Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease

scientific article published on September 2015

Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/14756366.2015.1077330
P698PubMed publication ID26327246
P5875ResearchGate publication ID281542339

P50authorClaudiu T SupuranQ28211545
Igor Almeida RodriguesQ40311078
Alane Beatriz VermelhoQ59821891
P2093author name stringAlcino Palermo de Aguiar
Claudia Magalhães Calvet
Dayanne da Rocha de Menezes
Igor Rodrigues Almeida
Mirian Claudia de Souza Pereira
P2860cites workCysteine protease inhibitors cure an experimental Trypanosoma cruzi infectionQ24645720
Novel amidines and analogues as promising agents against intracellular parasites: a systematic reviewQ26825025
Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell deathQ28485411
Neglected parasitic infections in the United States: Chagas diseaseQ33588466
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infectionQ33876638
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.Q34228426
Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatidsQ34272471
American trypanosomiasis (Chagas disease).Q34277333
Economic crisis and increased immigrant mobility: new challenges in managing Chagas disease in EuropeQ34399329
Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas deseaseQ34780286
Antagonic activities of Trypanosoma cruzi metacaspases affect the balance between cell proliferation, death and differentiationQ36084477
Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease.Q36505372
Heart failure in South AmericaQ36928523
Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospectsQ37286061
Aspartic peptidases of human pathogenic trypanosomatids: perspectives and trends for chemotherapy.Q37334816
Reversible cysteine protease inhibitors show promise for a Chagas disease cureQ37544765
Cruzain : the path from target validation to the clinicQ37887591
Epidemiology of Chagas disease in Europe: many calculations, little knowledgeQ38132635
Carbonic anhydrase inhibitors drug designQ38154557
Chagas disease: the challenge of polyparasitism?Q38192158
Therapeutical approaches under investigation for treatment of Chagas diseaseQ38214136
Rational drug design paradigms: the odyssey for designing better drugs.Q38369435
Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.Q39050394
Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruziQ39902784
Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruziQ39945921
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.Q42215365
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strainsQ44520752
Effects of a marine serine protease inhibitor on viability and morphology of Trypanosoma cruzi, the agent of Chagas diseaseQ44722468
Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas DiseaseQ58863183
P433issue6
P921main subjectChagas diseaseQ649558
P1104number of pages10
P304page(s)964-973
P577publication date2015-09-01
P1433published inJournal of Enzyme Inhibition and Medicinal ChemistryQ15708877
P1476titleHydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease
P478volume31

Reverse relations

cites work (P2860)
Q64250608Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines
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Q92896515Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani
Q64989121Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.
Q52645009Carbonic Anhydrases and Metabolism.
Q49570857Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles.
Q47971588Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum
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Q48205296Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi
Q92636305Quantitative Structure-Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity