisQ48026306
The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.Q48692254
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.Q51981008
Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.Q52041208
MEK inhibition, alone or in combination with BRAF inhibition, affects multiple functions of isolated normal human lymphocytes and dendritic cells.Q54357319
Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer.Q54375657
Cyclic AMP suppresses TGF-β-mediated adaptive Tregs differentiation through inhibiting the activation of ERK and JNK.Q54407744
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.Q54483264
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cellsQ56901500
PI(3)Kγ has an important context-dependent role in neutrophil chemokinesisQ57006266
Regulatory T cells in kidney allograft infiltrates correlate with initial inflammation and graft functionQ82632541
Rapid assessment of in vitro expanded human regulatory T cell functionQ84586428
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceQ29622850
Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.Q30497351
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Q33889530
A Disquisition on Suppressor T CellsQ34051239
Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer IQ34273324
Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway.Q34458364
The MAPK pathway across different malignancies: a new perspectiveQ34459097
Phosphoinositide 3-kinase in immunological systemsQ34555099
A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.Q34634834
Multiple control of interleukin-8 gene expressionQ34648084
Constitutive activation of MEK1 promotes Treg cell instability in vivoQ34737755
Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cellsQ34927437
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stabilityQ34979483
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.Q34979730
Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cellsQ35005900
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformationQ35133782
X-linked lymphoreticular disease in the scurfy (sf) mutant mouseQ35831357
Essential role of PI3Kdelta and PI3Kgamma in thymocyte survivalQ35849523
Polar opposites: Erk direction of CD4 T cell subsetsQ36084223
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.Q36693820
MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent mannerQ36907824
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancerQ37025086
PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by ErkQ37133085
Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative responseQ37376774
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and FunctionQ38035848
T-cell energy metabolism as a controller of cell fate in transplantationQ38309276
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumorsQ38406496
Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinaseQ38893052
Combination treatment with perifosine and MEK-162 demonstrates synergism against lung cancer cells in vitro and in vivoQ38907955
JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancerQ39226686
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cellsQ39695617
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.Q39758257
Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation.Q40083199
PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP.Q40594170
Regulation of Raf-Akt Cross-talkQ40727585
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migrationQ40900789
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humansQ41367429
p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model systemQ41732350
Does the PI3K pathway promote or antagonize regulatory T cell development and function?Q41864874
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2624-2638
P577publication date2016-03-28
P1433published inAmerican Journal of TransplantationQ4744273
P1476titleSelective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways
P478volume16

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cites work (P2860)
Q89777371Emerging role of BCR signaling inhibitors in immunomodulation of chronic lymphocytic leukemia
Q48097984Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice.
Q92758418Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor
Q40213848PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target.
Q39441315Targeted Therapy and Immunosuppression in the Tumor Microenvironment
Q38942832Treg-Centric View of Immunosuppressive Drugs in Transplantation: A Balancing Act.

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