Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis

scientific article published on 26 August 2015

Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/EXD.12853
P698PubMed publication ID26307945
P5875ResearchGate publication ID281291390

P50authorRichard GalloQ7325855
Benjamin J. LuftQ51739994
Benoît JaulhacQ88241626
Nathalie BoulangerQ116793142
P2093author name stringQuentin Bernard
Teruaki Nakatsuji
Xiahoua Yang
P2860cites workSalp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilizationQ21559503
Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infectionQ24548272
Induction of an outer surface protein on Borrelia burgdorferi during tick feedingQ24564198
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injuryQ24600221
Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammalsQ24624698
Toll-like receptors in Borrelia burgdorferi-induced inflammationQ28252119
The Lyme disease agent exploits a tick protein to infect the mammalian hostQ28264022
TLR signalingQ28291637
Lyme borreliosisQ29013670
Tolerance, danger, and the extended familyQ29547532
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-betaQ30498311
Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticksQ31034851
Salivating for knowledge: potential pharmacological agents in tick salivaQ33319614
The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infectionQ33603072
Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal CompartmentsQ33705109
Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infectionQ33905194
Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunityQ34006908
Ultraviolet radiation damages self noncoding RNA and is detected by TLR3.Q34286687
mRNA is an endogenous ligand for Toll-like receptor 3.Q34290592
Effect of Borrelia burgdorferi OspC at the site of inoculation in mouse skin.Q34290663
Antialarmin effect of tick saliva during the transmission of Lyme diseaseQ34529578
Borrelia burgdorferi elicited-IL-10 suppresses the production of inflammatory mediators, phagocytosis, and expression of co-stimulatory receptors by murine macrophages and/or dendritic cellsQ35075892
Microbial symbiosis with the innate immune defense system of the skinQ35216133
Rapid clearance of Lyme disease spirochetes lacking OspC from skinQ35689460
Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammationQ35791607
Chemokines and Toll-like receptors in Lyme disease pathogenesisQ36067849
The role of Borrelia burgdorferi outer surface proteinsQ36179733
Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells.Q36416025
Epithelial antimicrobial defence of the skin and intestineQ36584725
Who is really in control of skin immunity under physiological circumstances - lymphocytes, dendritic cells or keratinocytes?Q36604434
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine inductionQ36710716
Keratinocyte-fibroblast interactions in wound healingQ36792546
The skin as interface in the transmission of arthropod-borne pathogensQ36816174
Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organellesQ36941221
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory eventsQ36946570
Tick salivary compounds: their role in modulation of host defences and pathogen transmissionQ37105032
Inhibition of neutrophil function by two tick salivary proteinsQ37204467
Ticks and tick-borne pathogens at the cutaneous interface: host defenses, tick countermeasures, and a suitable environment for pathogen establishmentQ37322741
cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infectionQ37874954
Sensing necrotic cellsQ37991598
Smuggling across the border: how arthropod-borne pathogens evade and exploit the host defense system of the skinQ38189511
Saliva of the tick Ixodes dammini inhibits neutrophil functionQ39396186
Enhanced production of macrophage inflammatory protein 2 (MIP-2) by in vitro and in vivo infections with encephalomyocarditis virus and modulation of myocarditis with an antibody against MIP-2.Q39601862
MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinaseQ40040720
Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytesQ40440060
TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.Q40559584
Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected miceQ40883190
Identification and characterization of microRNAs by deep-sequencing in Hyalomma anatolicum anatolicum (Acari: Ixodidae) ticksQ41542236
TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferiQ41844903
TLR2 and TLR4 expression in atopic dermatitis, contact dermatitis and psoriasisQ42456233
Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cellsQ43268950
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A StreptococcusQ43566314
Evasin-3-like anti-chemokine activity in salivary gland extracts of ixodid ticks during blood-feeding: a new target for tick control.Q44297629
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infectionQ44329057
Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cellsQ44467140
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiationQ46167434
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cellsQ47593334
Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis salivaQ47838459
Production of tumor necrosis factor alpha by Treponema pallidum, Borrelia burgdorferi s.l., and Leptospira interrogans in isolated rat Kupffer cellsQ47899369
Defensin is suppressed by tick salivary gland extract during the in vitro interaction of resident skin cells with Borrelia burgdorferi.Q51739942
Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.Q52597722
Activation of Toll-like receptors alters the microRNA expression profile of keratinocytesQ57947467
P433issue1
P921main subjectsalivaQ155925
Lyme diseaseQ201989
toll-like receptorQ408004
keratinocyteQ1473931
P304page(s)26-31
P577publication date2015-08-26
P1433published inExperimental DermatologyQ15749509
P1476titleIxodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis
P478volume25

Reverse relations

cites work (P2860)
Q92598688A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis
Q46276251Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period
Q53028996Characterization of the early local immune response to Ixodes ricinus tick bites in human skin.
Q39467732For Whom the Bell Tolls (and Nods): Spit-acular Saliva.
Q37080249Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease
Q99233118Temporal analysis of the bovine lymph node transcriptome during cattle tick (Rhipicephalus microplus) infestation
Q39424930The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission.
Q55456540Ticks and Tick-Borne Infections: Complex Ecology, Agents, and Host Interactions.

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