A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation

scientific article published on 22 June 2017

A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2017.06.022
P932PMC publication ID5514432
P698PubMed publication ID28666732

P50authorYing WangQ42409026
P2093author name stringYi-Huan Chen
Zhen-Ya Shen
Fei Hua
Guang-Liang Bian
Hao-Yue Huang
Wen-Xue Ye
Yun-Sheng Yu
P2860cites workVersican degradation and vascular diseaseQ24600539
Regulation of TGF-β Superfamily Signaling by SMAD Mono-UbiquitinationQ26830449
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4Q28207975
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2Q28236792
Aneurysm syndromes caused by mutations in the TGF-beta receptorQ28259654
An essential role of Bmp4 in the atrioventricular septation of the mouse heartQ28586261
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart AssociationQ30238784
TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndromeQ33662519
Myocardial smad4 is essential for cardiogenesis in mouse embryosQ34009514
Demonstration of all connective tissue elements in a single section; pentachrome stains.Q34237133
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4).Q34306976
SNPs in the TGF-β signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancerQ34532211
Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunctionQ34785796
Vascular smooth muscle cell Smad4 gene is important for mouse vascular development.Q36234363
Essential role of endothelial Smad4 in vascular remodeling and integrity.Q36315610
TGF-β signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAEQ36340416
ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissectionsQ36672030
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesisQ37103999
Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakiaQ37747321
Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cellsQ38326238
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic AneurysmQ38809449
Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine AxisQ38837709
Hyaluronate binding properties of versicanQ41117567
Prevalence of thoracic aortopathy in patients with juvenile Polyposis Syndrome-Hereditary Hemorrhagic Telangiectasia due to SMAD4.Q53522731
Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissectionsQ57635825
Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart developmentQ81297429
SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunctionQ83782759
P921main subjectthoracic aortic aneurysmQ3616648
P304page(s)197-205
P577publication date2017-06-22
P1433published inEBioMedicineQ24912341
P1476titleA Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation
P478volume21

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cites work (P2860)
Q60908132A functional variant of enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection
Q87939445A role for proteoglycans in vascular disease
Q51759140Genetic variants in mRNA untranslated regions.
Q90636496Novel Alternatively Spliced Variants of Smad4 Expressed in TGF-β-Induced EMT Regulating Proliferation and Migration of A549 Cells

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