A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis

scientific article published on August 1998

A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.32.20317
P698PubMed publication ID9685382
P5875ResearchGate publication ID13600562

P2093author name stringWalker B
Stephens G
Moran N
Fitzgerald D
Reilly D
Harriott P
O'Luanaigh N
P2860cites workInhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160Q22251286
Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domainQ28116142
Platelet alpha-granulesQ28267795
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregationQ28609213
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptorsQ28645681
The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock proteinQ33290796
Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domainQ34437525
A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complexQ34541247
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.Q36232656
Integrin cytoplasmic domains mediate inside-out signal transductionQ36233869
Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cellsQ36529569
Protein tyrosine phosphorylation and the adhesive functions of plateletsQ37421952
Transmembrane signaling across the platelet integrin glycoprotein IIb-IIIaQ40664745
Novel functions for calreticulin: interaction with integrins and modulation of gene expression?Q40682067
Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrinQ41293056
Breaking the integrin hinge. A defined structural constraint regulates integrin signalingQ43482152
The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.Q45938073
The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.Q53990149
A deletion in the ?? subunit locks platelet integrin ??IIb??3 into a high affinity stateQ57716770
A human erythroleukemia cell line synthesizes a functionally active glycoprotein IIb-IIIa complex capable of binding fibrinogenQ61943935
Integrin α chain cytoplasmic tails regulate “antibody-redirected” cell adhesion, independently of ligand bindingQ61961312
Inhibition of endoproteolytic cleavage of cytomegalovirus (HCMV) glycoprotein B by palmitoyl-peptidyl-chloromethyl ketoneQ68481623
The cytoplasmic domain of alphaIIb beta3. A ternary complex of the integrin alpha and beta subunits and a divalent cationQ71069890
Effect of cytoplasmic domain mutations on the agonist-stimulated ligand binding activity of the platelet integrin alphaIIbbeta3Q71825191
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectplatelet aggregationQ14913634
P304page(s)20317-20322
P577publication date1998-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleA sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis
P478volume273

Reverse relations

cites work (P2860)
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Q50937947A palmitoyl-tailed sequential oligopeptide carrier for engineering immunogenic conjugates.
Q46268351A palmitoylated peptide, derived from the acidic carboxyl-terminal segment of the integrin alphaIIb cytoplasmic domain, inhibits platelet activation
Q44693035A palmitylated peptide derived from the glycoprotein Ib beta cytoplasmic tail inhibits platelet activation
Q27621430A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit
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Q28255745ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation
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