Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C.

scientific article published on March 1998

Platelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.12.7038
P698PubMed publication ID9507012
P5875ResearchGate publication ID277550840

P50authorMindaugas ValiusQ30505131
P2093author name stringVan Lint J
Ni Y
Merlevede W
Vandenheede JR
P2860cites workGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitQ24292767
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivoQ24650917
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
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Signalling through the lipid products of phosphoinositide-3-OH kinaseQ28241516
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signalQ28297924
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphateQ28301966
The complexity of Raf-1 regulationQ28305850
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reactionQ28378871
A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvationQ28568433
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Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypesQ28609740
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
Signal transduction through lipid second messengersQ34395640
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domainQ35731354
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and developmentQ36074211
PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zetaQ36237368
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectivelyQ36658598
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitorsQ37549774
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.Q37710202
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.Q40020748
Receptor tyrosine kinases and their targetsQ40757554
Protein kinase D (PKD): a novel target for diacylglycerol and phorbol estersQ40933310
Structure and regulation of phospholipase D.Q41008168
Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase.Q41379386
Use of retroviral vectors for gene transfer and expressionQ41582824
Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblastsQ42827640
Bombesin, endothelin and platelet-derived growth factor induce rapid translocation of the myristoylated alanine-rich C-kinase substrate in Swiss 3T3 cellsQ42833160
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)7038-7043
P577publication date1998-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titlePlatelet-derived growth factor stimulates protein kinase D through the activation of phospholipase Cgamma and protein kinase C.
P478volume273